A5076092034- Cardiovascular Function and Risk Factors
- Cardiac Imaging and Diagnostics
- Atrial Fibrillation Management and Outcomes
- Cardiac Arrhythmias and Treatments
- Cardiac electrophysiology and arrhythmias
- Heart Failure Treatment and Management
- Cardiac pacing and defibrillation studies
- Cerebrovascular and Carotid Artery Diseases
- Cardiac Valve Diseases and Treatments
- Cardiac Fibrosis and Remodeling
- Peripheral Artery Disease Management
- Cardiovascular Disease and Adiposity
- Gout, Hyperuricemia, Uric Acid
- Dialysis and Renal Disease Management
- Nutrition and Health in Aging
- Lipoproteins and Cardiovascular Health
- Acute Myocardial Infarction Research
- Cardiac Health and Mental Health
- Peroxisome Proliferator-Activated Receptors
- Nitric Oxide and Endothelin Effects
- Coronary Interventions and Diagnostics
- Adipose Tissue and Metabolism
- Chronic Kidney Disease and Diabetes
- Cardiovascular Health and Disease Prevention
- Blood Pressure and Hypertension Studies
Yamagata University
2016-2025
Yamagata University Hospital
2006-2022
SAGE Publishing (United States)
2017
Fu Wai Hospital
2017
University of Pecs
2017
Chinese Academy of Medical Sciences & Peking Union Medical College
2017
Creative Research Enterprises (United States)
2017
Fukushima Medical University
2016
Nagoya University
2016
American Heart Association
2014
Toll-like receptors (TLRs) are members of the interleukin-1 receptor family and transduce similar signals as in response to exogenous pathogens. Recent studies have demonstrated that TLRs activated by endogenous signals, such heat shock proteins oxidative stress, may contribute ventricular remodeling after myocardial infarction. In this study, we determined whether TLR-2 was involved cardiac infarction.Myocardial infarction induced surgical left anterior descending coronary artery ligation...
BackgroundThere is a residual risk of coronary heart disease (CHD) despite intensive statin therapy for secondary prevention. The aim this study was to investigate whether plaque regression and stabilization are reinforced by the addition eicosapentaenoic acid (EPA) high-dose pitavastatin (PTV).MethodsWe enrolled 193 CHD patients who underwent percutaneous intervention (PCI) in six hospitals. Patients were randomly allocated PTV group (PTV 4 mg/day, n = 96) or PTV/EPA mg/day EPA 1800 97),...
Background . Early identification of high risk subjects for cardiovascular disease in health check-up is still unmet medical need. Cardiovascular characterized by the superior increase aspartate aminotransferase (AST) to alanine (ALT). However, association AST/ALT ratio with brain natriuretic peptide (BNP) levels and mortality remains unclear general population. Methods Results This longitudinal cohort study included 3,494 Japanese who participated a community-based check-up, 10-year...
Background Resistin is derived from fat tissue in rodents, and serum levels are elevated animal models of obesity insulin resistance. Recent studies have reported that resistin correlated with markers inflammation oxidative stress predictive coronary atherosclerosis humans. However, clinical significance has not been examined heart failure. Therefore, the purpose this study was to examine whether: (1) severity failure; (2) can predict outcomes patients Methods Results Serum 126 hospitalized...
Various adipokines are reported to be associated with the development of heart failure (HF) through insulin resistance and chronic inflammation. Omentin-1 is a novel adipokine incident coronary artery disease. However, it remains unclear whether serum omentin-1 levels cardiac prognosis in patients HF. We measured at admission 136 consecutive HF, 20 control subjects without signs significant prospectively followed HF endpoints death or re-hospitalization for worsening Serum were markedly...
The response-to-tissue-injury theory is currently the favorite paradigm to investigate valve pathology. To best of our knowledge, there are no in vivo injury models. There few calcific aortic stenosis (AVS) models that develop hemodynamically significant stenosis. Here, we investigated effect direct mechanical on valves and developed a novel mouse model AVS.Aortic was created by inserting moving spring guidewire under echocardiographic guidance into left ventricle male C57/BL6 mice via right...
Peripheral artery disease (PAD) is an athero-occlusive and a known risk factor for cardiovascular events. The controlling nutritional status (CONUT) score geriatric index (GNRI) are objective tools evaluating malnutrition reportedly associated with poor clinical outcomes in patients fatal diseases. However, the effect of on PAD remains unclear.Methods Results:We enrolled 357 who underwent endovascular therapy. Malnutrition was diagnosed by CONUT GNRI as previous reports. During median...
Calcific aortic valve stenosis (CAVS) is the most common valvular heart disease and increased with elderly population. However, effective drug therapy has not been established yet. This study aimed to investigate role of microRNAs (miRs) in development CAVS.We measured expression 10 miRs, which were reportedly involved calcification by using human tissue from patients who underwent replacement CAVS or regurgitation (AR) porcine interstitial cells (AVICs) after treatment osteogenic induction...
Background The homologous to the E6‐AP carboxyl terminus (HECT) –type ubiquitin E3 ligase ITCH is an enzyme that plays a pivotal role in posttranslational modification by proteasomal protein degradation. Thioredoxin‐interacting ( TXNIP ) negative regulator of thioredoxin system and endogenous reactive oxygen species scavenger. In present study, we focused on functional its interaction with elucidate mechanism cardiotoxicity induced , such as doxorubicin hydrogen peroxide. Methods Results...
Hypertension is a major public health problem among the aging population worldwide. It causes cardiac remodeling, including hypertrophy and interstitial fibrosis, which leads to development of hypertensive heart disease (HHD). Although microRNA-21 (miR-21) associated with fibrogenesis in multiple organs, its contribution remodeling hypertension poorly understood. Circulating miR-21 level was higher patients HHD than that control subjects. also positively correlated serum myocardial fibrotic...
Diacylglycerol is a lipid second messenger that accumulates in cardiomyocytes when stimulated by Gqalpha protein-coupled receptor (GPCR) agonists such as angiotensin II, phenylephrine, and others. functions potent activator of protein kinase C (PKC) catalyzed diacylglycerol (DGK) to form phosphatidic acid inactivated. However, the functional roles DGK have not been previously examined heart. We hypothesized might prevent GPCR agonist-induced activation downstream signaling cascades...
The aim of the trial was to evaluate effectiveness a program cooperation between physician and pharmacist reduce cardiovascular risk factors in patients with mild moderate hypertension by promoting better blood pressure (BP) control, appropriate changes antihypertensive medications, beneficial lifestyle.The 132 subjects this randomized, controlled were age range 40-79 years. inclusion criteria were: systolic BP (SBP) ranging from 140-179 mm Hg and/or diastolic (DBP) 90-99 treatment-naive...
Background Heart-type fatty acid-binding protein (H-FABP) is a small cytosolic that released into the circulation when myocardium injured. This study examined whether serial measurement of H-FABP level provides additional prognostic information. Methods and Results Serum levels were measured in 113 consecutive chronic heart failure (CHF) patients at both admission discharge. The following 3 patterns changes identified. In 41 patients, (<4.3 ng/ml) discharge normal (Group 1). remaining 72 had...