A5052295709- Cannabis and Cannabinoid Research
- Neuroscience and Neuropharmacology Research
- Neuroscience of respiration and sleep
- Memory and Neural Mechanisms
- Neurotransmitter Receptor Influence on Behavior
- Neuroinflammation and Neurodegeneration Mechanisms
- Neonatal and fetal brain pathology
- Stress Responses and Cortisol
- Personality Traits and Psychology
- Neurogenesis and neuroplasticity mechanisms
- Sleep and Wakefulness Research
- Peroxisome Proliferator-Activated Receptors
- Receptor Mechanisms and Signaling
- Pancreatic function and diabetes
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Neural and Behavioral Psychology Studies
- Adipose Tissue and Metabolism
- Personality Disorders and Psychopathology
- Neuropeptides and Animal Physiology
- Genetics and Neurodevelopmental Disorders
- Sphingolipid Metabolism and Signaling
- Mitochondrial Function and Pathology
- Neuroendocrine regulation and behavior
- Educational Outcomes and Influences
- Zebrafish Biomedical Research Applications
Universidad de Málaga
2009-2025
Instituto de Investigación Biomédica de Málaga
2012-2023
Universitat de Lleida
2013-2022
Biomedical Research Institute of Lleida
2014-2020
Hospital Regional Universitario de Málaga
2011-2017
Consejo Nacional de Investigaciones Científicas y Técnicas
2013-2015
University of Buenos Aires
2015
Central Institute of Mental Health
2014
Heidelberg University
2014
University Hospital Heidelberg
2014
Intraneuronal accumulation of amyloid β (iAβ) has been linked to mild cognitive impairment that may precede Alzheimer's disease (AD) onset. This neuropathological trait was recently mimicked in a novel animal model AD, the hemizygous transgenic McGill-R-Thy1-APP (Tg(+/-)) rat. The characterization behavioral phenotypes this could provide baseline efficacy for earlier therapeutic interventions. aim present study undertake longitudinal Aβ and comprehensive evaluation rat model. We assessed...
Addiction to major drugs of abuse such as cocaine has been recently linked alterations on adult neurogenesis in the hippocampus. The endogenous cannabinoid system modulated this proliferative response since pharmacological activation/blockade CB1 and CB2 receptors by modulating not only but also cell death brain. In present study, we evaluated whether affects cocaine-induced proliferation . To end examined if blockade either (Rimonabant, 3 mg/kg) or (AM630, (labeled with BrdU), found...
Cocaine is associated with serious health problems including psychiatric co-morbidity. There a need for the identification of biomarkers stratification cocaine-addicted subjects. Several studies have evaluated circulating endocannabinoid-related lipids as inflammatory, metabolic and mental disorders. However, little known in substance use This study characterizes both free N-acyl-ethanolamines (NAEs) 2-acyl-glycerols abstinent cocaine addicts from outpatient treatment programs who were...
We investigated the role of adult hippocampal neurogenesis in cocaine-induced conditioned place preference (CPP) behaviour and functional brain circuitry involved. Adult was pharmacologically reduced with temozolomide (TMZ), mice were tested for CPP to study c-Fos expression hippocampus extrahippocampal addiction-related areas. Correlational multivariate analysis revealed that, under normal conditions, showed widespread connectivity other areas strongly contributed module associated...
Negation has been a long-standing challenge for language models. Previous studies have shown that they struggle with negation in many natural understanding tasks. In this work, we propose self-supervised method to make models more robust against negation. We introduce novel task, Next Sentence Polarity Prediction (NSPP), and variation of the (NSP) task. show BERT RoBERTa further pre-trained on our tasks outperform off-the-shelf versions nine negation-related benchmarks. Most notably,...
Abstract Perinatal asphyxia remains as one of the most important causes death and disability in children, without an effective treatment. Moreover, little is known about long‐lasting behavioral consequences at birth. Therefore, main aim present study was to investigate motor, emotional cognitive functions adult asphyctic rats. Experimental subjects consisted rats born vaginally (CTL), by cesarean section (C+), or following 19 min (PA). At three months age, animals were examined a test...
Oleoylethanolamide (OEA) is an agonist of the peroxisome proliferator-activated receptor α (PPARα) and has been described to exhibit neuroprotective properties when administered locally in animal models several neurological disorder models, including stroke Parkinson's disease. However, there little information regarding effectiveness systemic administration OEA on In present study, OEA-mediated neuroprotection tested vivo vitro 6-hydroxydopamine (6-OH-DA)-induced degeneration. The model was...
Endocannabinoids modulate the glutamatergic excitatory transmission by acting as retrograde messengers. A growing body of studies has reported that both signaling systems in mesocorticolimbic neural circuitry are involved neurobiological mechanisms underlying drug addiction. We investigated whether expression endocannabinoid and prefrontal cortex (PFC) were altered an acute and/or repeated cocaine administration schedule resulted behavioral sensitization. measured protein mRNA main metabolic...
The lysophosphatidic acid LPA1 receptor has recently been involved in the adaptation of hippocampus to chronic stress. absence aggravates stress-induced impairment both hippocampal neurogenesis and apoptosis that were accompanied with hippocampus-dependent memory deficits. Apoptotic death are regulated by oxidative In present work, we studied involvement signaling pathway regulation redox after To this end, used malpar1 knockout (KO) wild-type mice assigned either stress (21 days restraint,...
Continuous environmental stimulation induced by exposure to enriched environment (EE) has yielded cognitive benefits in different models of brain injury. Perinatal asphyxia results from a lack oxygen supply the fetus and is associated with long-lasting neurological deficits. However, effects EE middle-aged rats suffering perinatal are unknown. Therefore, aim present study was assess whether life-long could counteract behavioral alterations asphyctic rats. Experimental groups consisted born...
The present study was designed to investigate the effect of pharmacological inhibition endocannabinoid degradation on behavioural actions dopamine D2/D3 receptor agonist quinpirole in male C57Bl/6J mice. In addition, we studied effects both cocaine-induced psychomotor activation and sensitization. We analysed two main enzymes: fatty acid amide hydrolase (FAAH), using inhibitor URB597 (1 mg/kg); monoacylglycerol lipase (MAGL), URB602 (10 mg/kg). Administration mg/kg) caused a temporal...
Abstract Oleoylethanolamide ( OEA ) is an acylethanolamide that acts as agonist of nuclear peroxisome proliferator‐activated receptor alpha PPARα to exert their biological functions, which include the regulation appetite and metabolism. Increasing evidence also suggests may participate in control reward‐related behaviours. However, direct experimental for role ‐ interaction drug‐mediated behaviours, such cocaine‐induced behavioural phenotypes, lacking. The present study explored its on...