A5004035773- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Organometallic Compounds Synthesis and Characterization
- Radiopharmaceutical Chemistry and Applications
- Crystal structures of chemical compounds
- Prostate Cancer Treatment and Research
- Metal complexes synthesis and properties
- Peptidase Inhibition and Analysis
- Monoclonal and Polyclonal Antibodies Research
- Polyoxometalates: Synthesis and Applications
Institute of Condensed Matter Chemistry and Technologies for Energy
2023-2024
University of Padua
2022
A library of mononuclear [Ga III (DTC) 3 ] complexes, where DTC is an alicyclic or a linear dithiocarbamate chelator, with marked cytotoxic activity reported. Results pave the way for development new anticancer agents.
In this work, we explored the ability of N-methyl-S-methyl dithiocarbazate ([H2N-N(CH3)C(=S)SCH3]; DTCZ) to form coordination complexes with copper starting from different (II, I) sources. Data proved that type used salt affects stoichiometry and structure obtained complexes. Copper general empirical formula [Cu(DTCZ)Cl2] (1), [Cu(DTCZ)2NO3]NO3 (2), [Cu(DTCZ)2(OH2)]SO4 (3), [Cu(DTCZ)2]PF6 (4), [Cu(DTCZ)(PPh3)2]NO3 (5) [Cu(DTCZ)2]Br (6) were synthesized in high yield characterized by...
Previously, we demonstrated that the 177Lu-labeled single-chain variable fragment of an anti-prostate-specific membrane antigen (PSMA) IgG D2B antibody (scFvD2B) showed higher prostate cancer (PCa) cell uptake and tumor radiation doses compared to Glu-ureide-based PSMA inhibitory peptides. To obtain a 99mTc-/177Lu-scFvD2B theranostic pair, this research aimed synthesize biochemically characterize novel 99mTc-scFvD2B radiotracer. The scFvD2B-Tag scFvD2B fragments were produced purified. Then,...