A5031609523- Cannabis and Cannabinoid Research
- Neurotransmitter Receptor Influence on Behavior
- Genetics and Neurodevelopmental Disorders
- Neuroscience and Neuropharmacology Research
- Neuroscience of respiration and sleep
- Sleep and Wakefulness Research
- Alcohol Consumption and Health Effects
- Biochemical effects in animals
- Endoplasmic Reticulum Stress and Disease
- Social Media in Health Education
- Mitochondrial Function and Pathology
- Mobile Health and mHealth Applications
- Diet and metabolism studies
- Health Literacy and Information Accessibility
- Tryptophan and brain disorders
- Sphingolipid Metabolism and Signaling
- Ubiquitin and proteasome pathways
- Substance Abuse Treatment and Outcomes
- Lysosomal Storage Disorders Research
- Forensic Toxicology and Drug Analysis
- Congenital heart defects research
- Lipid metabolism and biosynthesis
- Heart Rate Variability and Autonomic Control
- Coenzyme Q10 studies and effects
- Diet, Metabolism, and Disease
Universitat Oberta de Catalunya
2024
Hospital Doctor José Molina Orosa
2001-2007
Universidad Complutense de Madrid
1997-1999
Recent studies suggest that the endocannabinoid system modulates feeding. Despite existence of central mechanisms for regulation food intake by endocannabinoids, evidence indicates peripheral may also exist. To test this hypothesis, we investigated (1) effects feeding on intestinal anandamide accumulation; (2) (intracerebroventricular) and (intraperitoneal) administration agonist anandamide, synthetic cannabinoid...
The present study was designed to explore the relationship between cannabinoid and opioid receptors in animal models of opioid-induced reinforcement. acute administration SR141716A, a selective central CB1 receptor antagonist, blocked heroin self-administration rats, as well morphine-induced place preference morphine mice. Morphine-dependent animals injected with SR141716A exhibited partial opiate-like withdrawal syndrome that had limited consequences on operant responses for food induced...
ANIMAL models have revealed that psychoactive cannabinoids induce both anxiolytic and anxiety-like reactions which are dose- context-dependent. In the present study we examined acute actions of CB1 cannabinoid receptor antagonist SR 141716A in defensive withdrawal test elevated plus-maze rats. Acute administration (0.1, 1 3 mg kg−1) induced responses anxiety tests, at a dose kg−1. This had no effect on horizontal locomotor activity did not activate hypothalamus–pituitary–adrenal axis,...
RECENT reports have provided evidence of a link between the endogenous brain cannabinoid system and central opioid systems. Here we report that selective CB1 receptor antagonist SR 141716A induced behavioral endocrine alterations associated with opiate withdrawal in morphine-dependent animals dose-dependent manner naloxone an syndrome made cannabinoid-dependent by repeated administration potent agonist HU-210. Additionally μ-opioid mRNAs were co-localized areas relevant for such as nucleus...
Lysophosphatidic acid (LPA) is a simple phospholipid with extracellular signaling properties mediated by specific G protein–coupled receptors. At least 2 LPA receptors, LPA1 and LPA2, are expressed in the developing brain, former enriched neurogenic ventricular zone (VZ), suggesting normal role neurogenesis. Despite numerous studies reporting effects of exogenous using vitro neural models, first loss-of-function mutants reported did not show gross cerebral cortical defects 50% that survived...
Abstract The endocannabinoid system is involved in a variety of effects drugs misuse, and blockade the cannabinoid CB1 receptor by selective antagonists elicits marked reductions opioid alcohol self‐administration. present study was designed to extend our knowledge role modulation misuse vulnerability rats. Accordingly, using nonselected Wistar rats genetically selected Marchigian Sardinian alcohol‐preferring (msP) rats, we investigated effect antagonist SR141716A on operant...
Abstract Fragile X syndrome is the most common form of inherited mental retardation in humans. It originates from loss expression 1 (FMR1) gene, which results absence protein. However, biochemical mechanisms involved pathological phenotype are mostly unknown. The availability FMR1‐knockout mouse model offers an excellent system to study alterations related brain abnormalities syndrome. We show for first time that brains Fmr1‐knockout mice, a validated syndrome, display higher levels reactive...
Fragile X syndrome is the most common form of inherited mental retardation. It typically caused by a mutation mental-retardation 1 (Fmr1) gene. To better understand role Fmr1 gene and its product, fragile protein in central nervous system functions, an fmr1 knockout mouse that deficient was bred. In present study, retardation 1-knockout wild-type mice are used to determine behaviour oxidative stress alterations, including reduced glutathione, oxidized glutathione thiobarbituric acid-reactive...
Background The rise of digital health services, especially following the outbreak COVID-19, has led to a need for literacy policies that respond people’s needs. Spain is country with highly developed infrastructure, but there are currently no tools available measure fully. A well-thought-through questionnaire strong psychometric properties such as eHealth Literacy Questionnaire (eHLQ) important assess levels, in context fast-growing field health. Objective This study aims adapt eHLQ and...
Natural and synthetic cannabinoid receptor agonists have been described to exert profound effects on both the neuroendocrine integration functional responses of immune system. In present study, Wistar rats were exposed highly potent agonist HU-210 (1, 5 25 microg/kg) during gestation lactation ensuing several endocrine parameters adult male offspring analyzed. Perinatal exposure partially affected distribution lymphocyte subpopulations in spleen peripheral blood. The major changes observed...
Fragile X syndrome (FXS) is an inherited neurodevelopmental condition characterised by behavioural, learning disabilities, phisical and neurological symptoms. In addition, important degree of comorbidity with autism also present. Considered a rare disorder affecting both genders, it first becomes apparent during childhood displays language delay behavioural Main aim: To show whether the combination 10 mg/kg/day ascorbic acid (vitamin C) α-tocopherol E) reduces FXS symptoms among male...
<sec> <title>BACKGROUND</title> The rise of digital health services, especially following the outbreak COVID-19, has led to a need for literacy policies that respond people’s needs. Spain is country with highly developed infrastructure, but there are currently no tools available measure fully. A well-thought-through questionnaire strong psychometric properties such as eHealth Literacy Questionnaire (eHLQ) important assess levels, in context fast-growing field health. </sec>...
La adicción a drogas es una enfermedad crónica, recidivante, que se caracteriza por la pérdida del control sobre el uso de sustancia, pasa ocupar un lugar preferencial en vida individuo. Es alteran los mecanismos conducta, especial, atañen al motivacional y emocional. Este artículo pretende revisar papel juegan las estructuras encefálicas participan organización conductas motivadas, agrupan bajo nombre genérico sistema límbico. participa tanto procesamiento fenómenos agudos recompensa...