A5037159857- Cardiovascular Function and Risk Factors
- Metabolomics and Mass Spectrometry Studies
- Cardiac Imaging and Diagnostics
- Adipose Tissue and Metabolism
- Muscle metabolism and nutrition
- Genetic Associations and Epidemiology
- Cardiac Valve Diseases and Treatments
- Cardiovascular and exercise physiology
- Advanced Proteomics Techniques and Applications
- Pulmonary Hypertension Research and Treatments
- Diet and metabolism studies
- Heart Failure Treatment and Management
- Nutritional Studies and Diet
- Exercise and Physiological Responses
- Advanced MRI Techniques and Applications
- Mechanical Circulatory Support Devices
- Cardiac Structural Anomalies and Repair
- Coronary Interventions and Diagnostics
- Genetics and Physical Performance
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiovascular Health and Risk Factors
- Health, Environment, Cognitive Aging
- Lipoproteins and Cardiovascular Health
- Pancreatic function and diabetes
- Metabolism, Diabetes, and Cancer
Stanford University
2021-2025
Bassett Medical Center
2013-2024
Bassett Healthcare Network
2024
Icahn School of Medicine at Mount Sinai
2017-2024
Stanford Medicine
2024
Beth Israel Deaconess Medical Center
2018-2023
Rush University Medical Center
2022-2023
Cornell University
2023
Harvard University
2020-2022
Cardiovascular Institute Hospital
2021
Background— Heart failure with preserved ejection fraction (HFpEF) is a heterogeneous clinical syndrome in need of improved phenotypic classification. We sought to evaluate whether unbiased clustering analysis using dense data (phenomapping) could identify phenotypically distinct HFpEF categories. Methods and Results— prospectively studied 397 patients performed detailed clinical, laboratory, ECG, echocardiographic phenotyping the study participants. used several statistical learning...
High-throughput proteomic profiling using antibody or aptamer-based affinity reagents is used increasingly in human studies. However, direct analyses to address the relative strengths and weaknesses of these platforms are lacking. We assessed findings from SomaScan1.3K ( N = 1301 reagents), SomaScan5K platform 4979 Olink Explore 1472 reagents) techniques 568 adults Jackson Heart Study 219 participants HERITAGE Family across four performance domains: precision, accuracy, analytic breadth,...
Heart failure with preserved ejection fraction (HFpEF) is a heterogeneous syndrome associated multiple pathophysiologic abnormalities, including left ventricular (LV) diastolic dysfunction, longitudinal LV systolic abnormal ventricular-arterial coupling, pulmonary hypertension, and right (RV) remodeling/dysfunction. However, the relative prognostic significance of each these abnormalities in HFpEF unknown.We prospectively studied 419 patients using echocardiography sphygmomanometry to assess...
Regular exercise leads to widespread salutary effects, and there is increasing recognition that exercise-stimulated circulating proteins can impart health benefits. Despite this, limited data exist regarding the plasma proteomic changes occur in response regular exercise. Here, we perform large-scale profiling 654 healthy human study participants before after a supervised, 20-week endurance training intervention. We identify hundreds of are modulated, many which known be secreted. highlight...
Background— Albuminuria is a marker of endothelial dysfunction and has been associated with adverse cardiovascular outcomes. The reasons for this association are unclear but may be attributable to the relationship between intrinsic myocardial dysfunction. Methods Results— In Hypertension Genetic Epidemiology Network (HyperGEN) Study, population- family-based study hypertension, we examined urine albumin-to-creatinine ratio (UACR) cardiac mechanics (n=1894, all whom had normal left...
Background: Heart failure (HF) is a heterogeneous disease characterized by significant metabolic disturbances; however, the breadth of dysfunction before onset overt not well understood. The purpose this study was to determine association circulating metabolites with incident HF uncover novel pathways disease. Methods: We performed targeted plasma metabolomic profiling in deeply phenotyped group Black adults from JHS (Jackson Study; n=2199). related associated established etiological...
Abstract Integrating genetic information with metabolomics has provided new insights into genes affecting human metabolism. However, gene-metabolite integration been primarily studied in individuals of European Ancestry, limiting the opportunity to leverage genomic diversity for discovery. In addition, these analyses have principally involved known metabolites, majority profiled peaks left unannotated. Here, we perform a whole genome association study 2,291 metabolite (known and unknown...
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Recent advances in proteomic technologies have made high-throughput profiling of low-abundance proteins large epidemiological cohorts increasingly feasible. We investigated whether aptamer-based could identify biomarkers associated with future development type 2 diabetes (T2DM) beyond known risk factors. identified dozens markers highly significant associations T2DM across longitudinal (n = 2839) followed for up to 16 years. leveraged proteomic, metabolomic, genetic, and clinical data from...
Plasma proteins are critical mediators of cardiovascular processes and the targets many drugs. Previous efforts to characterize genetic architecture plasma proteome have been limited by a focus on individuals European descent leveraged genotyping arrays imputation. Here we describe whole genome sequence analysis in with greater African ancestry, increasing our power identify novel determinants.
Measures from affinity-proteomics platforms often correlate poorly, challenging interpretation of protein associations with genetic variants (pQTL) and phenotypes. Here, we examined 2,157 proteins measured on both SomaScan 7k Olink Explore 3072 across 1,930 participants similarity to European, African, East Asian, Admixed American ancestry references. Inter-platform correlation coefficients for these followed a bimodal distribution (median r=0.30). Protein measures were associated (pQTLs),...
<h3>Importance</h3> African American individuals have disproportionate rates of coronary heart disease (CHD) but lower levels artery calcium (CAC), a marker subclinical CHD, than non-Hispanic White individuals. may distinct metabolite profiles associated with incident CHD risk compared individuals, and examination these differences could highlight important processes that differ between them. <h3>Objectives</h3> To identify novel biomarkers CAC among to replicate findings in multiethnic...
Significance All existing blood biomarkers of kidney function such as creatinine and cystatin C undergo renal clearance are thus inversely correlated with estimated glomerular filtrate rate (eGFR). Using a proteomic approach, we highlight the release testican-2 among individuals undergoing invasive catheterization show that higher levels associated eGFR slower subsequent decline in two large racially diverse cohorts. In conjunction microscopy single-cell RNA sequencing human samples, these...
The presence of a renin-angiotensin system in the central nervous (CNS) has been demonstrated by several investigators, but little is known regarding origin its components. In this study we have compared immunological and physical-chemical nature angiotensinogen plasma cerebrospinal fluid (CSF) human subjects explored whether differences are present CSF concentrations normal hypertensive subjects. No significant was observed with respect to molecular weight (65-70,000) electrophoretic...