A5003202016- Neuroscience and Neuropharmacology Research
- Neuroscience and Neural Engineering
- Photoreceptor and optogenetics research
- Cellular transport and secretion
- Lipid Membrane Structure and Behavior
- Receptor Mechanisms and Signaling
- Cannabis and Cannabinoid Research
- Ion channel regulation and function
- Conducting polymers and applications
- Advanced Sensor and Energy Harvesting Materials
- Neurotransmitter Receptor Influence on Behavior
- EEG and Brain-Computer Interfaces
- Advanced Memory and Neural Computing
- Neural dynamics and brain function
- Analytical Chemistry and Sensors
- Sleep and Wakefulness Research
- Circadian rhythm and melatonin
- Urinary Bladder and Prostate Research
- Laser Applications in Dentistry and Medicine
- Erythrocyte Function and Pathophysiology
- Nitric Oxide and Endothelin Effects
- Neurological disorders and treatments
Columbia University Irving Medical Center
2020-2024
Instituto de Investigación Sanitaria del Hospital Clínico San Carlos
2014-2023
Universidad Complutense de Madrid
2011-2022
Columbia University
2019-2022
Hospital Clínico San Carlos
2015
Significance Cannabinoids and their endogenous counterparts, the so-called endocannabinoids, promote neuroprotection in laboratory animals by engaging CB 1 cannabinoid receptors, one of most abundant types receptors brain. However, assessment physiological relevance therapeutic potential receptor neurological diseases is hampered, at least part, lack knowledge neuron-population specificity action. This study shows that a unique well-defined population namely located on glutamatergic...
Synaptic vesicle tethering, priming, and neurotransmitter release require a coordinated action of multiple protein complexes. While physiological experiments, interaction data, structural studies purified systems were essential for our understanding the function individual complexes involved, they cannot resolve how actions integrate. We used cryo-electron tomography to simultaneously image presynaptic lipids at molecular resolution in their native composition, conformation, environment. Our...
Abstract Recording from the human brain at spatiotemporal resolution of action potentials provides critical insight into mechanisms higher cognitive functions and neuropsychiatric disease that is challenging to derive animal models. Here, organic materials conformable electronics are employed create an integrated neural interface device compatible with minimally invasive neurosurgical procedures geared toward chronic implantation on surface brain. Data generated these devices enable...
The second messenger cAMP is an important determinant of synaptic plasticity that associated with enhanced neurotransmitter release. Long-term potentiation (LTP) at parallel fiber (PF)–Purkinje cell (PC) synapses depends on a Ca 2+ -induced increase in presynaptic mediated by -sensitive adenylyl cyclases. However, the upstream signaling and downstream targets involved these events remain poorly understood. It unclear whether generated β-adrenergic receptors (βARs) required for PF–PC LTP,...
The vast majority of neurons within the striatum are GABAergic medium spiny (MSNs), which receive glutamatergic input from cortex and thalamus, form two major efferent pathways: direct pathway, expressing dopamine D1 receptor (D1R-MSNs), indirect D2 (D2R-MSNs). While molecular mechanisms MSN degeneration have been identified in animal models striatal damage, factors that dictate a selective vulnerability D1R-MSNs or D2R-MSNs remain unknown. Here, we combined genetic, chemogenetic,...
Neurotransmitter release is inhibited by metabotropic glutamate type 7 (mGlu7 ) receptors that reduce Ca2+ influx, yet synapses lacking this receptor also produce weaker release, suggesting mGlu7 may prime synaptic vesicles for release. Prolonged activation of with the agonist l-AP4 first reduces and then enhances amplitude EPSCs through a presynaptic effect. The inhibitory response blocked pertussis toxin, while potentiating prevented phospholipase C inhibitor (U73122) an diacylglycerol...
Abstract Chitosan (CS) is a biocompatible, inexpensive organic polymer that increasingly used in neural tissue applications. However, its intrinsic fluorescence has not yet been leveraged to facilitate localization of interface devices, key procedure ensure accurate analysis neurophysiological signals. A process developed enable control mechanical and chemical properties CS‐based composites, generating freestanding films are stable aqueous environments exhibit concentration‐dependent...
Abstract Implantable clinical neuroelectronic devices are limited by a lack of reliable, safe, and minimally invasive methods to wirelessly modulate neural tissue. Here, we address this challenge using organic electrolytic photocapacitors (OEPCs) perform chronic peripheral nerve stimulation via transduction tissue-penetrating deep-red light into electrical signals. The operating principle the OEPC relies on efficient charge generation nanoscale semiconductors comprising nontoxic commercial...
Abstract Cannabinoid receptors mediate short‐term retrograde inhibition of neurotransmitter release, as well long‐term depression synaptic transmission at excitatory synapses. The responses individual nerve terminals in VGLUT 1‐ pH luorin transfected cerebellar granule cells to cannabinoids have shown that prolonged activation cannabinoid type 1 ( CB 1Rs) silences a subpopulation previously active boutons. Adopting combined pharmacological and genetic approach study the molecular mechanisms...
Abstract Interictal epileptiform discharges (IEDs) are ubiquitously expressed in epileptic networks and disrupt cognitive functions. It is unclear whether addressing IED-induced dysfunction could improve epilepsy outcomes as most therapeutics target seizures. We show a model of progressive hippocampal that IEDs produce pathological oscillatory coupling which associated with prolonged, hypersynchronous neural spiking synaptically connected cortex expands the brain territory capable generating...
Abstract Synaptic vesicle tethering, priming, and neurotransmitter release require a coordinated action of multiple protein complexes. While physiological experiments, interaction data, structural studies purified systems were essential for our understanding the function individual complexes involved, they cannot combine high detail with unperturbed organization within cells to resolve how actions integrate. We employed cryo-electron tomography simultaneously image presynaptic lipids at...