A5111881615- Neurotransmitter Receptor Influence on Behavior
- Cannabis and Cannabinoid Research
- Neuroscience and Neuropharmacology Research
- Cardiac tumors and thrombi
- Advanced Radiotherapy Techniques
- Advanced X-ray and CT Imaging
- Neuropeptides and Animal Physiology
- Sleep and Wakefulness Research
- Radiation Dose and Imaging
- Radiation Therapy and Dosimetry
- Receptor Mechanisms and Signaling
- Radiomics and Machine Learning in Medical Imaging
Hospital Universitario Ramón y Cajal
2024-2025
Ministerio de Ciencia y Tecnología
2005
Universidad Complutense de Madrid
1991-2005
The present study was designed to explore the relationship between cannabinoid and opioid receptors in animal models of opioid-induced reinforcement. acute administration SR141716A, a selective central CB1 receptor antagonist, blocked heroin self-administration rats, as well morphine-induced place preference morphine mice. Morphine-dependent animals injected with SR141716A exhibited partial opiate-like withdrawal syndrome that had limited consequences on operant responses for food induced...
The present study investigated spontaneous and quinpirole-induced motor responses of in rats, following withdrawal from chronic treatment with the potent cannabinoid agonist HU-210. Withdrawal HU-210 (20 μg/kg daily, 14 days) produced a decrease activity at 1 2 days enhanced hyperactivity induced by acute administration dopamine D2 quinpirole (0.5 mg/kg) 4 after end treatment. Administration on day stereotyped jumping behaviour. These results suggest that exposure to agonists could induce...
Los cannabinoides son compuestos psicoactivos presentes en el cannabis y que actúan sistema nervioso a través de receptores específicos membrana, los CB-1. Estos están situados neuronas muchos circuitos encefálicos, incluyendo recompensa cerebral. Este es clave para entender la conducta adictiva, él forman parte las dopaminérgicas mesotelencefálicas, así como algunas peptidérgicas entre destacan encefalinérgicas. cannabinoides, al igual resto drogas abuso, activan mesotelencefálicas...
Purpose: A comparison of different machine learning models to discriminate adrenal incidentalomas by CT studies was performed. Methods: Sixty-two features were obtained from a sample 61 using the free license software LIFEx and 19 radiomic performed with feature selection methods obtain most efficient determination possible malignancy. For all them, four cross-validation evaluated. Adenoma contouring in duplicate radiologists evaluating both groups. Results: ROC AUC between 0.42 (0.09-0.81)...
El sistema cannabinoide endogeno es un nuevo de comunicación intercelular compuesto por los receptores para cannabinoides CB-1 y CB-2 varios transmisores lipidicos, que incluyen a la anandamida el 2-araquidonilglicerol. Los CB1 CB2 son diana farmacológica naturales, compuestos psicoactivos presentes en preparaciones Cannabis sativa. se consumen como droga ilegal. La investigacion modelos animales ha constatado inducen cambios sistemas cerebrales recompensa, especial sobre las neuronas...