A5071646456- Transcranial Magnetic Stimulation Studies
- Neural dynamics and brain function
- Functional Brain Connectivity Studies
- Spinal Cord Injury Research
- Cerebral Palsy and Movement Disorders
- Neural and Behavioral Psychology Studies
- Stroke Rehabilitation and Recovery
- Pain Mechanisms and Treatments
- Pain Management and Treatment
- Muscle activation and electromyography studies
- Visual perception and processing mechanisms
- EEG and Brain-Computer Interfaces
- Memory and Neural Mechanisms
- Multiple Sclerosis Research Studies
- Photoreceptor and optogenetics research
- Migraine and Headache Studies
- Heart Rate Variability and Autonomic Control
- Vestibular and auditory disorders
- Obsessive-Compulsive Spectrum Disorders
- Nerve injury and regeneration
- S100 Proteins and Annexins
- Injury Epidemiology and Prevention
- Stock Market Forecasting Methods
- Evacuation and Crowd Dynamics
- Balance, Gait, and Falls Prevention
Servicio de Salud de Castilla La Mancha
2011-2024
Hospital Nacional de Parapléjicos
2011-2024
We are constantly interacting with our environment whilst we encode memories. However, how actions influence memory formation remains poorly understood. Goal-directed movement engages the locus coeruleus (LC), main source of noradrenaline in brain. Noradrenaline is also known to enhance episodic encoding, suggesting that action could improve via LC engagement. Here demonstrate, across seven experiments, (Go-response) enhances encoding for stimuli unrelated itself, compared inhibition (NoGo)....
Transcranial static magnetic field stimulation (tSMS) was recently introduced as a promising tool to modulate human cerebral excitability in noninvasive and portable way. However, demonstration that fields can influence brain activity behavior is currently lacking, despite evidence interfere with neuronal function animals. Here we show transcranial application of (120–200 mT at 2–3 cm from the magnet surface) over occiput produces focal increase power alpha oscillations underlying cortex....
The role of neuronal oscillations in human somatosensory perception is currently unclear. To address this, here we use noninvasive brain stimulation to artificially modulate cortical network dynamics the context neurophysiological and behavioral recordings. We demonstrate that transcranial static magnetic field (tSMS) over parietal cortex increases oscillatory power specifically alpha range, without significantly affecting bottom-up thalamocortical inputs indexed by early component evoked...
Background Transcranial static magnetic field stimulation (tSMS) reduces cortical excitability in humans. Methods The objective of this study was to determine whether tSMS over the occipital cortex is effective reducing experimental photophobia. In a sham-controlled double-blind crossover study, (or sham) applied for 10 minutes with cylindrical magnet on occiput 20 healthy subjects. We assessed subjective discomfort induced by low-intensity and high-intensity visual stimuli presented dark...
Background: Multiple sclerosis (MS) is an autoimmune disorder of the CNS in which inflammation, demyelination and axonal damage central nervous system coexist. Fatigue one most disabling symptoms MS little known about neurophysiological mechanisms involved. Methods: To give more mechanistic insight fatigue MS, we studied a cohort 17 patients group 16 age-matched healthy controls. Baseline Severity Scales Rating were obtained from both groups to check level perform statistical correlations...
Static magnetic fields have been shown to induce effects on the human brain. Different experiments seem support idea that moderate static field can exert some influence gating processes of membrane channels. In this article we visit order magnitude energy terms associated with applied (between 10 and 200 milliteslas). It is gradients Zeeman inhomogeneous pressures 10-2 Pa. The surface tension generated by pressure, delimiting brain region subject relevant gradients, found range between 10-1...
Background Poststroke fatigue is a prevalent issue among stroke survivors, significantly impeding functional recovery and diminishing their quality of life. Aim This prospective cohort study aims to investigate the association between poststroke extent in survivors ischemic hemorrhagic strokes. Additionally, it seeks delineate temporal progression these two subtypes. Methods We assessed 79 patients recovering from acute or was quantified using Fatigue Severity Scale (FSS) Numeric Rating (NRS...
Abstract Transcranial direct current stimulation modifies cortical excitability and in consequence some cerebral functions. In the present study we aimed to elucidate whether tDCS could affect temperature pain perceptions healthy subjects testing different parameters. A total of 20 were studied by means quantitative sensory testing. Two experiments performed. First, effects 15 minutes 2 mA anodal transcranial applied over left M1 parietal cortex two separated sessions. Then, tested 5 a sham...
BackgroundObsessive-compulsive disorder (OCD) has consistently been linked to abnormal frontostriatal activity. The electrophysiological disruption in this circuit, however, remains be characterized.Objective/hypothesisThe primary goal of study was investigate the neuronal synchronization OCD patients. We predicted aberrant oscillatory activity frontal regions compared healthy control subjects, which would alleviated by deep brain stimulation (DBS) nucleus accumbens (NAc).MethodsWe scalp EEG...
Fatigue has a profound impact on patients with spinal cord injury (SCI), but only limited treatments are available. The aim of this study was to determine the prevalence fatigue in SCI and its association clinical demographic factors. We used an internet-based survey face-to-face interview estimate population. measured using Severity Scale (FSS). Clinically significant defined as FSS scores greater than or equal four. A total 253 participants were included study. present one third our...
Background. Transcranial direct current stimulation (tDCS) of the primary motor cortex (M1) has an analgesic effect superior to a placebo in chronic pain. Some years ago, tDCS was implemented at Hospital Nacional Paraplegics (Toledo, Spain) treat patients with pharmacological resistance Objective. The main objectives this study were (1) confirm safety one-year treatment; (2) estimate number after one year (3) describe effects on pain intensity during and (4) identify factors related...
Abstract Focal application of transcranial static magnetic field stimulation (tSMS) over the human motor cortex induces local changes in cortical excitability. Whether tSMS can also induce distant network effects, and how these effects may vary time, is currently unknown. In this study, we applied 10 min left healthy subjects using a real/sham parallel design. To measure at sensori-motor level, used resting-state fMRI. Real tSMS, but not sham, reduced functional connectivity within...
Focal application of transcranial static magnetic field stimulation (tSMS) is a neuromodulation technique, with predominantly inhibitory effects when applied to the motor, somatosensory or visual cortex. Whether this approach can also transiently interact dorsolateral prefrontal cortex (DLPFC) function remains unclear. The suppression habitual competitive responses one core executive functions linked DLPFC function. This study aimed assess impact tSMS on contributions control and response...
This study aimed: (1) to evaluate the hand motor fatigability in people with spinal cord injury (SCI) and compare it measurements obtained form an able-bodied population; (2) tetraplegia paraplegia; (3) analyse if is different SCI without clinical significant perceived fatigability.96 participants (40 cervical 56 thoracolumbar) 63 controls performed a simple isometric task assess fatigability. The Fatigue Severity Scale was used for evaluation.The main results of this can be summarized as...
Abstract In the last decade, fatigue in clinical populations has been re-conceptualized, including dimensions such as perceived (trait and state fatigue) fatigability. The aim of this study was to evaluate different expressions Spinal Cord Injury (SCI) Multiple Sclerosis (MS) participants compared able-bodied controls, during activities daily living, especially gait. A total 67 were included (23 with SCI, 23 MS, 21 controls). All performed two functional tests (6-Minute Walk Test 10-Meter...
Abstract Study design Double-blind, randomized, placebo-controlled, parallel-group multicentric phase IIA clinical trial. Objective To assess the safety and tolerability of oral administration NFX-88 in subjects with chronic spinal cord injury (SCI) explore its efficacy pain control. Setting A total 7 rehabilitation units Spain. Methods 61 adult traumatic complete or incomplete (C4-T12 level), were randomised 1:1:1:1 to a placebo, NFX88 1.05 g, 2.1 4.2 g/day for up 12 weeks. The placebo was...
Background/Hypothesis: Creativity is a cognitive process that affects the performance of many daily life activities. This process, in turn, influenced not only by various environmental factors but also numerous individual aspects. Chronic pain one has proven to negatively affect creativity. Our hypothesis people with migraine interictal phase have lower levels creativity than control group. Methods: We collected data from participants ( n = 31) and non-migraine group 30). used Alternative...