A5061217611- Neurogenesis and neuroplasticity mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Adipose Tissue and Metabolism
- Tuberculosis Research and Epidemiology
- Infectious Diseases and Tuberculosis
- Muscle Physiology and Disorders
- Cholesterol and Lipid Metabolism
- MicroRNA in disease regulation
- Pneumocystis jirovecii pneumonia detection and treatment
- Helicobacter pylori-related gastroenterology studies
- Digestive system and related health
- Coordination Chemistry and Organometallics
- Eosinophilic Esophagitis
- Epigenetics and DNA Methylation
- Botulinum Toxin and Related Neurological Disorders
- Mitochondrial Function and Pathology
- Parkinson's Disease Mechanisms and Treatments
- RNA Research and Splicing
- Animal Genetics and Reproduction
- Immune Response and Inflammation
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Multiple Sclerosis Research Studies
- Ion channel regulation and function
- Inflammatory Bowel Disease
Institute of Molecular Biotechnology
2025
Austrian Academy of Sciences
2025
Vienna Biocenter
2025
University Hospital Regensburg
2021-2023
University of Gothenburg
2018-2020
Friedrich-Alexander-Universität Erlangen-Nürnberg
2020
Universitätsklinikum Erlangen
2020
University of Regensburg
2020
University Hospital of Zurich
2018-2019
University of Zurich
2017
Intestinal fibrosis and stenosis are common complications of Crohn's disease [CD], frequently requiring surgery. Anti-inflammatory strategies can only partially prevent fibrosis; hence, anti-fibrotic therapies remain an unmet clinical need. Oxysterols oxidised cholesterol derivatives with important roles in various biological processes. The enzyme 25-hydroxylase [CH25H] converts to 25-hydroxycholesterol [25-HC], which modulates immune responses oxidative stress. In human intestinal samples...
Aerobic exercise prevents age-dependent decline in cognition and hippocampal neurogenesis. The transcription factor peroxisome proliferator-activated receptor gamma co-activator 1-alpha (PGC-1α) mediates many of the exercise-induced benefits skeletal muscle, including release factors into circulation with neurotrophic effects. We use a transgenic mouse model muscle-specific overexpression PGC-1α to study contribution chronic muscle activation on effects neurogenesis aging. Young old wild...
Abstract Neuroinflammation and demyelination are hallmarks of several neurological disorders such as multiple sclerosis system atrophy. To better understand the underlying mechanisms de- regeneration in respective diseases, it is critical to identify factors modulating these processes. One candidate factor alpha-Synuclein (aSyn), which known be involved pathology various neurodegenerative diseases. Recently, we have shown that aSyn modulation peripheral immune responses during acute...
Abstract Physical exercise can improve age-dependent decline in cognition, which rodent is partly mediated by restoration of an neurogenesis. Exercise-inducible myokines the circulation present a link muscle-brain crosstalk. The transcription factor PGC-1α regulates release such with neurotrophic properties into circulation. We study how chronic muscular overexpression could contribute to exercise-induced effects on hippocampal neurogenesis and if this effect be enhanced running wheel...
Genome-wide association studies identified a single nucleotide polymorphism (SNP) downstream of the transcription factor Sox8, associated with an increased risk multiple sclerosis (MS). Sox8 is known to influence oligodendrocyte terminal differentiation and involved in myelin maintenance by mature oligodendrocytes. The possible link related SNP MS risk, along role physiology prompted us investigate its relevance during de- remyelination using cuprizone model. Sox8-/- mice wildtype...
Abstract Recently, oligodendrocytes (Ol) have been attributed potential immunomodulatory effects. Yet, the exact mode of interaction with pathogenic CNS infiltrating lymphocytes remains unclear. Here, we attempt to dissect mechanisms Ol modulation during neuroinflammation and characterize T cells. RNA expression analysis revealed an upregulation immune‐modulatory genes adhesion molecules (AMs), ICAM‐1 VCAM‐1, in when isolated from mice undergoing experimental autoimmune encephalomyelitis...
Abstract Intestinal fibrosis and stenosis are common complications of Crohn’s disease (CD), frequently requiring surgery. Anti-inflammatory strategies can only partially prevent fibrosis; hence, anti-fibrotic therapies remain an unmet clinical need. Oxysterols oxidized cholesterol derivatives, with important roles in various biological processes. The enzyme 25-hydroxylase (CH25H) converts to 25-hydroxycholesterol (25-HC), which modulates immune responses oxidative stress. In human intestinal...
Background: Long-term treatment of inflammatory bowel disease (IBD) remains an ongoing challenge and intestinal stenosis or fibrosis are common complications during the course Crohn's (CD). Anti-inflammatory strategies, such as anti-tumor necrosis factor (TNF) antibodies immunosuppressants, only partially effective in preventing surgery often does not provide a definite solution. Thus, anti-fibrotic therapy approaches still unmet clinical need. Oxysterols oxidized derivatives cholesterol...
Abstract Genome-wide association studies identified a single nucleotide polymorphism (SNP) downstream of the transcription factor Sox8, associated with an increased risk multiple sclerosis (MS). Sox8 is known to influence oligodendrocyte terminal differentiation and involved in myelin maintenance by mature oligodendrocytes. The possible link related SNP MS risk, along role physiology prompted us investigate its relevance during de- remyelination using cuprizone model. −/− mice wildtype...