A5073282860- Radiopharmaceutical Chemistry and Applications
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Medical Imaging and Pathology Studies
- Medical Imaging Techniques and Applications
- Monoclonal and Polyclonal Antibodies Research
- Peptidase Inhibition and Analysis
- Metal complexes synthesis and properties
- Lanthanide and Transition Metal Complexes
- Organometallic Compounds Synthesis and Characterization
- Cell Adhesion Molecules Research
- Prostate Cancer Treatment and Research
- Chemical Reactions and Isotopes
- Bone health and treatments
- Crystal structures of chemical compounds
- Lung Cancer Research Studies
- Chemical Synthesis and Analysis
- Chemical Synthesis and Characterization
- Blood properties and coagulation
- Radioactive element chemistry and processing
- Organometallic Complex Synthesis and Catalysis
- Lung Cancer Treatments and Mutations
- Asymmetric Hydrogenation and Catalysis
- Chemokine receptors and signaling
- Immunotherapy and Immune Responses
Institute of Condensed Matter Chemistry and Technologies for Energy
2016-2024
National Research Council
2020
University of Padua
2010-2018
Istituto di Farmacologia Traslazionale
2017
Nihon Medi-Physics (Japan)
2010
We report the synthesis of three optical probes (Eu3+⊂1, Eu3+⊂2, and Eu3+⊂3) having a luminescent Eu complex (signaling unit) bonded in different positions to folic acid (FA), folate receptor (FR) targeting unit. The structures two regioisomers Eu3+⊂1 Eu3+⊂2 were assigned by mass spectrometric experiments. properties stability these assessed phosphate-buffered saline, cell culture medium, rat serum, cellular lysate, results indicated that they are chemically photophysically stable....
A library of mononuclear [Ga III (DTC) 3 ] complexes, where DTC is an alicyclic or a linear dithiocarbamate chelator, with marked cytotoxic activity reported. Results pave the way for development new anticancer agents.
99mTc(N)-DBODC5 is a cationic mixed compound under clinical investigation as potential myocardial imaging agent. In spite of this, analogously to the other 99mTc-agents, presents relatively low first-pass extraction. Thus, modification 99mTc(N)-DBODC(5) direct increase its extraction keeping unaltered favorable properties would be desirable. This work describes synthesis and biological evaluation series novel 99mTc-nitrido complexes, general formula [99mTcN(DTC-Ln)(PNP)]+ (DTC-Ln= alicyclic...
New integrin-selective molecules suitable for therapeutic or imaging purposes are currently of interest in development effective personalized medical platforms. RGDechi is a bifunctional peptide selective integrin αvβ3. Herein, and three truncated derivatives functionalized with cysteine (1-4) were synthesized labeled the [99mTc][Tc(N)PNP43]-synthon ([PNP43 = (CH3)2P(CH2)2N(C2H4OCH3)(CH2)2P(CH3)2]) (99mTc1-4) as basis recognition. The pharmacological parameters all radiolabeled peptides...
Abstract The clinical translation of theranostic 177 Lu-radiopharmaceuticals based on inhibitors the prostate-specific membrane antigen (PSMA) has demonstrated positive responses in patients with advanced prostate cancer (PCa). However, challenges still remain, particularly regarding their pharmacokinetic and dosimetric properties. We developed a potential PSMA-immunotheranostic agent by conjugation single-chain variable fragment IgGD2B antibody (scFvD2B) to DOTA, obtain Lu-labelled better...
The synthesis and characterization of a new series neutral, six-coordinated mixed-ligand compounds [MIII(PS)2(L)] (M = Re; 99Tc), where PS is bis(arylalkyl)- or trialkylphosphinothiolate L dithiocarbamate, are reported. Stable complexes were easily synthesized, in good yield, starting from precursors the metal was different oxidation states (III, V, VII), involving ligand-exchange and/or redox-substitution reactions. characterized by elemental analysis, positive-ion electrospray ionization...
The reactivities of diphosphinoamine ligands [(Ph<sub>2</sub>PCH<sub>2</sub>CH<sub>2</sub>)<sub>2</sub>NR] toward rhenium(<sc>iii</sc>,<sc>v</sc>) precursors have been studied. obtained complexes fully characterized.
The incorporation of bioactive molecules into a water-soluble [99mTc][Tc(N)(PNP)]-based mixed compound is described. method, which exploits the chemical properties new [99mTc][Tc(N)(PNP3OH)]2+ synthon [PNP3OH = N,N-bis(di-hydroxymethylenphosphinoethyl)methoxyethylamine], was successfully applied to labeling small, medium (cysteine-functionalized biotin and c-RGDfK pentapeptide), large molecules. Apomyoglobin chosen as model protein derivatized via site-specific enzymatic reaction catalyzed...
[99mTc][TcN-DBODC(5) is the lead candidate of a class cationic complexes proposed as myocardial imaging agents (MPIAs). Phase I clinical studies showed that its properties were comparable to those commercially available agents. Thus, modification [99mTc]TcN-DBODC(5), directed obtain an ideal without interference from adjacent organ activities, desirable. This work describes pharmacological and pharmacokinetic development four new general formula [99mTc][Tc(N)(DASD)(PNP n)]+, [99mTc]TcN-DASD(...
The coordination properties of isopropylxanthate (i-Pr-Tiox) and pyridine-2-thiolate (PyS) toward the [M(PS)2]+ moiety (M = Re 99mTc; PS phosphinothiolate) were investigated. Synthesis full characterization [Re(PS2)2(i-Pr-Tiox)] (Re1), [Re(PSiso)2(i-Pr-Tiox)] (Re2), [Re(PS2)2(PyS)] (Re3), [Re(PSiso)2(PyS)] (Re4), where PS2 2-(diphenylphosphino)ethanethiolate PSiso 2-(diisopropylphosphino)ethanethiolate, structural X-ray analysis complex Re3 carried out. 99mTc analogues complexes Re2 (99mTc2)...
In this work, we explored the ability of N-methyl-S-methyl dithiocarbazate ([H2N-N(CH3)C(=S)SCH3]; DTCZ) to form coordination complexes with copper starting from different (II, I) sources. Data proved that type used salt affects stoichiometry and structure obtained complexes. Copper general empirical formula [Cu(DTCZ)Cl2] (1), [Cu(DTCZ)2NO3]NO3 (2), [Cu(DTCZ)2(OH2)]SO4 (3), [Cu(DTCZ)2]PF6 (4), [Cu(DTCZ)(PPh3)2]NO3 (5) [Cu(DTCZ)2]Br (6) were synthesized in high yield characterized by...
Abstract α‐Melanocyte stimulating hormone (α‐MSH) derivatives target the melanocortin‐1 receptor (MC1R) specifically and selectively. In this study, α‐MSH‐derived peptide NAP‐NS1 (Nle‐Asp‐His‐ d ‐Phe‐Arg‐Trp‐Gly‐NH 2 ) with without linkers was conjugated 5‐(bis(pyridin‐2‐ylmethyl)amino)pentanoic acid (DPA‐COOH) labeled [ 99m Tc]Tc‐tricarbonyl by two methods. With one‐pot method labeling faster than two‐pot method, while obtaining similarly high yields. Negligible trans‐chelation stability in...
A general procedure for the preparation of a new class neutral six-coordinated mixed ligand [(99m)Tc(III)(PS)2(Ln)] compounds (PS = trisalkyl-phosphino-thiolate; Ln dithiocarbamate) is reported as well their in vitro stability and ex vivo tissue distribution studies. [(99m)Tc(PS)2(Ln)] complexes were prepared high yield nearly physiologic conditions following one-pot procedure. For instance, chemical identity [(99m)Tc(PSiso)2(L1)] (PSiso 2-(diisopropylphosphino)ethanethiol; L1 pyrrolidine...
In the field of angiogenesis, small cyclic pentapeptides containing RGD motif are playing a relevant role for their high affinity and specificity integrin receptors possibility to act at both therapeutic diagnostic level by inhibiting pathological angiogenesis serving as shuttles deliver imaging-probe including SPECT/PET radionuclides specific tissues. last decade, several new protocols were reported in literature direct synthesis RDG either solution or SPPS. Here, we have elaborated tested...
Background: The [99mTc][Tc(N)(PNP)] system, where PNP is a bisphosphinoamine, an interesting platform for the development of tumor 'receptor-specific' agents. Here, we compared reactivity and impact three [Tc(N)(PNP)] frameworks on stability, receptor targeting properties, biodistribution, metabolism corresponding [99mTc][Tc(N)(PNP)]-tagged cRGDfK peptide to determine best performing agent select framework useful preparation [99mTc][Tc(N)(PNP)]-housing molecular Methods: pentapeptide was...