A5071265938- Pharmacology and Obesity Treatment
- Diet and metabolism studies
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Schizophrenia research and treatment
- Diabetes Treatment and Management
- Autism Spectrum Disorder Research
- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Genetic Associations and Epidemiology
- Hormonal Regulation and Hypertension
- Genetics and Neurodevelopmental Disorders
- Mental Health Research Topics
- Advanced MRI Techniques and Applications
- Pharmacogenetics and Drug Metabolism
- Pharmaceutical studies and practices
- RNA regulation and disease
- Metabolism, Diabetes, and Cancer
- Treatment of Major Depression
- Child Development and Digital Technology
- Hypothalamic control of reproductive hormones
- Fetal and Pediatric Neurological Disorders
Maastricht University
2020-2024
(1) Background Pharmacological treatment for psychiatric disorders has shown to only be effective in about one-third of patients, as it is associated with frequent failure, often because side effects, and a long process trial-and-error pharmacotherapy until an tolerable found. This notion emphasizes the urgency personalized medicine approach psychiatry. (2) Methods prospective patient- rater-blinded, randomized, controlled study will investigate effect dose-adjustment antidepressants...
Background Triple X syndrome (TXS) is caused by aneuploidy of the chromosome and associated with impaired social functioning in children; however, its effect on emotion recognition adults poorly understood. Aims The aim this study was to investigate TXS. Method This cross-sectional cohort designed compare between TXS ( n = 34) an age-matched control group 31). Social assessed Adult Behavior Checklist Responsiveness Scale for Adults. Emotion Recognition Task Cambridge Neuropsychological Test...
Abstract 47,XXX (Triple X syndrome) is a sex chromosome aneuploidy characterized by the presence of supernumerary in affected females and associated with variable cognitive, behavioral, psychiatric phenotype. The effect on intracortical microstructure currently unknown. Therefore, we conducted 7 Tesla structural MRI compared T1 (ms), as proxy for myelin (ICM), across laminae 21 adult women 22 age-matched typically developing using laminar analyses. Relationships between phenotypic traits...
Abstract Background Antipsychotic-induced weight gain (AIWG) represents a significant clinical challenge for both patients and clinicians, requiring appropriate interventions to prevent or reverse in using antipsychotics. Glucagon-like peptide 1 (GLP-1) agonists represent novel approach the management of obesity that has recently attracted considerable attention. Semaglutide (a GLP-1 agonist) been demonstrated result notable loss. The present study investigates whether semaglutide is equally...
Triple X syndrome (47,XXX) is a relatively common sex chromosomal aneuploidy characterized by the presence of supernumerary chromosome in females and has been associated with variable cognitive, behavioural psychiatric phenotype. 47,XXX may serve as suitable model for studying effect genetic architecture on brain morphology. Previous studies have shown alterations structure particularly childhood adolescence. In this study, we examined subcortical cortical morphology adult women using...
Triple X syndrome (TXS, also known as trisomy or 47,XXX) has been associated with impaired overall neurocognitive functioning in children and relatively young adults. However, adults TXS is poorly understood. The aim of this study was, therefore, to examine cognitive TXS. Methods: In cross-sectional study, data were collected from 34 adult women (mean age = 32.9; SD 13.1) 31 controls 34.9; 13.7). General intellectual functioning, semantic/verbal memory, visual/episodic psychomotor speed,...
Women with triple X syndrome (TXS) have an extra chromosome. TXS appeared to be associated psychiatric disorders in biased or underpowered studies.This study aims describe the prevalence of adults a relatively large and less group participants.In this cross-sectional study, data were collected from 34 women (mean age = 32.9; s.d. 13.1) 31 controls 34.9; 13.7). Psychiatric assessed using MINI International Neuropsychiatric Interview (MINI) adult behavior checklist (ABCL). Trait state anxiety...
Several multivariate prognostic models have been published to predict outcomes in patients with first episode psychosis (FEP), but it remains unclear whether those predictions generalize independent populations. Using a subset of demographic and clinical baseline predictors, we aimed develop externally validate different predicting functional outcome after FEP the context schizophrenia-spectrum disorder (FES), based on previously cross-validation machine learning pipeline. A crossover...
Abstract Triple X syndrome is a sex chromosomal aneuploidy characterized by the presence of supernumerary chromosome, resulting in karyotype 47,XXX affected females. It has been associated with variable cognitive, behavioral, and psychiatric phenotype, but little known about its effects on brain function. We therefore conducted 7 T resting-state functional magnetic resonance imaging compared data 19 adult individuals 21 age-matched healthy control women using independent component analysis...
Abstract Background In recent years, antipsychotic-induced weight gain (AIWG) has gained more attention in research. Although interventions to prevent are currently being investigated, AIWG remains a major problem for both patients and clinicians often results poor treatment adherence, decrease quality of life. Furthermore, schizophrenia is associated with higher mortality rates decreased life expectancy. Recently, some new antipsychotic drugs have been introduced that hypothesised entail no...
Abstract Background Antipsychotic (AP) medication is associated with metabolic dysregulation, increasing the risk for weight gain. Previously, we showed that all antipsychotics are related body gain and there was a time effect, longer AP taken more (Bak, Fransen, Janssen, van Os, & Drukker, 2014). This study included data from 1999–2013. The aim of this to up-date previous on by extending search 1960 – July 2019. So, older studies before 2000 were in as well AP’s after 2014. differences...