A5076099632- Neurological disorders and treatments
- Neuroscience and Neuropharmacology Research
- Parkinson's Disease Mechanisms and Treatments
- Genetic Neurodegenerative Diseases
- Neural dynamics and brain function
- Neuroscience and Neural Engineering
- Neuroendocrine regulation and behavior
- Stress Responses and Cortisol
- Neurotransmitter Receptor Influence on Behavior
- Cannabis and Cannabinoid Research
- Child and Adolescent Psychosocial and Emotional Development
- Autophagy in Disease and Therapy
- Photoreceptor and optogenetics research
- Menstrual Health and Disorders
- Genetics and Neurodevelopmental Disorders
- Mitochondrial Function and Pathology
- Ubiquitin and proteasome pathways
- Olfactory and Sensory Function Studies
- Nerve injury and regeneration
- Memory and Neural Mechanisms
- Infant Health and Development
- Endoplasmic Reticulum Stress and Disease
- GABA and Rice Research
- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
Université de Bordeaux
2015-2025
Centre National de la Recherche Scientifique
2015-2025
Institut des Maladies Neurodégénératives
2014-2024
Canadian Nautical Research Society
2023
Centre National pour la Recherche Scientifique et Technique (CNRST)
2020
Northwestern University
2004-2012
In-Q-Tel
2012
University of Tennessee Health Science Center
2004
Galen University
2003
Victor (Japan)
2003
Studies in dopamine-depleted rats indicate that the external globus pallidus (GPe) contains two main types of GABAergic projection cell; so-called "prototypic" and "arkypallidal" neurons. Here, we used correlative anatomical electrophysiological approaches to determine whether how this dichotomous organization applies dopamine-intact GPe. Prototypic neurons coexpressed transcription factors Nkx2-1 Lhx6, comprised approximately two-thirds all GPe neurons, were major cell type innervating...
The activity patterns of subthalamic nucleus (STN) neurons, which are intimately related to normal movement and abnormal in Parkinson's disease (PD), sculpted by feedback GABAergic inhibition from the reciprocally connected globus pallidus (GP). To understand principles underlying integration inputs, we used gramicidin-based patch-clamp recording STN neurons rat brain slices. Voltage-dependent Na + (Na v ) channels actively truncated synthetic IPSPs were required for autonomous activity. In...
The symptoms of Parkinson's disease (PD) are related to changes in the frequency and pattern activity reciprocally connected GABAergic external globus pallidus (GPe) glutamatergic subthalamic nucleus (STN). In idiopathic experimental PD, GPe STN exhibit hypoactivity hyperactivity, respectively, abnormal synchronous rhythmic burst firing. Following lesion midbrain dopamine neurons, emerges slowly intensifies gradually until it stabilizes after 2–3 weeks. Alterations cellular/network...
The basal ganglia (BG) inhibit movements through two independent circuits: the striatal neuron-indirect and subthalamic nucleus-hyperdirect pathways. These pathways exert opposite effects onto external globus pallidus (GPe) neurons, whose functional importance as a relay has changed drastically with discovery of distinct cell types, namely prototypic arkypallidal neurons. However, little is known about synaptic connectivity scheme different GPe neurons toward both motor-suppressing pathways,...
Abstract The direct modulation of subthalamic nucleus (STN) neurons by dopamine (DA) the substantia nigra (SN) is controversial owing to thick caliber and low density DA axons in STN. abnormal activity STN Parkinson's disease (PD), which central appearance symptoms, therefore thought result from loss striatum. We carried out three experiments rats explore function STN: (i) light electron microscopic analysis tyrosine hydroxylase (TH)‐, β‐hydroxylase (DβH)‐ DA‐immunoreactive structures...
The reciprocally connected GABAergic globus pallidus (GP)-glutamatergic subthalamic nucleus (STN) network is critical for voluntary movement and an important site of dysfunction in disorders such as Parkinson's disease. Although the GP a key determinant STN activity, correlated GP-STN activity rare under normal conditions. Here we define fundamental features connection that contribute to poorly activity. Juxtacellular labeling single neurons vivo stereological estimation total number...
The pattern of activity globus pallidus (GP) neurons is tightly regulated by GABAergic inhibition. In addition to extrinsic inputs from the striatum (STR-GP) other source GABA GP arises intrinsic intranuclear axon collaterals (GP-GP). While contribution striatal has been studied, notably its hyperactivity in Parkinson's disease (PD), properties and function inhibition remain poorly understood. Our objective was therefore test impact chronic dopamine depletion on pallido-pallidal...
Dopamine is a crucial factor in basal ganglia functioning. In current models of ganglia, dopamine postulated to act on striatal neurons. However, it may also the subthalamic nucleus (STN), key circuit. The data presented here were obtained brain slices using whole-cell patch clamp. They reveal that D5 receptors strengthen electrical activity subset neurons endowed with burst-firing capacity, resulting longer discharges spontaneous or evoked bursts. To distinguish between D1 and subtypes,...
Reciprocally connected glutamatergic subthalamic nucleus (STN) and GABAergic external globus pallidus (GP) neurons normally exhibit weakly correlated, irregular activity but following the depletion of dopamine in Parkinson's disease they express more highly rhythmic bursting activity. Patch clamp recording was used to test hypothesis that dopaminergic modulation reduces capability inputs pattern 'pathological' STN neurons. Electrically evoked GABA(A) receptor-mediated IPSCs exhibited...
The external globus pallidus (GP) is a key GABAergic hub in the basal ganglia (BG) circuitry, neuronal network involved motor control. In Parkinson's disease (PD), rate and pattern of activity GP neurons are profoundly altered contribute to symptoms disease. rodent models PD, striato-pallidal pathway hyperactive, extracellular GABA concentrations abnormally elevated GP, supporting hypothesis an alteration and/or glial clearance GABA. Here, we discovered existence persistent tonic inhibition...
Key points Reciprocally connected GABAergic external globus pallidus (GPe) and glutamatergic subthalamic nucleus (STN) neurons form a key network within the basal ganglia. In Parkinson's disease its models, abnormal rates patterns of GPe‐STN activity are linked to motor dysfunction. Using cell class‐specific optogenetic identification inhibition during cortical slow‐wave activation, we report that, in dopamine‐depleted mice, (1) D2 dopamine receptor expressing striatal projection (D2‐SPNs)...
Substance-induced social behavior deficits dramatically worsen the clinical outcome of substance use disorders; yet, underlying mechanisms remain poorly understood. Herein, we investigated role for corticotropin-releasing factor receptor 1 (CRF ) in acute sociability induced by morphine and related activity oxytocin (OXY)-and arginine-vasopressin (AVP)-expressing neurons paraventricular nucleus hypothalamus (PVN). For this purpose, used both CRF receptor-preferring antagonist compound...
Substance-induced social behavior deficits dramatically worsen the clinical outcome of substance use disorders; yet, underlying mechanisms remain poorly understood. Herein, we investigated role for corticotropin-releasing factor receptor 1 (CRF ) in acute sociability induced by morphine and related activity oxytocin (OXY)- arginine-vasopressin (AVP)-expressing neurons paraventricular nucleus hypothalamus (PVN). For this purpose, used both CRF receptor-preferring antagonist compound...
Defensive behaviors are essential for survival, with risk assessment enabling organisms to evaluate and respond potential threats. The dorsal raphe nucleus (DRN), a key neuromodulatory center, is crucial encoding motivational salience regulating arousal sleep-wake states through its diverse neuronal populations, including dopaminergic neurons (DRNDA). While the roles of DRNDA have been studied, their specific contributions threat evaluation less understood. Recent research identifies...