A5019545057- Lipid Membrane Structure and Behavior
- Receptor Mechanisms and Signaling
- Fatty Acid Research and Health
- Lipid metabolism and biosynthesis
- Cancer, Hypoxia, and Metabolism
- Neurotransmitter Receptor Influence on Behavior
- Sphingolipid Metabolism and Signaling
- Neuroscience and Neuropharmacology Research
- Cancer, Lipids, and Metabolism
- Metabolomics and Mass Spectrometry Studies
- Cholesterol and Lipid Metabolism
- Eicosanoids and Hypertension Pharmacology
- Metabolism and Genetic Disorders
- Protein Kinase Regulation and GTPase Signaling
- Endoplasmic Reticulum Stress and Disease
- Peroxisome Proliferator-Activated Receptors
- Autophagy in Disease and Therapy
- Drug Transport and Resistance Mechanisms
- Neuropeptides and Animal Physiology
- Pharmacological Receptor Mechanisms and Effects
- Cellular transport and secretion
- Alzheimer's disease research and treatments
- Mitochondrial Function and Pathology
- Mass Spectrometry Techniques and Applications
- Protein Structure and Dynamics
Universitat de les Illes Balears
2015-2024
Clinica Rotger
2024
Fundació Universitat-Empresa de les Illes Balears
2004-2024
Research Institute of Health Sciences
2006-2015
Cellular Biomedicine Group (United States)
2012
Zero to Three
2008
Instituto de la Grasa
2003-2007
Consejo Superior de Investigaciones Científicas
2003-2007
Health Research Institute of the Balearic Islands
2007
Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol
2007
Numerous studies have shown that high olive oil intake reduces blood pressure (BP). These positive effects of frequently been ascribed to its minor components, such as α-tocopherol, polyphenols, and other phenolic compounds are not present in oils. However, this study we demonstrate the hypotensive effect is caused by oleic acid (OA) content (≈70–80%). We propose increases OA levels membranes, which regulates membrane lipid structure (H II phase propensity) a way control G protein-mediated...
The mechanism of action 2-hydroxyoleic acid (2OHOA), a potent antitumor compound, has not yet been fully elucidated. Here, we show that human cancer cells have markedly lower levels sphingomyelin (SM) than nontumor (MRC-5) cells. In this context, 2OHOA treatment strongly augments SM mass (4.6-fold), restoring the found in MRC-5 cells, while loss phosphatidylethanolamine and phosphatidylcholine is observed (57 30%, respectively). increased was due to rapid highly specific activation synthases...
Abstract : Suicide and depression are associated with an increased density of α 2 ‐adrenoceptors (radioligand receptor binding) in specific regions the human brain. The function these inhibitory receptors involves various regulatory proteins (G i coupling G protein‐coupled kinases, GRKs), which work concert receptors. In this study we quantitated parallel levels immunolabeled 2A brains suicide depressed victims. Specimens prefrontal cortex (Brodmann area 9) were collected from 51 victims 31...
Fatty acid derivatives are abundant in biological membranes, mainly as components of phospholipids and cholesterol esters. Their presence, free or bound to phospholipids, modulates the lipid membrane behavior. The present study shows differential influence C-18 fatty acids (FAs), oleic, elaidic, stearic on structural properties phosphatidylethanolamine (PE). X-ray diffraction PE-FA systems demonstrated that oleic (OA) produced important concentration-dependent alterations structure: it...
Despite recent advances in the development of new cancer therapies, treatment options for glioma remain limited, and survival rate patients has changed little over past three decades. Here, we show that 2-hydroxyoleic acid (2OHOA) induces differentiation autophagy human cells. Compared to current reference drug this condition, temozolomide (TMZ), 2OHOA combated more efficiently and, unlike TMZ, tumor relapse was not observed following treatment. The novel mechanism action is associated with...
Glycogen branching enzyme 1 (GBE1) plays an essential role in glycogen biosynthesis by generating α-1,6-glucosidic branches from α-1,4-linked glucose chains, to increase solubility of the polymer. Mutations GBE1 gene lead heterogeneous early-onset storage disorder type IV (GSDIV) or late-onset adult polyglucosan body disease (APBD). To better understand this enzyme, we crystallized human apo form, and complex with a tetra- hepta-saccharide. The structure reveals conserved amylase core that...
Heterotrimeric G proteins (peripheral proteins) conduct signals from membrane receptors (integral to regulatory localized various cellular compartments. They are in excess over any protein-coupled receptor type on the cell membrane, which is necessary for signal amplification. These facts account large number of protein molecules bound lipids. Thus, protein-lipid interactions crucial their localization, and consequently transduction. In this work, binding subunits model membranes...
Albeit anthracyclines are widely used in the treatment of solid tumors and leukemias, their mechanism action has not been elucidated. The present study gives relevant information about role nonlamellar membrane structures signaling pathways, which could explain how can exert cytocidal without entering cell [Tritton, T. R. & Yee, G. (1982) Science 217, 248-250]. anthracycline daunomycin reduced formation hexagonal (HII) phase (i.e., propensity), stabilizing bilayer structure plasma by a...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRole of membrane lipids in the interaction daunomycin with plasma membranes from tumor cells: implications drug-resistance phenomenaPablo V. Escriba, Antonio Ferrer-Montiel, Jose A. Ferragut, and M. Gonzalez-RosCite this: Biochemistry 1990, 29, 31, 7275–7282Publication Date (Print):August 7, 1990Publication History Published online1 May 2002Published inissue 7 August...
Antimicrobial activity of many AMPs can be improved by lysine-to-arginine substitution due to a more favourable interaction arginine guanidinium moiety with bacterial membranes. In previous work, the structural and functional characterization an amphipathic antimicrobial peptide named RiLK1, including lysine as positively charged amino acids in its sequence, was reported. Specifically, RiLK1 retained β-sheet structure under wide range environmental conditions (temperature, pH, ionic...
<h3>Objective:</h3> To directly evaluate the guanine nucleotide—binding (G) protein subunits α, β, and γ, which are involved in signal transduction of opioid receptors, postmortem brains heroin addicts who had died an opiate overdose. <h3>Methods:</h3> Specimens frontal cortex (Brodmann's area 9) were collected from 11 10 control subjects without a history drug abuse. The biochemical status human brain G during dependence was studied by means immunoblotting techniques. Solubilized proteins...