A5021862393- Neuroscience and Neuropharmacology Research
- Cannabis and Cannabinoid Research
- Stress Responses and Cortisol
- Pancreatic function and diabetes
- GABA and Rice Research
- Protein Degradation and Inhibitors
- Neurotransmitter Receptor Influence on Behavior
- Memory and Neural Mechanisms
- Histone Deacetylase Inhibitors Research
- Genetic and Kidney Cyst Diseases
- Growth Hormone and Insulin-like Growth Factors
- Amino Acid Enzymes and Metabolism
- Genetics and Neurodevelopmental Disorders
- Genetic Neurodegenerative Diseases
- Adipose Tissue and Metabolism
Centro de Investigación Biomédica en Red
2019-2024
Biomedical Research Networking Center on Neurodegenerative Diseases
2017-2024
Instituto de Salud Carlos III
2023-2024
Universidad Complutense de Madrid
2020-2024
Instituto Ramón y Cajal de Investigación Sanitaria
2017-2024
Universidad Autónoma de Madrid
2020-2021
Abstract The type-1 cannabinoid receptor (CB 1 R) is widely expressed in excitatory and inhibitory nerve terminals, by suppressing neurotransmitter release, its activation modulates neural circuits brain function. While the interaction of CB R with various intracellular proteins thought to alter signaling, identity role these are poorly understood. Using a high-throughput proteomic analysis complemented an array vitro vivo approaches mouse brain, we report that C -terminal, domain interacts...
Astrocytes are known to modulate neuronal activity by gliotransmission and through metabolic regulation. However, the connection between these two processes is still poorly defined. In this work we show that p110α isoform of phosphatidylinositol 3-kinase (PI3K) in astrocytes required for long-term potentiation (LTP) has an impact on learning memory. Using a specific deletion from hippocampal adult mice, found LTP depends astrocytic sustain D-serine levels activation NMDA receptors during...
Insulin-like growth factor-1 (IGF-1) plays a key role in synaptic plasticity, spatial learning, and anxiety-like behavioral processes. While IGF-1 regulates neuronal firing transmission many areas of the central nervous system, its signaling consequences on excitability, animal behavior dependent prefrontal cortex remain unexplored. Here, we show that induces long-lasting depression medium slow post-spike afterhyperpolarization (mAHP sAHP), increasing excitability layer 5 pyramidal neurons...
The vast majority of neurons within the striatum are GABAergic medium spiny (MSNs), which receive glutamatergic input from cortex and thalamus, form two major efferent pathways: direct pathway, expressing dopamine D1 receptor (D1R-MSNs), indirect D2 (D2R-MSNs). While molecular mechanisms MSN degeneration have been identified in animal models striatal damage, factors that dictate a selective vulnerability D1R-MSNs or D2R-MSNs remain unknown. Here, we combined genetic, chemogenetic,...
Cannabinoids, the bioactive constituents of cannabis, exert a wide array effects on brain by engaging Type 1 cannabinoid receptor (CB<sub>1</sub>R). Accruing evidence supports that action relies context-dependent factors, such as biological characteristics target cell, suggesting cell population-intrinsic molecular cues modulate CB<sub>1</sub>R-dependent signaling. Here, using yeast two-hybrid-based high-throughput screening, we identified BiP potential CB<sub>1</sub>R-interacting protein....
Growth-associated protein of 43 kDa (GAP43) is a key cytoskeleton-associated component the presynaptic terminal that facilitates neuroplasticity. Downregulation GAP43 expression has been associated to various psychiatric conditions in humans and evokes hippocampus-dependent memory impairments mice. Despite extensive studies conducted on hippocampal past decades, however, very little known about its roles modulating excitatory versus inhibitory balance other brain regions. We recently...
Abstract The type-1 cannabinoid receptor (CB1R) is widely expressed in both excitatory and inhibitory nerve terminals, its activation, by suppressing neurotransmitter release, modulates neural circuits brain function. While the interaction of CB1R with various intracellular proteins thought to alter signaling, identity role these are poorly understood. Using a high-throughput proteomic analysis complemented an array vitro vivo approaches mouse brain, we report that C-terminal, domain...
Abstract Cereblon/CRBN is a substrate-recognition component of the Cullin4A-DDB1-Roc1 E3 ubiquitin ligase complex. Destabilizing mutations in human CRBN gene cause form autosomal recessive non-syndromic intellectual disability (ARNSID) that modelled by knocking-out mouse Crbn gene. A reduction excitatory neurotransmission has been proposed as an underlying mechanism disease, but intimate factors eliciting this impairment remain mostly unknown. Here we report molecules selectively located on...
Cannabinoids exert pleiotropic effects on the brain by engaging cannabinoid CB1 receptor (CB1R), a presynaptic metabotropic that regulates key neuronal functions in highly context-dependent manner. We have previously shown CB1R interacts with growth-associated protein of 43 kDa (GAP43) and this interaction inhibits function hippocampal excitatory synaptic transmission, thereby impairing therapeutic effect cannabinoids epileptic seizures vivo. However, underlying molecular features remain...
SUMMARY Insulin-like growth factor-1 (IGF-1) plays a key role in synaptic plasticity, degenerative diseases, spatial learning, and anxiety-like behavioral processes. While IGF-1 regulates neuronal activity many areas of the brain, its effect on plasticity animal behavior dependent prefrontal cortex remain unexplored. Here, we show that induces long-lasting depression medium slow post-spike afterhyperpolarization (mAHP sAHP), increasing excitability layer 5 pyramidal neurons infralimbic...