A5007639772- Schizophrenia research and treatment
- Psychosomatic Disorders and Their Treatments
- Mental Health and Psychiatry
- Child and Adolescent Psychosocial and Emotional Development
- Child Abuse and Trauma
- Functional Brain Connectivity Studies
- Tryptophan and brain disorders
- Personality Disorders and Psychopathology
- Mental Health Research Topics
- Hallucinations in medical conditions
- Obsessive-Compulsive Spectrum Disorders
- Treatment of Major Depression
- Health Systems, Economic Evaluations, Quality of Life
- Bipolar Disorder and Treatment
- Advanced Neuroimaging Techniques and Applications
- Maternal Mental Health During Pregnancy and Postpartum
- Electroconvulsive Therapy Studies
- Pharmaceutical studies and practices
- Stress Responses and Cortisol
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Inflammasome and immune disorders
- Transcranial Magnetic Stimulation Studies
- Cholinesterase and Neurodegenerative Diseases
- Parkinson's Disease Mechanisms and Treatments
- Child and Adolescent Health
University Medical Center Utrecht
2013-2025
Utrecht University
2011-2025
University Medical Center Groningen
2018-2025
University of Groningen
2018-2025
University of Manchester
2025
Greater Manchester Mental Health NHS Foundation Trust
2025
Manchester Academic Health Science Centre
2025
University of Sheffield
2025
Mental Health Services
2024
Trimbos Institute
2024
Abstract Language deviations are a core symptom of schizophrenia. With the advances in computational linguistics, language can be easily assessed exact and reproducible measures. This study investigated how characteristics relate to schizophrenia diagnosis, symptom, severity integrity white matter tracts patients with healthy controls. Spontaneous speech was recorded diffusion tensor imaging performed 26 22 We were able classify both groups sensitivity 89% specificity 82%, based on mean...
Although epidemiological studies report that hallucinations occur in 6-15% of the general population, little is known about their phenomenology. To overcome this paucity, study investigates phenomenological characteristics by using a nationally promoted online survey to assess hallucination phenomenology four sensory modalities, through self-report version Questionnaire for Psychotic Experiences (QPE), 10,448 participants (aged 14-88 years). The was assessed if reportedly occurred past...
Cognitive impairment is a core feature of schizophrenia, which predictive for functional outcomes and is, therefore, treatment target in itself. Yet, literature on efficacy different pharmaco-therapeutic options inconsistent. This quantitative review provides an overview studies that investigated potential cognitive enhancers schizophrenia. We included pharmacological agents, neurotransmitter systems evaluated their overall functioning seven separate domains. In total, 93 with 5630 patients...
Abstract Background Antipsychotic medication is effective for symptomatic treatment in schizophrenia-spectrum disorders. After symptom remission, continuation of antipsychotic associated with lower relapse rates and severity compared to dose reduction/discontinuation. Therefore, most guidelines recommend at least 1 year. Recently, however, these have been questioned as one study has shown that more patients achieved long-term functional remission an early discontinuation condition—a finding...
Symptoms that are linked to psychosis also experienced by individuals who not in need of care. In the present study, cortical thickness was investigated these individuals. Fifty with non-clinical auditory verbal hallucinations (most them other psychotic symptoms), 50 patients a disorder and hallucinations, healthy control subjects underwent structural magnetic resonance imaging. Data were analysed using FreeSurfer. Cortical pars orbitalis, paracentral lobule, fusiform gyrus inferior temporal...
Studies investigating the underlying mechanisms of hallucinations in patients with schizophrenia suggest that an imbalance top-down expectations v. bottom-up processing underlies these errors perception. This study evaluates this hypothesis by testing if individuals drawn from general population who have had auditory (AH) more misperceptions language perception than those never hallucinated.We used online survey to determine presence hallucinations. Participants filled out Questionnaire for...
Abstract Background Childhood trauma increases risk for psychopathology and cognitive impairment. Prior research mainly focused on the hippocampus amygdala in single diagnostic categories. However, other brain regions may be impacted by as well, effects independent of diagnosis. This cross-sectional study investigated cortical subcortical gray matter volume relation to childhood severity. Methods We included 554 participants: 250 bipolar-I patients, 84 schizophrenia-spectrum patients 220...
Schizophrenia-spectrum disorders (SSD) are associated with increased inflammatory markers, both in brain and periphery. Augmentation drugs that lower this pro-inflammatory status may improve clinical presentation. Simvastatin crosses the blood-brain barrier, has anti- neuroprotective effects reduces metabolic syndrome. In study, we investigated if 12 months of simvastatin augmentation can symptoms cognition patients early SSD. This double-blind placebo-controlled trial included 127 SSD...
Abstract Background Cognitive deficits may be characteristic for only a subgroup of first-episode psychosis (FEP) and the link with clinical functional outcomes is less profound than previously thought. This study aimed to identify cognitive subgroups in large sample FEP using clustering approach healthy controls as reference group, subsequently linking outcomes. Methods 204 patients were included. Hierarchical cluster analysis was performed baseline brief assessment cognition schizophrenia...