About
Contact & Profiles
A5075260472
Research Areas
- Cardiovascular Function and Risk Factors
- Cardiac Fibrosis and Remodeling
- Muscle Physiology and Disorders
University of Ottawa
2022
Heart failure (HF) is a rising global cardiovascular epidemic driven by aging and chronic inflammation. As elderly populations continue to increase, precision treatments for age-related cardiac decline are urgently needed. Here we report that blood expression of IGFBP7 robustly increased in patients with HF an mouse model. In pressure overload model, Igfbp7 deficiency attenuated dysfunction reducing inflammatory injury, tissue fibrosis cellular senescence. promoted senescence stimulating...
10.1038/s44161-022-00181-y
article
EN
cc-by
Nature Cardiovascular Research
2022-12-22
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