A5034545273- Schizophrenia research and treatment
- Tryptophan and brain disorders
- Bipolar Disorder and Treatment
- Hallucinations in medical conditions
- Menopause: Health Impacts and Treatments
- Diet and metabolism studies
- Parkinson's Disease Mechanisms and Treatments
- Child and Adolescent Psychosocial and Emotional Development
- Mental Health Research Topics
- Functional Brain Connectivity Studies
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Vestibular and auditory disorders
- Transcranial Magnetic Stimulation Studies
- Mental Health and Psychiatry
- Inflammasome and immune disorders
- Genetic Neurodegenerative Diseases
University Medical Center Utrecht
2015-2024
Heidelberg University
2024
University Hospital Heidelberg
2024
Utrecht University
2020
We examined the course of illness over a 12-month period in large, international multi-center cohort people with first-episode schizophrenia spectrum disorder (FES) naturalistic, prospective study (PSYSCAN). Patients first episode schizophrenia, schizoaffective (depressive type) or schizophreniform were recruited at 16 institutions Europe, Israel and Australia. Participants (N = 304) received clinical treatment as usual throughout study. The mean age was 24.3 years (SD 5.6), 67 % male. At...
There is ample evidence that inflammatory processes play a role in the pathophysiology of schizophrenia. Randomized controlled trials have shown benefit some (but not all) anti-inflammatory drugs on symptom severity. So far, these been given for relatively short period. Simvastatin combines well-established vascular protection with reduction status brain, thus offering an attractive potential to further improve treatment schizophrenia and related disorders.We are currently undertaking...
Abstract Background and Hypotheses In the past 2 decades, substantial effort has been put into research on therapeutic options for people at ultra-high risk (UHR) developing a first episode of psychosis (FEP), focusing omega-3 polyunsaturated fatty acids (PUFAs) in preventing transition to psychosis. Despite an initial positive finding, subsequent studies failed find beneficial effect. The current study aimed further investigate effect PUFAs UHR, determine whether this line is worth...
Although acute psychotic symptoms are often reduced by antipsychotic treatment, many patients with schizophrenia impaired in daily functioning due to the persistence of negative and cognitive symptoms. Raloxifene, a Selective Estrogen Receptor Modulator (SERM) has been shown be an effective adjunctive treatment schizophrenia. Yet, there is paucity evidence for raloxifene efficacy men premenopausal women. We report design study that aims replicate earlier findings concerning augmentation...
Several multivariate prognostic models have been published to predict outcomes in patients with first episode psychosis (FEP), but it remains unclear whether those predictions generalize independent populations. Using a subset of demographic and clinical baseline predictors, we aimed develop externally validate different predicting functional outcome after FEP the context schizophrenia-spectrum disorder (FES), based on previously cross-validation machine learning pipeline. A crossover...
Early detection and intervention in individuals at risk for developing psychosis have become a priority many clinical services around the world. Limited naturalistic evidence is available on whether ultra-high (UHR) effective by means of reducing improving functioning.We compared functioning scores over 5.9 (±7.7) months time between UHR (n = 61) help-seeking adolescents without specific profile (general adolescent population [HSP]; n 82) aged 12 to 25 years receiving psychological...
Previous research provided evidence that 2 mA transcranial direct current stimulation (tDCS) can alleviate treatment-resistant auditory hallucinations (AH). However, results from large sample trials are needed to confirm these results. In a relatively size, this randomized double-blind placebo-controlled trial investigates the efficacy of tDCS on hallucinations, general symptomology psychotic disorders as well cognitive functioning. Fifty-four patients with AH received twice daily or sham...