A5055184186- Cannabis and Cannabinoid Research
- Sleep and Wakefulness Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Neuroinflammation and Neurodegeneration Mechanisms
- Traumatic Brain Injury Research
- Neuroscience and Neuropharmacology Research
- Circadian rhythm and melatonin
- HIV Research and Treatment
- Regulation of Appetite and Obesity
- Neonatal and fetal brain pathology
- Neurotransmitter Receptor Influence on Behavior
- Stress Responses and Cortisol
- Neurological Disorders and Treatments
- Redox biology and oxidative stress
- Parasitic infections in humans and animals
- S100 Proteins and Annexins
- Biochemical effects in animals
- Neuroscience of respiration and sleep
- Psychedelics and Drug Studies
- Adipose Tissue and Metabolism
- Sexual Differentiation and Disorders
- Mitochondrial Function and Pathology
- Neuroendocrine regulation and behavior
- Attention Deficit Hyperactivity Disorder
- Electromagnetic Fields and Biological Effects
Universidad Nacional Autónoma de México
2013-2024
Colciencias
2000
Hospital Provincial de Conxo
1988
Background and purpose: Evidence indicates that the endocannabinoid, 2‐arachidonoylglycerol (2‐AG), increases food intake when injected into nucleus accumbens shell (NAcS), thereby potentially activating hypothalamic nuclei involved in regulation. We aimed to evaluate potential orexigenic effects of endocannabinoid anandamide AA5HT, a fatty acid amide hydrolase (FAAH) inhibitor, OMDM‐1, an inhibitor uptake, NAcS, as well effect these treatments on activation nuclei. Experimental approach:...
Anandamide (ANA) alters sleep by increasing the amount of time spent in slow wave 2 (SWS2) and rapid eye movement (REMS) at expense wakefulness (W) rats. In this report, we describe a similar effect ANA when injected itracerebroventricularly (i.c.v.) or into peduriculopontine tegmental nucleus (PPTg) lack an is administered medial preoptic area (MPOA). Furthermore, i.c.v. PPTg administration SR141716A, CB1 antagonist, U73122, PLC inhibitor, 15 min prior to ANA, readily prevents induced...
Systemic inflammation is a crucial factor for microglial activation and neuroinflammation in neurodegeneration. This work aimed at assessing whether previous exposure to systemic potentiates neurotoxic damage by the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) how chronic participates physiopathological mechanisms of Parkinson’s disease. Two different models were employed explore this hypothesis: single administration lipopolysaccharide (sLPS; 5 mg/kg) low doses (mLPS; 100...
Stress is a state of vulnerable homeostasis that alters the physiological and behavioral responses. induces oxidative damage in several organs including brain, liver, kidney, stomach, heart. Preliminary findings suggested magnetic stimulation could accelerate healing processes has been an effective complementary therapy different pathologies. However, mechanism action static fields (SMFs) not well understood. In this study, we demonstrated effects (0.8 mT) restraint stressed animal model,...
The endocannabinoid system is a component of the neuroprotective mechanisms that an organism displays after traumatic brain injury (TBI). A diurnal variation in several components this has been reported. This may influence recovery and survival rate TBI. We have previously reported rats higher if TBI occurs at 1:00 than 13:00. could be explained by system. Here, we describe effects anandamide administration prior to induction two different times day: found reduced neurological damage both...
Cathepsin B is one of the major lysosomal cysteine proteases involved in neuronal protein catabolism. This cathepsin released after traumatic injury and increases death; however, release cystatin C, a inhibitor, appears to be self-protective brain response. Here we describe effect C intracerebroventricular administration rats prior inducing injury. We observed that injection caused dual response post-traumatic recovery: higher doses (350 fmoles) increased bleeding mortality, whereas lower...
Data from our laboratory suggest that recovery a traumatic brain injury depends on the time of day at which it occurred. In this study, we examined whether -induced damage is related to circadian variation in N‐methyl‐d‐aspartate receptor expression rat cortex. We confirmed depended also found motor cortex subunit NR1 exhibited diurnal both control and injury-subjected rats. However, rhythm more pronounced injury—subjected rats, with minimum those injured during nighttime hours. These...
Neurocysticercosis (NCC), a major cause of neurological morbidity worldwide, is caused by the larvae Taenia solium. Cestodes secrete molecules that block Th1 response their hosts and induce Th2 permissive to establishment. Mature microRNAs (miRs) are small noncoding RNAs regulate gene expression participate in immunological processes. To determine participation miRs immune against cysticercosis, we constructed RNA (sRNA) libraries from solium crassiceps. A total 12074504 11779456 sequencing...
The intraperitoneal cysticercosis model with the Taenia crassiceps ORF strain in female BALB/cAnN mice has been widely used to study immune response cysticercosis. During early infection (2 weeks), host develops a non-permissive Th1 response, whereas during late (8 molecules from cysticerci induce Th2 that is permissive parasite growth. modulation of induced by excreted/secreted larval stage parasite. However, there limited information regarding mouse immunological environment infection....
Chromaffin cells exposed to extremely low frequency magnetic fields (ELF MF, 60 Hz, 0.7 mT) differentiate into sympathetic neuron-like cells. This complex process must involve both qualitative and quantitative variations in gene expression. study looks at whether ELF MF treatment provokes changes the global transcription profile of chromaffin cells, using RT-Differential Display method. When expression patterns experimental groups (nerve growth factor (NGF) MF) were compared those receiving...
Traumatic brain injury (TBI) represents a significant public health concern and has been associated with high rates of morbidity mortality. Although several research groups have proposed the use repetitive transcranial magnetic stimulation (rTMS) to enhance neuroprotection recovery in patients TBI, few studies obtained sufficient evidence regarding its effects this population. Therefore, we aimed analyze effect intermediate-frequency rTMS (2 Hz) on behavioral histological following TBI rats....
Background: Traumatic brain injury (TBI) is a severe health problem for which there no specific treatment, leading to neurological or neuropsychological consequences. One of the most described disorders, even after mild TBI (mTBI), depression, related mechanisms involving reactive oxygen species (ROS). The Mucuna pruriens (M. pruriens) plant has various antioxidant, neuroprotective, and anti-inflammatory properties.