A5057841370- Stress Responses and Cortisol
- Adipose Tissue and Metabolism
- Regulation of Appetite and Obesity
- Neuroinflammation and Neurodegeneration Mechanisms
- Birth, Development, and Health
- Diet and metabolism studies
- Neuropeptides and Animal Physiology
- Neonatal Respiratory Health Research
- Growth Hormone and Insulin-like Growth Factors
- Neuroendocrine regulation and behavior
- Estrogen and related hormone effects
- Pancreatic function and diabetes
- Anesthesia and Neurotoxicity Research
- Menopause: Health Impacts and Treatments
- Infant Nutrition and Health
- Nuclear Receptors and Signaling
- Hormonal Regulation and Hypertension
- Fibroblast Growth Factor Research
- Dietary Effects on Health
- Diabetes Treatment and Management
- Liver Disease Diagnosis and Treatment
- Neurogenesis and neuroplasticity mechanisms
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Diet, Metabolism, and Disease
- Biochemical Analysis and Sensing Techniques
Universidade de Vigo
2007-2023
Instituto Cajal
2007-2016
Consejo Superior de Investigaciones Científicas
2009-2012
Université de Bordeaux
2005-2007
Stress during fetal life increases the risk of affective and immune disorders later in life. The altered peripheral response caused by prenatal stress may impact on brain function modification local inflammation. In this study we have explored whether results alterations hippocampus female mice adult Pregnant C57BL/6 were subjected three times/day 45 minutes to restraint from gestational Day 12 delivery. Control non-stressed pregnant remained undisturbed. At four months age, prenatally...
After brain injury, astrocytes acquire a reactive phenotype characterized by series of morphological and molecular modifications, including the expression cytoskeletal protein vimentin. Previous studies have shown that estradiol down-regulates astrogliosis. In this study we assessed whether raloxifene tamoxifen, two selective estrogen receptor modulators, effects similar to in astrocytes. We also aging timing estrogenic therapy after ovariectomy influence action compounds. Four groups...
Using pharmacological tools, a role for opioid receptors in the regulation of food intake has been documented. However, involvement specific receptor subtypes remains questionable, and little information is available regarding energy metabolism. adult male mice lacking μ-opioid (MOR) gene (MOR−/−), we show that MOR not essential maintenance normal levels ad libitum but does modulate efficiency storage during high-fat diets through partitioning. When fed regular diet, MOR−/− displayed only...
It has been previously reported that the neuroprotective hormone oestradiol reduces microglia inflammatory activity. The objective of this study was to test whether two selective oestrogen receptor modulators, tamoxifen and raloxifene, modulate in vivo activation induced by peripheral administration lipopolysaccharide (LPS). Activation assessed white matter cerebellum using immunoreactivity for major histocompatability complex-II. Oestradiol, raloxifene decreased LPS male ovariectomized...
Human milk is the biological fluid with highest exosome amount and rich in microRNAs (miRNAs). These are key regulators of gene expression networks both normal physiologic disease contexts, miRNAs can influence many processes have also shown promise as biomarkers for disease. One aspects regeneration nervous system that there practically no molecules be used potential drugs. In first weeks lactation, we know human breast must contain mechanisms to transmit molecular information brain...
The actions of corticotropin-releasing factor (CRF) and related peptides are mediated by two receptors (CRF(1) CRF(2)). respective role each subtype in the control food intake remains poorly known. In present study, we examined quantity microstructure ingestive behavior knockout (KO) mice lacking CRF(2) their wild-type (WT) littermates. Under basal conditions, KO showed increased nocturnal intake, evident as an zenith circadian cosinor analysis intake. Microstructure revealed that this...
Abstract Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, and fatal lung disease. This disease characterized by an excessive accumulation of extracellular matrix deposition that modify normal physiology. Up to date, there are not efficient therapeutic tools fight IPF. Glucagon-like peptide-1 receptor (GLP-1R) activation plays essential role in functions pathological conditions. The aim the present study was possible beneficial effects administration GLP-1R agonist, liraglutide,...
Obesity has become one of the leading causes illness and mortality in developed world. Preclinical clinical data provide compelling evidence for ghrelin as a relevant regulator appetite, food intake, energy homeostasis. In addition, recently emerged major contributing factors to reward-driven feeding that can override state satiation. The corticotropin-releasing-factor system is also directly implicated regulation balance may participate pathophysiology obesity eating disorders. This paper...
In utero growth restriction and being born small for gestational age are risk factors respiratory morbidity. IUGR (in retardation) is associated to overall reduction in lung weight, surfactant content activity, impaired maturation of the alveolar type II cells, decreased formation. The renin-angiotensin system (RAS) may be a key target underlying pathophysiological alterations. GLP-1 agonists its receptor modulate expression levels different components RAS also very important production...
The glucagon-like peptide 1 is a pleiotropic hormone that has potent insulinotropic effects and key in treating metabolic diseases such as diabetes obesity. Glucagon-like exerts its by activating membrane receptor identified many tissues, including different brain regions. activates several signaling pathways related to neuroprotection, like the support of cell growth/survival, enhancement promotion synapse formation, autophagy, inhibition secretion proinflammatory cytokines, microglial...
Perinatal maternal malnutrition is related to altered growth of tissues and organs. The nervous system development very sensitive environmental insults, being the hippocampus a vulnerable structure, in which number neurons granular cells has been observed. Moreover, glial are also affected, increased expression proinflammatory mediators We studied effect Glucagon-like peptide-1 receptor (GLP-1R) agonists, liraglutide, have potent metabolic neuroprotective effects, order ameliorate/prevent...
The growth and development of the human brain is a long complex process that requires precise sequence genetic molecular events.
Subchronic gestational stress leads to permanent modifications in the hippocampus-hypothalamus-pituitary-adrenal axis of offspring probably due increase circulating glucocorticoids known affect prenatal programming. The aim this study was investigate whether cell turnover is affected hippocampus-hypothalamus-pituitary by subchronic and intracellular mechanisms involved. Restraint performed pregnant rats during last week gestation (45 minutes; 3 times/day). Only male were used for sacrificed...