A5049021984- Stress Responses and Cortisol
- Neuroendocrine regulation and behavior
- Neurotransmitter Receptor Influence on Behavior
- Neuropeptides and Animal Physiology
- Tryptophan and brain disorders
- Receptor Mechanisms and Signaling
- Neuroscience and Neuropharmacology Research
- Hormonal Regulation and Hypertension
- Memory and Neural Mechanisms
- Adipose Tissue and Metabolism
- Regulation of Appetite and Obesity
- Menstrual Health and Disorders
- Child and Adolescent Psychosocial and Emotional Development
- Epilepsy research and treatment
- Retinal Development and Disorders
- Retinal Diseases and Treatments
- Amino Acid Enzymes and Metabolism
- Diet and metabolism studies
- Zebrafish Biomedical Research Applications
- Hematological disorders and diagnostics
- RNA Research and Splicing
- Psychopathy, Forensic Psychiatry, Sexual Offending
- Circadian rhythm and melatonin
- Retinoids in leukemia and cellular processes
- Pharmacological Receptor Mechanisms and Effects
Institut de Neurosciences Cognitives et Intégratives d’Aquitaine
2015-2025
Université de Bordeaux
2014-2025
Université Paris Cité
2024-2025
Inserm
2007-2025
Sorbonne Paris Cité
2024-2025
Centre National de la Recherche Scientifique
2013-2025
University of Padua
1996-2005
Scripps Research Institute
1998-2002
University of Catania
1997
The University of Queensland
1993
Corticotropin-releasing factor (CRF) and its family of peptides are critical coordinators homeostasis whose actions mediated through their receptors, CRF receptor 1 (CRFR1) CRFR2, found throughout the CNS periphery. The phenotypes mice deficient in either CRFR1 or CRFR2 demonstrate role these receptors play. CRFR1-mutant have an impaired stress response display decreased anxiety-like behavior, whereas CRFR2-mutant hypersensitive to increased behavior. To further elucidate roles both...
The negative affective symptoms of opiate withdrawal powerfully motivate drug-seeking behavior and may trigger relapse to heroin abuse. To date, no medications exist that effectively relieve the withdrawal. corticotropin-releasing factor (CRF) system has been hypothesized mediate motivational effects drug dependence. CRF signal is transmitted by two distinct receptors named receptor-1 (CRF 1 ) 2 . Here we report genetic disruption receptor pathways in mice eliminates states In particular,...
Substance-induced social behavior deficits dramatically worsen the clinical outcome of substance use disorders; yet, underlying mechanisms remain poorly understood. Herein, we investigated role for corticotropin-releasing factor receptor 1 (CRF ) in acute sociability induced by morphine and related activity oxytocin (OXY)-and arginine-vasopressin (AVP)-expressing neurons paraventricular nucleus hypothalamus (PVN). For this purpose, used both CRF receptor-preferring antagonist compound...
Substance-induced social behavior deficits dramatically worsen the clinical outcome of substance use disorders; yet, underlying mechanisms remain poorly understood. Herein, we investigated role for corticotropin-releasing factor receptor 1 (CRF ) in acute sociability induced by morphine and related activity oxytocin (OXY)- arginine-vasopressin (AVP)-expressing neurons paraventricular nucleus hypothalamus (PVN). For this purpose, used both CRF receptor-preferring antagonist compound...
ABSTRACT Corticotropin-releasing factor (CRF) systems are involved in locomotor and feeding behaviors. Two distinct CRF receptor subtypes, CRFR1 CRFR2, thought to mediate actions the central nervous system. However, role for each activity remains be determined. Using null mutant mice, present study examined functional significance of this ambulation feeding. treatment wild-type mice resulted increased levels locomotion whereas no change was observed CRFR1-deficient as compared...
The actions of corticotropin-releasing factor (CRF) and related peptides are mediated by two receptors (CRF(1) CRF(2)). respective role each subtype in the control food intake remains poorly known. In present study, we examined quantity microstructure ingestive behavior knockout (KO) mice lacking CRF(2) their wild-type (WT) littermates. Under basal conditions, KO showed increased nocturnal intake, evident as an zenith circadian cosinor analysis intake. Microstructure revealed that this...
Abstract Altered motivational processes might participate to the physiopathology of eating‐related disorders. The endogenous opioid system is thought mediate hedonic properties food intake. To assess role for µ‐opioid receptor (MOR) pathway in intake, present study we tested wild‐type and MOR‐deficient mice (MOR–/–) a nose‐poke operant paradigm chow or sucrose pellets. avoid confounding factors linked restriction/deprivation experience, were always provided with ad libitum . Although less...