A5103220177- Oral microbiology and periodontitis research
- Oral Health Pathology and Treatment
- Salivary Gland Disorders and Functions
- Immunodeficiency and Autoimmune Disorders
- Immune Response and Inflammation
- Complement system in diseases
- Bone and Dental Protein Studies
- Protease and Inhibitor Mechanisms
- interferon and immune responses
- Neonatal and Maternal Infections
- Pediatric health and respiratory diseases
- Drug-Induced Adverse Reactions
- Endodontics and Root Canal Treatments
- Toxin Mechanisms and Immunotoxins
- NF-κB Signaling Pathways
- Oral and gingival health research
- vaccines and immunoinformatics approaches
- Bone Metabolism and Diseases
- Streptococcal Infections and Treatments
University of Turku
1993-2020
Interleukin (IL)-23-induced T helper (Th) 17 pathway is involved in the pathogenesis of periodontal disease. This study's aim to determine levels IL-1β, IL-17A, IL-23, and lipopolysaccharide (LPS) saliva, examine whether their salivary concentrations are associated with health status.Saliva samples originated from 220 participants; 76 had generalized periodontitis (GP) 65 localized (LP), whereas 79 without were used as controls. Cytokine analyses performed by a flow cytometry-based technique...
Streptococcus suis causes sepsis, meningitis, and other serious infections in piglets, meningitis humans. Hemagglutination inhibition experiments with mono- oligosaccharides glycoproteins indicated that galactose-binding strains of S. recognized the Gal alpha 1-4Gal sequence present P1 Pk blood group antigen structures. In thin-layer chromatography overlay assays bacteria bound to trihexosylceramide (GbO3) but not globoside (GbO4) or Forssman glycolipid (GbO5), contrast P-fimbriated...
Pregnancy-associated gingivitis is a bacterial-induced inflammatory disease with remarkably high prevalence ranging from 35% to 100% across studies. Yet little known about the attendant mechanisms or diagnostic biomarkers that can help predict individual susceptibility for rational personalized medicine. We aimed define proteins in saliva, induced inhibited by estradiol, as early target relation pregnancy-associated gingivitis. An silico gene/protein interaction network model was developed...
Genetic factors play a role in periodontitis. Here we examined whether the risk haplotype of MHC class III region BAT1-NFKBIL1-LTA and lymphotoxin-α polymorphisms associate with salivary biomarkers periodontal disease. A total 455 individuals detailed clinical radiographic health data were included study. 610 K genotyping chip Sequenom platform used analyses. Phospholipid transfer protein activity, concentrations lymphotoxin-α, IL-8 myeloperoxidase, cumulative score (combining Porphyromonas...
A dual relationship between glycemic status and bone remodeling was suggested recently. The present study aimed to 1) analyze salivary levels of receptor activator for nuclear factor κ-B ligand (RANKL), osteoprotegerin, osteocalcin, osteopontin as potential biomarkers alveolar loss 2) determine whether the affects markers periodontal status.Salivary RANKL, osteopontin, serum glycosylated hemoglobin A1c, insulin, glucose were analyzed in 220 participants divided into four groups according...
Mannose-binding lectin (MBL) plays an important role in innate immunity. MBL deficiency is usually caused by mutations exon 1 of the structural gene (MBL2). Our aim was to investigate MBL2 polymorphisms and their relation salivary levels periodontal inflammatory/tissue destruction markers two major periodontitis-associated bacteria.Salivary samples from 222 subjects were available for genotyping pyrosequencing. The between 40 60 years age having a minimum 20 teeth divided into three groups:...
The cumulative risk score (CRS) is a mathematical salivary diagnostic model to define an individual’s of having periodontitis. In order further validate this biomarker, we investigated how periodontal bacteria, lipopolysaccharide (LPS), and systemic local host immune responses relate CRS. Subgingival plaque, saliva, serum samples collected from 445 individuals were used in the analyses. Plaque levels 28 microbial species, especially those Aggregatibacter actinomycetemcomitans, Porphyromonas...