A5064843949- Adipose Tissue and Metabolism
- Eating Disorders and Behaviors
- Neurotransmitter Receptor Influence on Behavior
- Cannabis and Cannabinoid Research
- Regulation of Appetite and Obesity
- Neural dynamics and brain function
- Stress Responses and Cortisol
- Obesity, Physical Activity, Diet
- Behavioral Health and Interventions
- Biochemical effects in animals
Inserm
2019-2020
Université de Bordeaux
2019-2020
Neurocentre Magendie
2019-2020
The lack of intrinsic motivation to engage in, and adhere to, physical exercise has major health consequences. However, the neurobiological bases are still unknown. This study aimed at examining whether endocannabinoid system (ECS) is involved in this process. To do so, we developed an operant conditioning paradigm wherein mice unlocked a running wheel with nose pokes. Using pharmacological tools conditional mutants for cannabinoid type-1 (CB1) receptors, provide evidence that CB1 receptors...
Anorexia nervosa (AN), mostly observed in female adolescents, is the most fatal mental illness. Its core a motivational imbalance between exercise and feeding favor of former. The privileged animal model AN "activity-based anorexia" (ABA) wherein partly starved rodents housed with running wheels at expense feeding. However, ABA bears face construct validity limits, including its inability to specifically assess motivation motivation. As infant/adolescent trauma precipitating factor AN, this...
Physical exercise, which can be addictogenic on its own, is considered a therapeutic alternative for drug craving. Exercise might thus share with drugs the ability to strengthen excitatory synapses onto ventral tegmental area (VTA) dopaminergic neurones, as assessed by ratio of AMPA receptor (AMPAR)-mediated postsynaptic currents (EPSCs) NMDA (NMDAR)-mediated EPSCs. As did acute cocaine, amphetamine, or Δ9 -tetrahydrocannabinol (THC) pretreatments, an 1-h wheel-running session increased...
Wheel running, especially in the homecage, has been widely used to study neurobiology of exercise because animal tends use it voluntarily. However, as for each reward, its consumption (in present case, running performance) does not specifically provide information on incentive value, i.e., extent which animals are motivated run independently from their that reward. This is a major drawback, when focusing governing pathological imbalances between and e.g., feeding (obesity, anorexia nervosa)....