A5001619673- Acute Myocardial Infarction Research
- Coronary Interventions and Diagnostics
- Cardiac Imaging and Diagnostics
- Antiplatelet Therapy and Cardiovascular Diseases
- Mechanical Circulatory Support Devices
- Cardiac Arrest and Resuscitation
- Venous Thromboembolism Diagnosis and Management
- Atherosclerosis and Cardiovascular Diseases
- Cardiac Structural Anomalies and Repair
- Transplantation: Methods and Outcomes
- Blood Coagulation and Thrombosis Mechanisms
- Cerebrovascular and Carotid Artery Diseases
- Protease and Inhibitor Mechanisms
- COVID-19 Clinical Research Studies
- Cell Adhesion Molecules Research
- Heart Failure Treatment and Management
- Adipokines, Inflammation, and Metabolic Diseases
- Cardiac, Anesthesia and Surgical Outcomes
- Ultrasound in Clinical Applications
- DNA and Nucleic Acid Chemistry
- Pain Management and Treatment
- Atrial Fibrillation Management and Outcomes
- Advanced biosensing and bioanalysis techniques
- Vascular Procedures and Complications
- Traumatic Brain Injury Research
Columbia University Irving Medical Center
2016-2025
Texas Health Dallas
2015-2025
New York Hospital Queens
2014-2024
NewYork–Presbyterian Hospital
2014-2024
Columbia University
2010-2024
Cardiovascular Research Foundation
2012-2024
Presbyterian Hospital
2015-2021
New York University
2018
University of California, Los Angeles
2013
University of Pennsylvania
2013
Elevated levels of homocysteine are associated with an increased risk atherosclerosis and thrombosis. The reactivity the sulfhydryl group has been implicated in molecular mechanisms underlying this risk. There is also increasingly compelling evidence that thiols react presence nitric oxide (NO) endothelium-derived relaxing factor (EDRF) to form S-nitrosothiols, compounds potent vasodilatory antiplatelet effects. We, therefore, hypothesized S-nitrosation would confer these beneficial...
Abstract Background Nearly 30,000 patients with coronavirus disease-2019 (COVID-19) have been hospitalized in New York City as of April 14 th , 2020. Data on the epidemiology, clinical course, and outcomes critically ill COVID-19 this setting are needed. Methods We prospectively collected clinical, biomarker, treatment data adults laboratory-confirmed-COVID-19 admitted to two hospitals northern Manhattan between March 2 nd 1 st The primary outcome was in-hospital mortality. Secondary...
[Figure: see text].
Rapamycin is a potent inhibitor of smooth muscle cell (SMC) proliferation and migration. Rapamycin-mediated inhibition SMC associated with upregulation the cyclin-dependent kinase p27(Kip1). Previously, we showed that mixed embryonic fibroblasts obtained from p27(Kip1)(-/-) mice were relatively rapamycin-resistant, suggesting p27(Kip1) plays an integral role in modulating antiproliferative effects rapamycin. We hypothesized antimigratory effect rapamycin may also be mediated by...
Inflammatory biomarkers, including lipoprotein-associated phospholipase A2 (Lp-PLA2), myeloperoxidase (MPO), and high-sensitivity C-reactive protein (hsCRP) are associated with ischemic stroke risk. White matter hyperintensities (WMH) seen on brain MRI scans vascular risk factors an increased of incident stroke, but their relation to inflammatory biomarkers is unclear.The Northern Manhattan Study includes a stroke-free community-based sample Hispanic, black, white participants quantitative...
Background— Left ventricular (LV) mass is an important predictor of heart failure and cardiovascular mortality, yet determinants LV are incompletely understood. Pulmonary hyperinflation in chronic obstructive pulmonary disease (COPD) may contribute to changes intrathoracic pressure that increase wall stress. We therefore hypothesized residual lung volume COPD would be associated with greater mass. Methods Results— The Multi-Ethnic Study Atherosclerosis (MESA) recruited smokers 50 79 years...
Background— The relationship between white blood cell count (WBCc) and mortality in patients with ST-segment–elevation acute myocardial infarction treated percutaneous coronary intervention is poorly understood. Furthermore, whether there a WBCc risk of noncardiac bleeding after unknown. Methods Results— baseline was available 3193 3345 (95.5%) who underwent the Harmonizing Outcome With Revascularization Stent Acute Myocardial Infarction (HORIZONS-AMI) trial. In propensity-adjusted...
<b><i>Background:</i></b> Interleukin 6 (IL-6) is an inflammatory cytokine that has been associated with vascular disease and cognitive impairment, but few studies have examined these relationships in population-based include Hispanic Black people who often a greater prevalence of risk factors are at elevated dementia than Whites. We relative elevations plasma IL-6 concentrations relation to decline stroke-free racially/ethnically diverse community-based sample from...
Although SPECT myocardial perfusion imaging (MPI) provides valuable information about patients with chest pain, there is growing concern regarding its radiation burden and lengthy duration. New high-efficiency (HE) cameras stress-first protocols both offer the potential to markedly reduce radiation. No previous study has assessed outcomes doses of undergoing MPI on an HE-SPECT camera using ultra-low-dose protocol.One hundred presenting emergency department pain who were candidates for...
Background Cardiovascular involvement in coronavirus disease 2019 (COVID‐19) is common and leads to worsened mortality. Diagnostic cardiovascular studies may be helpful for resource appropriation identifying patients at increased risk death. Methods Results We analyzed 887 (aged 64±17 years) admitted with COVID‐19 from March 1 April 3, 2020 New York City 12 lead electrocardiography within 2 days of diagnosis. Demographics, comorbidities, laboratory testing, including high sensitivity cardiac...