A5025814240- Cardiac Arrhythmias and Treatments
- Cardiac electrophysiology and arrhythmias
- Cardiac pacing and defibrillation studies
- Atrial Fibrillation Management and Outcomes
- ECG Monitoring and Analysis
- Cardiac Structural Anomalies and Repair
- Mechanical Circulatory Support Devices
- Cardiovascular Function and Risk Factors
- Cardiac Arrest and Resuscitation
- Cardiac Imaging and Diagnostics
- Heart Rate Variability and Autonomic Control
- Transplantation: Methods and Outcomes
- COVID-19 Clinical Research Studies
- Cardiovascular Effects of Exercise
- Cardiac Valve Diseases and Treatments
- Viral Infections and Immunology Research
- Cardiovascular Syncope and Autonomic Disorders
- Ion channel regulation and function
- Heart Failure Treatment and Management
- Congenital Heart Disease Studies
- Non-Invasive Vital Sign Monitoring
- Advanced MRI Techniques and Applications
- Amyloidosis: Diagnosis, Treatment, Outcomes
- SARS-CoV-2 and COVID-19 Research
- Cardiac Ischemia and Reperfusion
Columbia University
2016-2025
Columbia University Irving Medical Center
2015-2024
NewYork–Presbyterian Hospital
2003-2023
New York Hospital Queens
2009-2023
Texas Health Dallas
2007-2021
Royal College of Physicians
2016-2021
Columbia College
2021
National Institute of Nursing Research
2020
Cornell University
2020
Cleveland Clinic
2009-2018
Although electrical alternans (alternating amplitude from beat to on the electrocardiogram) has been associated with ventricular arrhythmias in many clinical settings, its physiologic importance and prognostic implications remain unknown.To test hypothesis that is a marker of vulnerability arrhythmias, we developed technique detect subtle alternation morphologic features electrocardiogram (which would not be detectable by visual inspection electrocardiogram). In group 83 patients referred...
We performed electrophysiologic studies in 31 survivors of out-of-hospital cardiac arrest not associated with acute myocardial infarction. At the time resuscitation, eight patients had sustained ventricular tachycardia and 23 fibrillation. Programmed right stimulation later revealed electrically inducible arrhythmias 25 (81 per cent). Complete suppression was achieved antiarrhythmic therapy 19 these patients. None whom arrhythmia suppressed before discharge has died suddenly or a symptomatic...
We examined the role of electrophysiologic testing in prediction long-term outcome 166 survivors out-of-hospital cardiac arrest not associated with acute myocardial infarction. Ventricular arrhythmias were inducible 131 patients (79 percent) at base line and suppressed by antiarrhythmic drugs or surgery (or both) 91 127 (72 percent). During a median follow-up period 21 months, recurred 29 patients: 11(12 whom had been (including 5 treatment discontinued), 12 (33 36 persisted, 6 (17 35 could...
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SUDDEN cardiac death accounts for approximately two thirds of the 600,000 annual deaths that are attributable to disease in United States. Most these instantaneous, occurring within seconds or minutes, and where documented, terminal event has most cases been a ventricular tachyarrhythmia.1 2 3 4 Earlier studies have documented high rate recurrence fibrillation sudden patients with tachyarrhythmia regardless empirical antiarrhythmic drug therapy.2 , 5 6 In fact, between 30 60 per cent who...
BACKGROUND Recurrent sustained ventricular tachycardia (VT) is not responsive to antiarrhythmic drugs in the majority of patients, who therefore need therapy with nonpharmacological methods. We evaluated prospectively feasibility, safety, and efficacy transcatheter radiofrequency (RF) ablation VT 21 selected patients ischemic heart disease VT. METHODS AND RESULTS Twenty-one recurrent, drug-refractory documented by 12-lead ECG were had sufficient hemodynamic tolerance undergo mapping....
Survivors of out-of-hospital cardiac arrest not associated with acute myocardial infarction are at high risk for recurrent and sudden death. The impact the implantable cardioverter-defibrillator on long-term prognosis in these patients is uncertain.Three hundred thirty-one survivors (age, 56 +/- 13.7 years) underwent electrophysiologically guided therapy. Implantable defibrillators were placed 150 (45.3%), 181 (54.7%) received pharmacological and/or surgical therapy alone. Left ventricular...
Amiodarone was administered to 80 patients with recurrent cardiac tachyarrhythmias previously resistant drug treatment. Forty nine were treated for ventricular tachycardia or fibrillation and 31 supra-ventricular arrhythmias. The mean (range six days 51 months), permitting a total of 100 patient years observation. Adverse reactions observed in 69 patients. Severe side effects encountered 13: four developed interstitial pneumonitis, incessant tachycardia, three taking amiodarone digoxin...
Many patients undergoing transcatheter aortic valve implantation (TAVI) have a pre-existing, permanent pacemaker (PPM) or receive one as consequence of the procedure. We hypothesised that chronic pacing may adverse effects on TAVI outcomes.Four groups in Placement Aortic Transcatheter Valves (PARTNER) trial and registries were compared: prior PPM (n=586), new (n=173), no (n=1612), left bundle branch block (LBBB)/no (n=160). At 1 year, PPM, LBBB/no had higher all-cause mortality than (27.4%,...
Background— This study sought to evaluate the impact of atrial fibrillation (AF) on clinical outcomes in patients undergoing transcatheter aortic valve replacement. Methods and Results— Data were evaluated 1879 with baseline discharge ECGs who underwent replacement Placement AoRTic TraNscathetER Valve (PARTNER) trial. A total 1262 manifested sinus rhythm (SR) at baseline/SR discharge, 113 SR baseline/AF 470 AF discharge. Patients converted from by had highest rates all-cause mortality 30...
Abstract Objective This study evaluated the impact of daily ECG (electrocardiogram) self‐recordings on time to documented recurrent atrial fibrillation (AF) or flutter (AFL) and treatment arrhythmia in patients undergoing catheter radiofrequency ablation (RFA) direct current cardioversion (DCCV) for AF/AFL. Background AF recurrence rates after RFA DCCV are 20% 45% 60% 80%, respectively. Randomized trials comparing mobile devices standard care have not been performed an AF/AFL population...
Background This study examines the limitations and complex management problems associated with use of tiered-therapy, implantable cardioverter-defibrillators (ICDs). Methods Results The group comprises first 154 patients undergoing implantation tiered-therapy ICDs at our institution. Pulse generators from three different manufacturers were used. In 39 patients, a complete nonthoracotomy lead system was perioperative mortality 1.3%. Of these 37% experienced late postoperative problems....