A5102753083- Hemodynamic Monitoring and Therapy
- Sepsis Diagnosis and Treatment
- Cardiac, Anesthesia and Surgical Outcomes
- Traumatic Brain Injury and Neurovascular Disturbances
- Cardiovascular Health and Disease Prevention
- Intensive Care Unit Cognitive Disorders
- Cardiac Arrest and Resuscitation
- Streptococcal Infections and Treatments
- Acute Kidney Injury Research
- Otolaryngology and Infectious Diseases
- Renal function and acid-base balance
- Respiratory Support and Mechanisms
- Non-Invasive Vital Sign Monitoring
- Anesthesia and Sedative Agents
- Heart Rate Variability and Autonomic Control
- Blood Pressure and Hypertension Studies
- Trauma and Emergency Care Studies
- Optical Imaging and Spectroscopy Techniques
- Neurosurgical Procedures and Complications
- Acute Ischemic Stroke Management
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Nitric Oxide and Endothelin Effects
- Nosocomial Infections in ICU
- Traumatic Brain Injury Research
- Cerebral Venous Sinus Thrombosis
Hôpital Lariboisière
2014-2025
Assistance Publique – Hôpitaux de Paris
2013-2025
Université Paris Cité
2015-2025
Inserm
2014-2025
Sorbonne Paris Cité
2016-2025
Délégation Paris 7
2015-2023
Laboratoire Vision Action Cognition
2023
Hôpital Fernand-Widal
2005-2021
Institut national de recherche en informatique et en automatique
2019
Intensive Care Society
2019
Background and Purpose— There is no effective medical treatment of malignant middle cerebral artery (MCA) infarction. The purpose this clinical trial was to assess the efficacy early decompressive craniectomy in patients with MCA Methods— We conducted France a multicenter, randomized involving between 18 55 years age infarction compare functional outcomes or without craniectomy. A sequential, single-blind, triangular design used rate development moderate disability (modified Rankin scale...
The role of systemic hemodynamics in the pathogenesis septic acute kidney injury (AKI) has received little attention. purpose this study was to investigate association between and new or persistent AKI severe sepsis.A retrospective 2006 2010 performed a surgical ICU teaching hospital. defined as development (new AKI) during five days following admission based on Acute Kidney Injury Network (AKIN) criteria. We studied hemodynamic targets within 24 hours AKI: central venous pressure (CVP),...
Objective: The impact of continuous venovenous hemofiltration on sepsis-induced multiple organ failure severity is controversial. We sought to assess the effect early application degree dysfunction and plasma cytokine levels in patients with severe sepsis or septic shock. Design: Prospective, randomized, open, multicenter study setting, 12 French intensive care units. Patients: A total 80 were enrolled within 24 hours development first related a new insult. Interventions: Patients randomized...
To prospectively evaluate the efficacy and safety of emergency selective arterial embolization in management intractable primary postpartum hemorrhage.Twenty-seven consecutively seen women with life-threatening hemorrhage underwent uterine embolization. In all cases, hemostatic was performed because that could not be controlled vaginal packing administration uterotonic drugs. The mean hemoglobin level before 7.48 g/dL +/- 2.39 (74.8 g/L 23.9) (1 standard deviation). Hysterectomy two patients...
Measurement of cardiac output using thermodilution technique in mechanically ventilated patients is associated with significant morbidity. The goal the present study was to assess validity measurement transesophageal Doppler critically ill patients. Forty-six from three different intensive care units underwent 136 paired measurements (COTH) and (COTED). In addition, simultaneous suprasternal indirect calorimetry (Fick principle) were used measure 26 one center. A good correlation found...
Abstract Introduction Septic shock is one of the most frequent causes admission to intensive care unit (ICU) and associated with a poor prognosis. Early late death in septic should be distinguished because they may involve different underlying mechanisms. In various conditions, neutrophil-to-lymphocyte count ratio (NLCR) has been described as an easily measurable parameter express injury severity. present study, we investigated whether timing was related particular NLCR. Methods We conducted...
Abstract Introduction The risk factors associated with poor outcome in generalized peritonitis are still debated. Our aim was to analyze clinical and bacteriological the occurrence of shock mortality patients secondary peritonitis. Methods This a prospective observational study involving 180 consecutive (community-acquired postoperative) at single center. We recorded peri-operative septic 30-day survival rate analyzed their associations characteristics (age, gender, SAPS II, liver cirrhosis,...
Objectives: To assess outcome and predicting factors 1 year after a severe traumatic brain injury (TBI).Methods: Multi-centre prospective inception cohort study of patients aged 15 or older with TBI in the Parisian area, France. Data were collected prospectively starting day injury. One-year evaluation included relatives-rating Dysexecutive Questionnaire (DEX-R), Glasgow Outcome Scale–Extended (GOSE) employment. Univariate multivariate tests computed.Results: Among 257 survivors, 134 (mean...
ABSTRACT PCR assays for the diagnosis of systemic candidiasis can be performed either on serum or whole blood, but results obtained with two kinds samples have never been formally compared. Thus we designed a nested assay in which five specific inner pairs primers were used to amplify targets rRNA genes Candida albicans , C. tropicalis parapsilosis krusei and glabrata . In vitro, lower limit detection each was 1 fg purified DNA from corresponding species. rabbits candidemia 120 minutes’...
High B-type natriuretic peptide (BNP) levels are reported in the context of septic shock. We hypothesized that high BNP might be related to an alteration clearance pathway, namely neutral endopeptidase (NEP) 24.11. NEP 24.11 activity was measured shock and cardiogenic patients. further evaluated whether baseline plasma can predict fluid responsiveness still released despite initial levels, response overloading.Prospective observational study. Patients severe sepsis (S) or (SS) needing a...
Abstract Introduction The occurrence of cardiac dysfunction is common after subarachnoid hemorrhage (SAH) and was hypothesized to be related the release endogenous catecholamines. aim this prospective study evaluate relationship between catecholamine at onset during first week SAH. Methods Forty consecutive patients admitted for acute SAH without known heart disease were included. Catecholamine plasma concentrations transthoracic echocardiography (TTE) documented on admission, day 1 (D1), 7...
Introduction During general anesthesia, arterial hypotension is frequent and may be an important contributor to perioperative morbidity. We assessed the effect of a 5 μg bolus Norepinephrine ( NA ) when compared with 50 Phenylephrine PE administered treat during maintenance on MAP , derived cardiac output stiffness parameters. Methods Patients scheduled for neurosurgical procedure under anesthesia were prospectively included. Monitoring included invasive blood pressure, esophageal Doppler,...
Background: Emphasis in therapy of human septic shock is shifting towards reliable end points and predictors survival. Rationale to study whether the evolution cardiovascular reactivity view administered doses norepinephrine an early predictor in-hospital survival determine optimal threshold its consequences on renal function. Methods: Observational a prospective cohort patients shock, hospitalized intensive care unit at least 24 hours before requiring norepinephrine. Excluded were <72...
Abstract Introduction Our aim was to describe inflammatory cytokines response in the peritoneum and plasma of patients with peritonitis. We also tested hypothesis that scenarios associated worse outcome would result different cytokine release patterns. Therefore, we compared responses according occurrence septic shock, mortality, type peritonitis peritoneal microbiology. Methods Peritoneal (interleukin (IL) 1, tumor necrosis factor α (TNFα), IL-6, IL-10, interferon γ (IFNγ)) were measured 66...
Severity of cerebral venous thrombosis (CVT) may require the transfer to intensive care unit (ICU). This report described context for CVT ICU, strategy and outcome after 1 year.Monocentric cohort 41 consecutive admitted in a French ICU tertiary hospital (National Referent Center CVT). Data collected are as follows: demographic data, clinical course, incidence craniectomy and/or endovascular procedures 3 12 months.47 years old (IQ 26-53), with 73.2 % were female, having SAPS II (32-45), GCS 7...
To assess determinants of loss to follow-up (FU) at 2 time points an inception traumatic brain injury (TBI) cohort.The PariS-TBI study consecutively included 504 adults with severe TBI on the accident scene (76% male, mean age 42 years, Glasgow Coma Scale 5). No exclusion criteria were used.Loss FU 1 and 4 years was defined among survivors as having no outcome data other than survival status.Among 257 1-year survivors, 118 (47%) lost year 98 (40%) years. Main reasons for impossibility...