A5101504964- Cardiovascular Function and Risk Factors
- Cardiac Imaging and Diagnostics
- Atrial Fibrillation Management and Outcomes
- Cardiac electrophysiology and arrhythmias
- Heart Failure Treatment and Management
- Cardiac Arrhythmias and Treatments
- Cardiovascular Disease and Adiposity
- Cardiac pacing and defibrillation studies
- Mitochondrial Function and Pathology
- Redox biology and oxidative stress
- Erythropoietin and Anemia Treatment
- Cardiovascular and exercise physiology
- Proteoglycans and glycosaminoglycans research
- Cardiac Ischemia and Reperfusion
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Chemotherapy-induced cardiotoxicity and mitigation
- Cardiac Valve Diseases and Treatments
- Aortic Disease and Treatment Approaches
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Peroxisome Proliferator-Activated Receptors
- Crystallization and Solubility Studies
- Adipokines, Inflammation, and Metabolic Diseases
- Crystallography and molecular interactions
- Heart Rate Variability and Autonomic Control
- Infective Endocarditis Diagnosis and Management
Hamamatsu University School of Medicine
2025
Uji Hospital
2018-2022
Setsunan University
2020
Pharmac
2020
Kagawa University Hospital
2019
Miwa Hospital
2017-2018
Fu Wai Hospital
2017
Chinese Academy of Medical Sciences & Peking Union Medical College
2017
Yamagata University
2011-2017
SAGE Publishing (United States)
2017
Various adipokines are reported to be associated with the development of heart failure (HF) through insulin resistance and chronic inflammation. Omentin-1 is a novel adipokine incident coronary artery disease. However, it remains unclear whether serum omentin-1 levels cardiac prognosis in patients HF. We measured at admission 136 consecutive HF, 20 control subjects without signs significant prospectively followed HF endpoints death or re-hospitalization for worsening Serum were markedly...
The response-to-tissue-injury theory is currently the favorite paradigm to investigate valve pathology. To best of our knowledge, there are no in vivo injury models. There few calcific aortic stenosis (AVS) models that develop hemodynamically significant stenosis. Here, we investigated effect direct mechanical on valves and developed a novel mouse model AVS.Aortic was created by inserting moving spring guidewire under echocardiographic guidance into left ventricle male C57/BL6 mice via right...
Background The homologous to the E6‐AP carboxyl terminus (HECT) –type ubiquitin E3 ligase ITCH is an enzyme that plays a pivotal role in posttranslational modification by proteasomal protein degradation. Thioredoxin‐interacting ( TXNIP ) negative regulator of thioredoxin system and endogenous reactive oxygen species scavenger. In present study, we focused on functional its interaction with elucidate mechanism cardiotoxicity induced , such as doxorubicin hydrogen peroxide. Methods Results...
Background Despite many recent advances in medicine, preventing the development of cardiovascular diseases remains a challenge. Heart-type fatty acid-binding protein (H-FABP) is marker ongoing myocardial damage and has been reported to be useful indicator for future events. However, it determined whether H-FABP can predict all-cause deaths general population. Methods Results This longitudinal cohort study included 3,503 subjects who participated community-based health checkup with 7-year...
Apoptosis of cardiomyocytes is thought to account for doxorubicin cardiotoxicity as it contributes loss myocardial tissue and contractile dysfunction. Given that high-mobility group box 1 (HMGB1) a nuclear DNA-binding protein capable inhibiting apoptosis, we aimed clarify the role HMGB1 in heat shock beta (HSPB1) expression during doxorubicin-induced cardiomyopathy.Mitochondrial damage, cardiomyocyte cardiac dysfunction after administration were significantly attenuated mice with...
Abstract Objectives Autopsy plays an essential role in detecting diagnostic errors and the findings from autopsies have potential to reduce future errors. However, there are few reports Japan on based autopsy diagnoses. This study aimed detail Japan. Methods descriptive utilized case report abstract database of Japanese Society Internal Medicine chapter meetings. cases 2002 2022 were included. We defined as discrepancies primary cause death between clinical diagnosis. Diagnostic error also...
An 83-year-old woman was referred to our emergency department with acute urticaria and sudden shortness of breath approximately 30 min after taking rectal diclofenac potassium for lumbago. After treatment adrenaline corticosteroids, the patient became hemodynamically stable left hospital on next day. She attended 1 week onset anaphylaxis because repeated postprandial epigastric pain. No abnormal lesions were found in endoscopy. Radiographic selective catheter angiography revealed chronic...
Midkine is a multifunctional growth factor, and its serum levels are increased with the functional severity of heart failure. This study aimed to examine role midkine in failure pathogenesis. expression were kidney lung after transverse aortic constriction (TAC) surgery, but not sufficiently heart. After TAC, phosphorylation extracellular signal-regulated kinase1/2 AKT, foetal genes considerably transgenic mice cardiac-specific overexpression (MK-Tg) compared wild-type (WT) mice. MK-Tg...
The aim of the present study was to examine relationship between myocardial damage caused by atrial fibrillation (AF) and subsequent cardiovascular events in AF patients with chronic heart failure (CHF).We measured serum levels heart-type fatty acid binding protein (H-FABP) high-sensitivity troponin T 402 consecutive CHF (CHF-AF, n=201) or sinus rhythm (CHF-SR, n=201). CHF-AF had higher H-FABP than those CHF-SR. In order prognostic value markers CHF-SR patients, we followed above analyzed...
In chronic kidney disease, activation of the epidermal growth factor receptor (EGFR) leads to cardiac hypertrophy, which affects morbidity and mortality. patients with renal insufficiency heart failure, expression midkine, a heparin-binding factor, is increased. Therefore, we investigated association between midkine EGFR in induction hypertrophy dysfunction disease. We performed subtotal nephrectomies midkine-knockout mice wild-type mice. found that nephrectomy-induced phosphorylation...
Early myocardial reperfusion is an effective therapy but ischemia/reperfusion (I/R) causes lethal injury. The aging heart was reported to show greater cardiac damage after I/R injury than that observed in young hearts. Senescence marker protein 30 (SMP30), whose expression decreases with age, plays a role reducing oxidative stress and apoptosis. However, the impact of SMP30 on remains be determined. In this study, left anterior descending coronary artery occluded for min, followed by...
Lithium is widely used to treat bipolar disorders. toxicity generally caused by inappropriately high doses of lithium or impaired excretion. Most eliminated via the kidneys and, since thyroid hormone increases tubular reabsorption lithium, thyrotoxicosis could contribute development toxicity. We report a case severe that was apparently precipitated onset resulting from silent thyroiditis and dehydration.The patient 64-year-old woman who admitted for muscle weakness in lower extremities,...
Diabetic patients often have coronary artery disease (CAD) without symptoms. It is known that females tend to silent or less chest pain and worse prognoses when they develop acute syndrome. Thus, sex differences may impact long-term outcomes in diabetes mellitus (DM) with myocardial ischemia (SMI). The present study aimed assess the influence of on DM SMI.A total 461 consecutive asymptomatic self-sufficient seen at our hospital from 2011 2017 were prospectively reviewed. Patients underwent...
Some asymptomatic patients with diabetes mellitus (DM) have critical coronary artery disease (CAD), although the guidelines do not recommend aggressive screening for CAD in patients. Chronic kidney (CKD) is among serious co-morbidities of severe systemic atherosclerosis. Thus, CKD may be associated potential myocardial ischaemia. Therefore, present study aimed to determine impact on incidence silent ischaemia (SMI) and long-term outcomes DM. This investigated 461 consecutive All who were...