Converging clinical data suggest that peripheral inflammation is likely involved in the pathogenesis of neuropsychiatric symptoms associated with metabolic syndrome (MetS). However, question arises as to whether increased prevalence behavioral alterations MetS also central inflammation, i.e. cytokine activation, brain areas particularly controlling behavior. To answer this question, we measured a mouse model MetS, namely diabetic and obese db/db mice, their healthy db/+ littermates emotional...

The postnatal period is a critical time window during which inflammatory events have significant and enduring effects on the brain, as consequence, induce alterations of emotional behavior and/or cognition later in life. However, long-term effect neonatal inflammation adolescence, sensitive for development neurodevelopmental psychiatric disorders, has been little studied. In this study, we examined whether an early-life challenge could alter behaviors spatial memory at adolescence adulthood...

Background: Two different species of sage, Salvia officinalis and lavandulaefolia, have demonstrated activities in cognitive function during preclinical clinical studies related to impaired health situations or single administration. Different memory processes been described be significantly positively impacted. Objective: Our objective is explore the potential these Salvia, their additional activities, healthy situations, prolonged administration, on subsequent mechanisms action putative...

Neuroinflammation constitutes a normal part of the brain immune response orchestrated by microglial cells. However, sustained and uncontrolled production proinflammatory factors together with activation contribute to onset chronic low-grade inflammation, leading neuronal damage cognitive as well behavioral impairments. Hence, limiting inflammatory improving resolution inflammation could be particularly interest prevent these alterations. Dietary n-3 long chain polyunsaturated fatty acids...

Aging is characterized by a decline in social behavior and cognitive functions leading to decrease life quality. In previous study, we show that fish hydrolysate supplementation prevents age-related spatial short-term memory long-term anxiety-like improves the stress response aged mice. The aim of this study was determine effects enriched with EPA/DHA or not on ability interaction during aging biological mechanisms involved. We showed for first time improved performance preference novelty...

Rhodiola rosea L. (R. rosea) is an adaptogenic plant increasing body resistance to stress. Its efficacy has been evidenced mainly in chronic stress models, data concerning its effect acute and underlying mechanisms being scarce. The objective was investigate the of repeated doses a R. hydroethanolic root extract (HRE) on hypothalamic pituitary adrenal response murine model mild also involved. Stress measured Balb/c mice having received by gavage HRE (5 g/kg) or vehicle daily for 2 weeks...

First evidence started to demonstrate the anxiolytic effects of low molecular weight peptides extracted from natural products, such as fish hydrolysate, but their underlying mechanisms remain be elucidated. The objective this study was evaluate effect a chronic administration hydrolysate on stress reactivity and understand involved. Stress response (corticosterone secretion, expression stress-responsive genes) measured in Balb/c mice supplemented with (300 mg/kg body weight) or vehicle daily...

Dietary anthocyanins may slow cognitive decline, improve performance and exert neuroprotective effects against neurodegenerative disorders. However, the underlying mechanisms of their action are not fully understood. This study investigated 12-week anthocyanin-rich bilberry extract supplementation (0.02%) on global gene expression in hippocampus ApoE-/- mice to help understanding molecular anthocyanin effects. Gene analysis identified 1698 differently expressed genes, with 611 downregulated...

Brain aging is characterized by a chronic low-grade inflammation, which significantly impairs cognitive function. Microglial cells, the immunocompetent cells of brain, present different phenotype, switching from homeostatic signature (M0) to more reactive phenotype called "MGnD" (microglial neurodegenerative phenotype), leading high production pro-inflammatory cytokines. Furthermore, microglial can be activated age-induced gut dysbiosis through vagus nerve or modulation peripheral immune...

Over the past several decades, stress has dramatically increased in occidental societies. The use of natural resources, such as fish hydrolysates, may be an attractive strategy to improve management. Our previous study demonstrated anxiolytic effects hydrolysate supplementation mice exposed acute mild by limiting stress-induced corticosterone release and modulating expression a number stress-responsive genes. Here, we explore hippocampal protein modulation induced submitted stress, with aim...

<title>Abstract</title> Neuroinflammation is a critical protective mechanism in healthy humans but can become harmful if chronic and/or unregulated, leading to neuronal damage and cognitive alterations. Microglia, which regulate inflammation the brain, dysfunctional with age, producing proinflammatory cytokines contributing low-grade neuroinflammation. Oxylipins, are lipid mediators synthesized from fatty acids, play dual roles inflammation, promoting both initiation resolution. Limiting...

Aging represents a natural and unavoidable phenomenon in organisms. With the acceleration of population aging, investigations into aging have garnered widespread global interest. One most striking aspects human is decline brain function, intricately tied to onset neurodegenerative conditions. This study aimed assess impact fish hydrolysate, rich low-molecular-weight peptides n-3 LC-PUFAs, on cognitive inflammatory response, oxidative stress via AGE-RAGE axis mouse model accelerated aging....

Aging is associated to cognitive decline that can lead neurodegenerative diseases and constitutes one of the main social economic issues 21st century. The loss memory, orientation processing abilities with aging are involved in autonomy quality life elderly. Brain structures memory such as hippocampus, cortex striatum, particularly affected by molecular cellular damage during this period. Lipid metabolism neurofunctional alterations, including disturbances synaptic plasticity neurogenesis,...