A5054806120- Heart Failure Treatment and Management
- Cardiovascular Function and Risk Factors
- Cardiac electrophysiology and arrhythmias
- Genetic Associations and Epidemiology
- Chronic Disease Management Strategies
- ECG Monitoring and Analysis
- Cardiac pacing and defibrillation studies
- Atrial Fibrillation Management and Outcomes
- Heart rate and cardiovascular health
- Cardiac Arrhythmias and Treatments
- Genetics and Neurodevelopmental Disorders
- Receptor Mechanisms and Signaling
- Chronic Kidney Disease and Diabetes
- Cardiac Imaging and Diagnostics
- Advanced Causal Inference Techniques
- Electronic Health Records Systems
- Congenital heart defects research
- Ethics in Clinical Research
- Ion channel regulation and function
- Biomedical Text Mining and Ontologies
- Artificial Intelligence in Healthcare
- Genomics and Rare Diseases
- Cardiovascular Health and Disease Prevention
- Health Systems, Economic Evaluations, Quality of Life
- Medical Coding and Health Information
Servier (France)
2015-2024
Bayer (France)
2022-2024
Bayer (United States)
2024
Plateforme Technologique d'Innovation Biomédicale
2018-2023
Institut des Hautes Études Scientifiques
2015-2023
AG Medical (France)
2023
University of Catania
2021
AVL (France)
2021
Centre Hospitalier Saint-Nazaire
2021
Na Homolce Hospital
2020
Mendelian randomisation (MR) analysis is an important tool to elucidate the causal relevance of environmental and biological risk factors for disease. However, inference undermined if genetic variants used instrument a factor also influence alternative disease-pathways (horizontal pleiotropy). Here we report how 'no horizontal pleiotropy assumption' strengthened when proteins are interest. Proteins typically proximal effectors processes encoded in genome. Moreover, targets most medicines, so...
BackgroundMachine learning has been used to analyse heart failure subtypes, but not across large, distinct, population-based datasets, the whole spectrum of causes and presentations, or with clinical non-clinical validation by different machine methods. Using our published framework, we aimed discover subtypes validate them upon population representative data.MethodsIn this external, prognostic, genetic study analysed individuals aged 30 years older incident from two databases in UK...
Big data is central to new developments in global clinical science aiming improve the lives of patients. Technological advances have led routine use structured electronic healthcare records with potential address key gaps evidence. The covid-19 pandemic has demonstrated big and related analytics, but also important pitfalls. Verification, validation, privacy, as well social mandate undertake research are challenges. European Society Cardiology BigData@Heart consortium brought together a...
BackgroundSelective inhibitors of Kv1.5 channels are being developed for the treatment atrial fibrillation (AF).ObjectivesThe purpose this study was to investigate effects highly selective inhibitor XEN-D0103 on human action potentials (APs) at high excitation rates and assess safety.MethodsIntracellular APs (stimulation 1–5 Hz) were measured in right trabeculae from patients sinus rhythm (SR), chronic AF (cAF; >6 months duration), paroxysmal (pAF). The safety tolerability tested a...
Heart failure (HF) is a rising global cardiovascular epidemic driven by aging and chronic inflammation. As elderly populations continue to increase, precision treatments for age-related cardiac decline are urgently needed. Here we report that blood expression of IGFBP7 robustly increased in patients with HF an mouse model. In pressure overload model, Igfbp7 deficiency attenuated dysfunction reducing inflammatory injury, tissue fibrosis cellular senescence. promoted senescence stimulating...
Big data is central to new developments in global clinical science aiming improve the lives of patients. Technological advances have led routine use structured electronic healthcare records with potential address key gaps evidence. The covid-19 pandemic has demonstrated big and related analytics, but also important pitfalls. Verification, validation, privacy, as well social mandate undertake research are challenges. European Society Cardiology BigData@Heart consortium brought together a...
The effect of bilastine on cardiac repolarization was studied in 30 healthy participants during a multiple‐dose, triple‐dummy, crossover, thorough QT study that included 5 arms: placebo, active control (400 mg moxifloxacin), at therapeutic and supratherapeutic doses (20 100 once daily, respectively), 20 administered with ketoconazole 400 mg. Time‐matched, triplicate electrocardiograms (ECGs) were recorded 13 time points extracted predose 16 over 72 hours post day 4 dosing. Four QT/RR...
Background: The usefulness of adjudication by central end point committees (CECs) is poorly assessed in heart failure (HF) trials. We aimed to assess its impact on the outcome SHIFT trial (Systolic HF Treatment With If Inhibitor Ivabradine Trial). Methods: was a randomized placebo-controlled investigating effect ivabradine 6505 patients with reduced ejection fraction. Prespecified points, reported investigators (all cardiologists) using specific case report form pages, included all-cause and...
Aims In order to understand how sex differences impact the generalizability of randomized clinical trials (RCTs) in patients with heart failure (HF) and reduced ejection fraction (HFrEF), we sought compare characteristics outcomes between RCTs HF observational registries stratified by sex. Methods results Data from two five HFrEF were used create three subpopulations: one RCT population ( n = 16 917; 21.7% females), registry eligible for inclusion 26 104; 31.8% ineligible 20 810; 30.2%...
The global QT interval, emerging as a standard measurement provided by digital electrocardiographs, is defined the earliest QRS onset and latest T-wave offset that occur in any of leads. Differences between ECG measurements those from individual leads have implications for redefinition normal values, recognition disease, drug safety. This study sought to quantify differences intervals measured 12 superimposed with single lead complexes, examine separate effects on these differences,...
Antiarrhythmic drugs (AADs) for the treatment of atrial fibrillation (AF) are associated with limited efficacy and adverse effects. Inhibition current IKur, absent from ventricle, is expected to be antiarrhythmic, without cardiac effects, particularly ventricular pro-arrhythmic effects.A randomized clinical trial in symptomatic paroxysmal AF patients being considered ablation. The primary endpoint was burden (AFB) as measured by insertable continuous monitoring (ICM) devices. Screened had an...
Heart failure (HF) trials have stringent inclusion and exclusion criteria, but limited data exist regarding generalizability of trials. We compared patient characteristics outcomes between patients with HF reduced ejection fraction (HFrEF) in observational registries.Individual for 16 922 from five randomized clinical 46 914 two registries were included. The registry categorized into trial-eligible non-eligible groups using the most commonly used criteria. A total 26 104 (56%) fulfilled...
This study aims to investigate normal changes throughout aging of the heart in cardiac magnetic resonance (CMR) imaging healthy volunteers. While type 2 diabetes mellitus is a frequent finding elderly population, also influence this circumstance otherwise persons part our study.In prospective single-center trial, 75 subjects distinct age groups and 10 diabetics were enrolled. All underwent functional, flow sensitive, native T2- T1-mapping 1.5T CMR scanner.No differences right left...
This study compares the ability of 2 semiautomated methods with a fully automated method for QT measurement to minimize sample size required detect moxifloxacin effect and exclude placebo in thorough QT/QTc study. The 1 used global 12 leads, whereas other tangent on single lead raw complexes. Mean QTcF intervals were greater when measured electrocardiogram than complexes, but mean magnitudes ΔQTcF similar all methods. 3 detected statistically significant increase compared able 62...
Abstract Mendelian randomisation analysis has emerged as an important tool to elucidate the causal relevance of a range environmental and biological risk factors for human disease. However, inference on cause is undermined if genetic variants used instrument factor interest also associate with other traits that open alternative pathways disease (horizontal pleiotropy). We show how ‘no horizontal pleiotropy assumption’ in MR strengthened when proteins are interest. Proteins proximal effectors...
Background The effects of α and ß adrenergic receptor modulation on the risk developing heart failure (HF) remains uncertain due to a lack randomized controlled trials. This study aimed estimate receptors HF provide proof principle for genetic target validation studies in HF. Methods Genetic variants within cis regions encoding α1A, α2B, ß1, ß2 associated with blood pressure 757,601-participant genome-wide association (GWAS) were selected as instruments perform drug Mendelian randomization...