A5002804671- Stress Responses and Cortisol
- Bipolar Disorder and Treatment
- Tryptophan and brain disorders
- Treatment of Major Depression
- Child and Adolescent Psychosocial and Emotional Development
- Psychology and Mental Health
- Hormonal Regulation and Hypertension
- Schizophrenia research and treatment
- Adrenal Hormones and Disorders
- Child Abuse and Trauma
- Electroconvulsive Therapy Studies
- Maternal Mental Health During Pregnancy and Postpartum
- Health, Nursing, Elderly Care
- Electrolyte and hormonal disorders
- Youth, Drugs, and Violence
- Obsessive-Compulsive Spectrum Disorders
- Functional Brain Connectivity Studies
- Occupational Health and Burnout
- Resilience and Mental Health
- Birth, Development, and Health
- Neuroendocrine regulation and behavior
- Mental Health Research Topics
- Personality Disorders and Psychopathology
- Advanced MRI Techniques and Applications
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
King's College London
2016-2025
South London and Maudsley NHS Foundation Trust
2014-2025
Bethlem Royal Hospital
2009-2024
Union des Industries Ferroviaires Européennes
2023
Universidade Federal de São Paulo
1997-2022
King's College - North Carolina
2020
Universidade de São Paulo
2010-2019
Universidade de Ribeirão Preto
2009-2018
Sociedade Brasileira de Neurociências e Comportamento
2017
The King's College
2013-2017
We evaluate the association between subtypes of early life stress (ELS; sexual abuse, physical emotional neglect, and neglect) psychiatric disorders in adults. The sample was composed 81 adult patients treated at Day Hospital Unit Brazil. were assessed using Mini International Neuropsychiatric Interview according to diagnostic criteria Diagnostic Statistical Manual Mental Disorders, Fourth Edition. presence ELS confirmed by Childhood Trauma Questionnaire, which investigates abuse neglect...
Background People with severe depressive illness have raised levels of cortisol and reduced glucocorticoid receptor function. Aims To obtain a physiological assessment hypothalamic–pituitary–adrenal (HPA) axis feedback status in an in-patient sample depression to relate this prospectively determined treatment resistance. Method The prednisolone suppression test was administered 45 in-patients assessed as resistant two or more antidepressants 46 controls, prior intensive multimodal treatment....
Abstract Background Ketamine is a novel and exciting putative antidepressant medication for patients with treatment-resistant depression. A complication commonly seen in frequent heavy recreational use of ketamine ulcerative cystitis, which presents lower urinary tract symptoms (LUTS) upper renal damage can be over 25% regular users. Although Ketamine-induced cystitis (KIC) recognised ketamine, its occurrence therapeutic depression has so far not been reported. The exact pathogenesis KIC...
(1) Background Pharmacological treatment for psychiatric disorders has shown to only be effective in about one-third of patients, as it is associated with frequent failure, often because side effects, and a long process trial-and-error pharmacotherapy until an tolerable found. This notion emphasizes the urgency personalized medicine approach psychiatry. (2) Methods prospective patient- rater-blinded, randomized, controlled study will investigate effect dose-adjustment antidepressants...
The purpose of the paper was to conduct a systematic review early life stress and its association with psychiatric disorders in adulthood.The occurrence has lasting negative consequences on individual, psychopathology onset one most important consequences.The degree is associated severity disability adulthood.Methodology: We conducted search two databases (PubMed SciELO), limited time span 1990-2010, using following keywords: child abuse, maltreatment, stress, disorders.Thirty-one papers...
Considerable evidence from various studies suggests a preeminent role for early adverse experiences in the development of psychopathology, especially depression.The most recent reviewed herein suggest that life stressors are associated with an increased risk mood disorders adulthood.This review examines emerging literature on relationship between stress, hypothalamic-pituitary-adrenal (HPA) axis function, and depression stress as important factor HPA dysregulation.The consistent findings...
Background: Treatment-resistant depression patients show both reduced glucocorticoid receptor function and a hyperactive hypothalamic-pituitary-adrenal axis. However, few studies have examined the role of mineralocorticoid receptor. This study aimed to evaluate functional activity system in regulating axis well-defined treatment-resistant patients. Material method: We recruited 24 subjects divided into: (a) depression; (b) healthy controls. evaluated: effect combined...
Abstract Purpose: To compare the hippocampal volumes in patients with bipolar disorder (BD) and healthy controls, obtained by applying different segmentation methods (manual, Freesurfer [FS], FSL). Materials Methods: The study included 27 BD 40 controls. T1‐weighted images sagittal plane were acquired on a 3 Tesla (T) MR scanner. Hippocampal volumetry was performed using one manual two automated (FS One‐way repeated analysis of variance applied to test differences three methods. evaluate...