A5022233474- Ion channel regulation and function
- Ion Channels and Receptors
- Pain Mechanisms and Treatments
- Chronic Disease Management Strategies
- Cardiac electrophysiology and arrhythmias
- Nicotinic Acetylcholine Receptors Study
- Neuroscience and Neuropharmacology Research
- Neurobiology and Insect Physiology Research
- Aging, Health, and Disability
- Neural dynamics and brain function
- Mobile Health and mHealth Applications
- Geriatric Care and Nursing Homes
- Regulation of Appetite and Obesity
- Neuroscience and Music Perception
- Cognitive and developmental aspects of mathematical skills
- EEG and Brain-Computer Interfaces
- Heart Rate Variability and Autonomic Control
- Medication Adherence and Compliance
- Functional Brain Connectivity Studies
- Psoriasis: Treatment and Pathogenesis
- Diabetes Treatment and Management
- Hormonal Regulation and Hypertension
- Nuclear Receptors and Signaling
- Neuroscience and Neural Engineering
- Erythrocyte Function and Pathophysiology
Valencian International University
2024-2025
Hospital del Mar Research Institute
2024
Municipal Institute for Medical Research
2024
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública
2024
Hospital Del Mar
2024
Universidade de Vigo
2018-2023
Hospital Nacional de Parapléjicos
2021-2023
Servicio de Salud de Castilla La Mancha
2021-2023
Cortical neuron-astrocyte communication in response to peripheral sensory stimulation occurs a topographic-, frequency-, and intensity-dependent manner. However, the contribution of this functional interaction processing inputs consequent behavior remains unclear. We investigate role astrocytes information at circuit behavioral levels by monitoring manipulating astrocytic activity vivo. show that control dynamic range cortical network activity, optimizing its responsiveness incoming inputs....
In the realm of Evidence-Based Medicine, introduced by Gordon Guyatt in early 1990s, integration machine learning technologies marks a significant advancement towards more objective, evidence-driven healthcare. Medicine principles focus on using best available scientific evidence for clinical decision-making, enhancing healthcare quality and consistency integrating this with clinician expertise patient values. Patient-Reported Outcome Measures (PROMs) Experience (PREMs) have become essential...
Background Patient-reported outcome and experience measures can play a critical role in providing patient-centered value-based health care to growing population of patients who are chronically ill. Value-based telemedicine platforms such as the Naveta initiative may facilitate effective integration these tools into systems. Objective This study aims evaluate response rate electronic patient-reported (ePROMs) (ePREMs) among participating its correlations with sociodemographic clinical...
Two-pore domain potassium channels (K2P) constitute major candidates for the regulation of background currents in mammalian cells. Channels TREK subfamily are also well positioned to play an important role sensory transduction due their sensitivity a large number physiological and physical stimuli (pH, mechanical, temperature). Following our previous report describing molecular expression different K2P vagal system, here we confirm that functionally expressed neurons from mouse nodose...
Bradykinin (BK), a hormone inducing pain and inflammation, is known to inhibit potassium M-currents (IM) increase the excitability of superior cervical ganglion (SCG) neurons by activating Ca2+-calmodulin pathway. M-current also reduced muscarinic agonists through depletion membrane phosphatidylinositol 4,5-biphosphate (PIP2). Similarly, activation receptors inhibits current two-pore domain channels (K2P) "Tandem pore-domains in Weakly Inward rectifying K+ channel (TWIK)-related channels"...
Objective: This study aimed to use the Person-Centered Coordinated Care Experience Questionnaire (P3CEQ) assess experience of person-centered coordinated care among people with long-term conditions in Balearic Islands, Spain. Methods: Over 1300 participants receiving treatment for chronic or HIV pre-exposure prophylaxis were invited complete P3CEQ and a socio-demographic questionnaire, both administered electronically via Naveta app. The assesses key domains P3C through an 11-item...
Background and purpose Psoriasis is a chronic, immune-mediated inflammatory skin disease that significantly impacts patients’ quality of life. The integration telepharmacy has the potential to enhance patient care by providing flexible personalized pharmaceutical follow-up. This study (TELEPROM Psoriasis) evaluates model for evaluating electronic Patient-Reported outcomes (ePROMs) individuals with moderate severe plaque psoriasis in Spain biological treatment. Experimental approach...
The ionic mechanisms controlling the resting membrane potential (RMP) in superior cervical ganglion (SCG) neurons have been widely studied and M-current (IM, KCNQ) is one of key players. Recently, with discovery presence functional TREK-2 (TWIK-related K+ channel 2) channels SCG neurons, another main contributor for setting value has appeared. In present work, we quantified contribution to at physiological temperature its role excitability using patch-clamp techniques. process discovered...
Focal application of transcranial static magnetic field stimulation (tSMS) is a neuromodulation technique, with predominantly inhibitory effects when applied to the motor, somatosensory or visual cortex. Whether this approach can also transiently interact dorsolateral prefrontal cortex (DLPFC) function remains unclear. The suppression habitual competitive responses one core executive functions linked DLPFC function. This study aimed assess impact tSMS on contributions control and response...
Background and Purpose: Verapamil, a drug widely used in certain cardiac pathologies, exert its therapeutic effect mainly through the blockade of L-type calcium channels. However, we also know that both voltage-dependent potassium channels are blocked by verapamil. Because sympathetic neurons superior cervical ganglion (SCG) known to express good variety currents, finely tune activity, speculated verapamil on these SCG could explain part action this drug. To address question, decided study,...
<sec> <title>BACKGROUND</title> Patient-reported outcome and experience measures can play a critical role in providing patient-centered value-based health care to growing population of patients who are chronically ill. Value-based telemedicine platforms such as the Naveta initiative may facilitate effective integration these tools into systems. </sec> <title>OBJECTIVE</title> This study aims evaluate response rate electronic patient-reported (ePROMs) (ePREMs) among participating its...
Background and Purpose: Verapamil, a drug widely used in certain cardiac pathologies, exert its therapeutic effect mainly through the blockade of L-type calcium channels. However, we also know that both voltage-dependent potassium channels are blocked by verapamil. Because sympathetic neurons superior cervical ganglion (SCG) known to express good variety currents, finely tune activity, speculated verapamil on these SCG could explain part action this drug. To address question, decided study,...
Cortical astrocytes respond to peripheral sensory stimulation in a topographic-, frequency- and intensity-dependent manner. However, whether astrocytic activity contributes the processing of information consequent behavior remains unclear. We have investigated role at circuit behavioral levels by monitoring manipulating vivo. show that control dynamic range cortical network activity, optimizing its responsiveness incoming inputs. The astrocytic-modulation set threshold for tactile thermal...