A5065472999- Oral microbiology and periodontitis research
- Salivary Gland Disorders and Functions
- Immune Response and Inflammation
- Antimicrobial Peptides and Activities
- Oral Health Pathology and Treatment
- Oral and gingival health research
- Periodontal Regeneration and Treatments
- Protease and Inhibitor Mechanisms
- HIV/AIDS oral health manifestations
- Endodontics and Root Canal Treatments
- Dental Implant Techniques and Outcomes
- Dental Radiography and Imaging
- S100 Proteins and Annexins
- Streptococcal Infections and Treatments
- Proteoglycans and glycosaminoglycans research
- Bacterial biofilms and quorum sensing
- Laser Applications in Dentistry and Medicine
- Bacterial Identification and Susceptibility Testing
- Diabetes and associated disorders
- NF-κB Signaling Pathways
- Peptidase Inhibition and Analysis
- interferon and immune responses
- Dental materials and restorations
- Bone Tissue Engineering Materials
- Infant Nutrition and Health
University of Turku
2016-2025
Afyon Kocatepe University
2024
Varsinais-Suomen Sairaanhoitopiiri
2024
Turku City Hospital
2022-2024
University of Bergen
2022
Umeå University
2022
American Academy of Arts and Sciences
2022
University of Copenhagen
2022
Helsinki University Hospital
2008-2015
Finnish Institute for Health and Welfare
2010-2014
Pregnancy has been presented to increase susceptibility gingival inflammation. It is unclear whether pregnancy gingivitis exposes or proceeds periodontitis. We examined longitudinally the severity of periodontal changes during and post-partum, compared findings with an age-matched group non-pregnant women.Thirty generally healthy, non-smoking women at early phase their 24 as controls were recruited. The pregnant was three times twice times, once per subsequent month. At each visit, visible...
Salivary protein levels have been studied in periodontitis. However, there is lack of information on salivary cytokine early gingival inflammation. The aim this study was to determine vascular endothelial growth factor (VEGF), interleukin (IL)-8, monocyte chemoattractant (MCP)-1, IL-1β, and IL-1 receptor antagonist (IL-1Ra) Twenty-eight systemically orally healthy nonsmokers abstained from oral hygiene protocols for 10 days. After that, self-performed cleaning resumed 14 Plaque indexes were...
The former Bacteroides intermedius, currently including Prevotella intermedia and nigrescens, has been associated with hormone-induced pregnancy gingivitis. aim of the present longitudinal study was to determine whether only P. or both species, are involved in demonstrated microbial shift during pregnancy.Subgingival plaque saliva samples, collected from 30 healthy pregnant women 24 non-pregnant as their controls, were examined for presence pigmented gram-negative anaerobes. Altogether 2628...
Background : Estrogen regulates the cellular functions of several tissues that may disturb host response against bacteria. The present aim is to evaluate contribution estrogen severity gingival inflammation during pregnancy. Methods: Salivary levels from 30 pregnant and 24 non‐pregnant females were related their periodontal health parameters, including visible plaque index (VPI) bleeding on probing (BOP) six sites per tooth. group was examined three times pregnancy twice postpartum, times,...
To monitor salivary B-cell activating factor (BAFF), tumor necrosis factor-like weak inducer of apoptosis (TWEAK), and soluble (s)CD163 levels arginase activity in periodontitis patients following nonsurgical periodontal treatment.BAFF, TWEAK, sCD163 are associated with activities B cells macrophages, which important regulators immune-inflammatory response healing treatment. Increased BAFF have been demonstrated, but their changes treatment not evaluated before.Forty-four Stage III/IV 35...
ABSTRACT Objectives Smoking disrupts macrophage chemokine response and delays healing. This study aims to investigate the effect of smoking on peri‐implant crevicular fluid (PICF) levels macrophage‐related chemokines, C‐C motif ligand 2 (CCL‐2), 8 (CCL‐8), C‐X‐C 9 (CXCL‐9), 3 (CCL‐3), before after non‐surgical treatment initial peri‐implantitis. Methods Fifty‐five implants (27 non‐smoking [NSPI] 28 [SPI]) with peri‐implantitis (bleeding probing [BOP+], pocket depth [PPD] 6–7 mm) were...
To investigate the molecular forms of salivary matrix metalloproteinase (MMP)-8 in relation to periodontitis.Molecular forms, degree activation and fragmentation neutrophilic mesenchymal-type MMP-8 isoforms were analysed from samples 81 subjects with generalized periodontitis, 63 localized periodontitis 79 without pocket teeth, by using western-immunoblots computer quantitation. In addition, human recombinant proMMP-8 was vitro activated Treponema denticola chymotrypsin-like protease...
To profile gingival tissue levels of human beta-defensin (hBD)-2 and hBD-3 in relation to inflammation, Th17-related cytokine concentrations, Porphyromonas gingivalis counts, gingipain total protease activities.Gingival subgingival plaque samples were collected from 21 periodontitis patients including 48 periodontal pocket sites with marginal, mild, or moderate severe inflammation. hBD determined by immunodetection, P. counts real-time polymerase chain reaction, activities fluorogenic...
The diagnostic accuracy of point-of-care (PoC) applications may be compromised in individuals with additional inflammatory conditions. This cross-sectional study examined the performance a commercial oral rinse active matrix metalloproteinase-8 (aMMP-8) PoC immunotest (n = 47) and without Crohn’s disease (CD) 41). Oral collected from participants was analyzed by immunotest. Molecular forms fragments salivary MMP-8 were detected western immunoblotting. sensitivity for periodontitis 60.0% CD...
The oral innate immune response may diminish with aging. In the present study, aim was to examine human β-defensin (hBD) 1-3 and neutrophil peptide (HNP)-1 levels in saliva of an elderly population establish extent periodontal disease tooth loss. A total 175 individuals aged ≥ 65 years were divided into five groups based on number teeth a pocket depth 4 mm as follows: 17 pocket-free (Control), 55 having 1-6 (PerioA), 33 7-13 (PerioB), 29 at least 14 (PerioC), 41 edentulous individuals. Their...
Matrix metalloproteinases (MMPs) and their regulators are connected to periodontal inflammation destruction. However, the presence role of salivary MMPs in pregnancy-related gingivitis not well known. Our longitudinal study aimed monitor proteinase levels possible changes, relate them status during pregnancy postpartum.Salivary samples were collected from 30 periodontally healthy pregnant women five times (once each trimester, 4-6 wk after delivery lactation) and, as controls, 24...
Background: Pregnancy induces or enhances susceptibility to gingivitis; however, the presence and role of neutrophilic enzymes in pregnancy‐related gingivitis are not well known. The present study demonstrates relationship between gingival crevicular fluid (GCF) periodontal status during pregnancy postpartum. Methods: At baseline, 30 periodontally healthy pregnant women (Pr group) 24 non‐pregnant (N‐Pr as their controls participated study. Pr group was examined once per each trimester twice...
The objective of this study was to perform a landscape analysis apoptosis-related genes/proteins and the differential gene expression by analysing array data from periodontitis patients and, second, evaluate anti-apoptotic effects carvacrol, monoterpenoid phenol, in vitro.A gene/protein interaction network model 'APOP' developed using Search Tool for Retrieval Interacting Genes/Proteins (STRING) version 9.05. Differential determined limma package R false discovery rate (FDR). With ViaComplex...