Thomas Leclerc

ORCID: 0000-0003-3829-3286
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About
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Research Areas
  • Burn Injury Management and Outcomes
  • Wound Healing and Treatments
  • Trauma and Emergency Care Studies
  • Disaster Response and Management
  • Cardiac Arrest and Resuscitation
  • Injury Epidemiology and Prevention
  • Cardiac, Anesthesia and Surgical Outcomes
  • Respiratory Support and Mechanisms
  • Mesenchymal stem cell research
  • Hemodynamic Monitoring and Therapy
  • Anesthesia and Sedative Agents
  • Airway Management and Intubation Techniques
  • Antifungal resistance and susceptibility
  • Sepsis Diagnosis and Treatment
  • Trauma, Hemostasis, Coagulopathy, Resuscitation
  • Ultrasound in Clinical Applications
  • Organ and Tissue Transplantation Research
  • Emergency and Acute Care Studies
  • Heme Oxygenase-1 and Carbon Monoxide
  • Electrospun Nanofibers in Biomedical Applications
  • Traumatic Brain Injury and Neurovascular Disturbances
  • Intensive Care Unit Cognitive Disorders
  • Nausea and vomiting management
  • Phonocardiography and Auscultation Techniques
  • Venomous Animal Envenomation and Studies

Service de Santé des Armées
2016-2024

Université Paris Cité
2018-2023

Institut de Psychiatrie et Neurosciences de Paris
2023

FHU Neurovasc
2023

Inserm
2023

Hôpital d'instruction des Armées Percy
2013-2023

Hôpital Necker-Enfants Malades
2023

Prince Medical (France)
2020-2023

Assistance Publique – Hôpitaux de Paris
2023

HIA du Val-de-Grâce à Paris
2009-2022

Health and logistical needs in emergencies have been well recognised. The last 7 years has witnessed improved professionalisation standardisation of care for disaster affected communities - led part by the World Organisation Emergency Medical Team (EMT) initiative. Mass casualty incidents (MCIs) resulting burn injuries present unique challenges. Burn management benefits from specialist skills, expert knowledge, timely availability resources. With MCIs occurring globally, wide variance...

10.1016/j.burns.2020.07.001 article EN cc-by-nc-nd Burns 2020-07-13

Lake Dziani Dzaha is a thalassohaline tropical crater lake located on the "Petite Terre" Island of Mayotte (Comoros archipelago, Western Indian Ocean). Stromatolites are actively growing in shallow waters shores. These stromatolites mainly composed aragonite with lesser proportions hydromagnesite, calcite, dolomite and phyllosilicates. They morphologically texturally diverse ranging from tabular covered by cauliflower-like crust to columnar ones smooth surface. High-throughput sequencing...

10.3389/fmicb.2018.00796 article EN cc-by Frontiers in Microbiology 2018-05-22

To provide recommendations to facilitate the management of severe thermal burns during acute phase in adults and children. A committee 20 experts was asked produce six fields burn management, namely, (1) assessment, admission specialised centres, telemedicine; (2) haemodynamic management; (3) airway smoke inhalation; (4) anaesthesia analgesia; (5) wound treatments; (6) other treatments. At start recommendation-formulation process, a formal conflict-of-interest policy developed enforced...

10.1016/j.accpm.2020.03.006 article EN cc-by Anaesthesia Critical Care & Pain Medicine 2020-03-09

The use of hydroxocobalamin has long been advocated for treating suspected cyanide poisoning after smoke inhalation. Intravenous however shown to cause oxalate nephropathy in a single-center study. impact on the risk acute kidney injury (AKI) and survival inhalation multicenter setting remains unexplored.We conducted retrospective study 21 intensive care units (ICUs) France. We included patients admitted an ICU between January 2011 December 2017. excluded discharged at home alive within 24 h...

10.1186/s13054-019-2706-0 article EN cc-by Critical Care 2019-12-01

Mesenchymal stem cell (MSC) therapy has recently been investigated as a potential treatment for cutaneous radiation burns. We tested the hypothesis that injection of local gingival fibroblasts (GFs) would promote healing burn lesions and compared results with those MSC transplantation. Human clinical- grade GFs or bone marrow-derived MSCs were intradermally injected into mice 21 days after leg irradiation. Immunostaining real-time PCR analysis used to assess effects each on extracellular...

10.1089/scd.2014.0486 article EN Stem Cells and Development 2015-01-13

Burn fluid resuscitation guidelines have not specifically addressed mass casualty with resource limited situations, except for oral rehydration burns below 40% total body surface area (TBSA). The World Health Organization Technical Working Group on Burns (TWGB) recommends an initial rate of 100 mL/kg/24 h, either orally or intravenously, beyond 20% TBSA burned. We aimed to compare this formula current guidelines.The TWGB was numerically compared 2-4 mL/kg/%TBSA adults and the Galveston...

10.1016/j.burns.2021.02.022 article EN cc-by Burns 2021-02-27

A European response plan to burn mass casualty incidents has been jointly developed by the Commission and Burn Association. Upon request for assistance an affected country, outlines a mechanism coordinated international assistance, aiming alleviate burden of care in country offer adequate specialized all patients who can benefit from it. To that aim, Assessment Teams are deployed assess triage patients. Their transportation priority recommendations used distribute outnumbering casualties...

10.1016/j.burns.2022.12.011 article EN cc-by Burns 2022-12-26

Objectives Life after severe burns is conditioned by the remaining sequelae. The pathophysiology and risk factors of Heterotopic Ossification (HO) are still poorly understood. aim this study was to determine: 1) incidence HO 2) associated with development, in a large retrospective study. Methods A case-control patients admitted intensive care unit Percy Hospital, Paris, from 1st January 2009 31st December 2013 then one three centres specialised rehabilitation burns. Multivariate analysis...

10.1371/journal.pone.0182303 article EN cc-by PLoS ONE 2017-08-04

Abstract Cultured epithelial autografts (CEAs) produced from a small, healthy skin biopsy represent lifesaving surgical technique in cases of full-thickness burn covering >50% total body surface area. CEAs also present numerous drawbacks, among them the use animal proteins and cells, high fragility keratinocyte sheets, immaturity dermal-epidermal junction, leading to heavy cosmetic functional sequelae. To overcome these weaknesses, we developed human plasma-based epidermal substitute...

10.5966/sctm.2014-0155 article EN cc-by-nc Stem Cells Translational Medicine 2015-04-06

Ventilation of Acute Respiratory Distress Syndrome (ARDS) is a challenge, and there definitely need for lack variations between delivered set tidal volume (Vt). We have assessed the ability ventilator T-birdVS02 LTV-1000 to deliver lung model with ARDS Vt at different simulated altitudes.We used decompression chamber mimic hypobaric environment range cabin altitudes 1,500, 2,500, 3,000 m (4,000, 6,670, 8,000 feet, respectively). Ventilators were tested realistic parameters. was 400 mL 250 in...

10.1097/ta.0b013e3181e8fd8b article EN Journal of Trauma and Acute Care Surgery 2010-08-28

We compared the subjective quality of pulmonary auscultation between 2 acoustic stethoscopes (Holtex Ideal® and Littmann Cardiology III®) an electronic stethoscope (Littmann 3200®) in operating room.A prospective double-blind randomized study with evaluation during mechanical ventilation was performed 100 patients. After each examination, listeners using a numeric scale (0-10) rated auscultation. Auscultation patients among multilevel mixed-effects linear regression random intercept...

10.1213/ane.0b013e31829ec0a5 article EN Anesthesia & Analgesia 2013-07-19
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