A5072162686- Heterotopic Ossification and Related Conditions
- Botulinum Toxin and Related Neurological Disorders
- Cervical and Thoracic Myelopathy
- Spine and Intervertebral Disc Pathology
- Stroke Rehabilitation and Recovery
- Cerebral Palsy and Movement Disorders
- Orthopaedic implants and arthroplasty
- Orthopedic Surgery and Rehabilitation
- Health, Medicine and Society
- Peripheral Nerve Disorders
- Nerve Injury and Rehabilitation
- Total Knee Arthroplasty Outcomes
- Medical Imaging and Pathology Studies
- Musculoskeletal pain and rehabilitation
- Neurogenetic and Muscular Disorders Research
- Sports injuries and prevention
- Hip disorders and treatments
- Diabetic Foot Ulcer Assessment and Management
- Hereditary Neurological Disorders
- Viral Infections and Immunology Research
- Orthopedic Infections and Treatments
- Neurological disorders and treatments
- Traumatic Brain Injury Research
- Shoulder Injury and Treatment
- Genetic Syndromes and Imprinting
Inserm
2016-2025
Assistance Publique – Hôpitaux de Paris
2015-2025
Université de Versailles Saint-Quentin-en-Yvelines
2016-2025
Hôpital Raymond-Poincaré
2016-2025
Université Paris-Saclay
2021-2025
Handicap neuromusculaire : Physiopathologie, Biothérapie et Pharmacologie appliquées
2016-2024
Queensland University of Technology
2021
Centre d'Investigation Clinique - Innovation Technologique
2017-2019
Mater Research
2015-2019
The University of Queensland
2015-2019
Neurological heterotopic ossification (NHO) is the abnormal formation of bone in soft tissues as a consequence spinal cord or traumatic brain injury. NHO causes pain, ankyloses, vascular and nerve compression delays rehabilitation this high-morbidity patient group. The pathological mechanisms leading to remain unknown consequently there are no therapeutic options prevent reduce NHO. Genetically modified mouse models rare genetic forms (HO) exist, but their relevance questionable....
Neurogenic heterotopic ossification (NHO) is the formation of ectopic bone generally in muscles surrounding joints following spinal cord or brain injury. We investigated mechanisms NHO 64 patients and a mouse model injury–induced NHO. show that marrow from human NHOs contains hematopoietic stem cell (HSC) niches, which mesenchymal stromal cells (MSCs) endothelial provide an environment supporting HSC maintenance, proliferation, differentiation. The transcriptomic signature MSCs shows...
Heterotopic ossification (HO) is a frequent complication after central nervous system (CNS) damage but has seldom been studied. We aimed to investigate features of HO for the first time in large sample and rate early recurrence terms surgery.We retrospectively analyzed data from an anonymous prospective survey patients undergoing surgery between May 1993 November 2009 our institution troublesome related acquired neurological disease. Demographic characteristics etiologies were recorded. For...
Heterotopic ossification (HO) of the hip after injury to central nervous system can lead joint ankylosis. Surgery is usually delayed avoid recurrence, even if functional status affected. We report a consecutive series patients with HO who required surgery in single, specialised tertiary referral unit. As was usual practice, they all underwent CT determine location and evaluate density femoral head articular surface. The outcome correlated pre-, peri- post-operative findings. In all, 183 hips...
Background. After a severe traumatic brain injury (TBI), some patients are discharged home without rehabilitation, although rehabilitation is assumed to improve outcome. Objective. To assess factors that predict referral following acute care. This study part of larger inception cohort assessing the care network in Parisian area (France). Methods. Between July 2005 and April 2007, 504 adults with TBI (Glasgow Coma Scale score ≤8) were prospectively recruited by mobile emergency services....
Electrophysiological or ultrasound guidance can facilitate botulinum toxin A (BoNt-A) injection accuracy, but clinical landmarks and palpation are often used for superficial muscles. We evaluated the accuracy of manual needle placement in gastrocnemius muscles (GC) guided only by anatomical palpation.Bilateral limbs from 30 cadavers were to evaluate ink into GC. One anatomist one orthopedic surgeon verified postinjection calf muscle dissection. Injection was considered a failure if not...
There is an outstanding increased demand for recommendations in the rehabilitation field. Over 600 recommendation articles have been published last decade, primarily by groups of authors based on unclear criteria and only a few learned societies standardized methods. In 2007, French Society Physical Rehabilitation Medicine (SOFMER) methodology to establish physical medicine (PRM). This framework, which served publish 22 sets management recommendations, must be reworked meet new international...
Neurogenic heterotopic ossifications (NHO) are very incapacitating complications of traumatic brain and spinal cord injuries (SCI) which manifest as abnormal bone tissue formation periarticular muscles. NHO debilitating they cause pain, partial or total joint ankylosis vascular nerve compression. pathogenesis is unknown the only effective treatment remains surgical resection, however once resected, can re-occur. To further understand pathogenesis, we developed first animal model following...
The aim of the study was to measure prevalence traumatic brain injury (TBI)-related disability and health status in general population.The French National Survey, conducted households institutions, assessed 33,896 adults. Data included sequelae from TBI, impairments, current conditions, uses services. Analyses, adjusted for age sex, compared subjects who declared TBI (n = 479) with remaining survey population 33,287). Use weighting factors ensured that results were representative national...
Background: Contracture of the wrist and extrinsic finger flexor pronator muscles is a common consequence central nervous system disorders. The proximal release was first described by Page Scaglietti for Volkmann contracture. aim present study to assess amount increase in extension improvements global hand function that can be expected following this lengthening procedure patients with Method: A single-center retrospective review lesions contractures forearm muscles, causing aesthetic,...
The timing of surgery with regard to recurrence risk after neurologic heterotopic ossification (HO) excision is still debated. This study investigated the association between HO in traumatic brain injury (TBI) patients and (1) operative delay (2) degree sequelae (Garland status). A case-control was performed. Patients who developed troublesome requiring TBI (case, n = 16) or without (control, 64) were retrospectively included. Other matching criteria sex age at time (± 4 years). median for...
The preoperative Heterotopic Ossification (HO) extent is usually one of the main used criteria to predict recurrence before excision. Brooker et al built a radiologic scale assess this pre operative around hip. aim study investigate relationship between risk after hip HO excision in Traumatic Brain Injury (TBI) and Spinal Cord (SCI) patients HO.A case control including TBI or SCI following surgery for troublesome with (case, n = 19) without (control, 76) recurrence. Matching were: sex,...
ABSTRACT Neurogenic heterotopic ossifications (NHOs) form in periarticular muscles after severe spinal cord (SCI) and traumatic brain injuries. The pathogenesis of NHO is poorly understood with no effective preventive treatment. only curative treatment remains surgical resection pathological NHOs. In a mouse model SCI-induced that involves transection the combined muscle injury, differential gene expression analysis revealed genes involved inflammation such as interleukin-1β (IL-1β) were...