A5052510955- Cardiac electrophysiology and arrhythmias
- Atrial Fibrillation Management and Outcomes
- Sleep and Wakefulness Research
- Cardiac Arrhythmias and Treatments
- Cardiac Imaging and Diagnostics
- Circadian rhythm and melatonin
- ECG Monitoring and Analysis
- Coronary Interventions and Diagnostics
- Coronary Artery Anomalies
- Cardiac pacing and defibrillation studies
- Cardiovascular Function and Risk Factors
- Cardiovascular Effects of Exercise
- Regulation of Appetite and Obesity
- Sleep and related disorders
- Neurobiology and Insect Physiology Research
- Cardiac Health and Mental Health
- Antiplatelet Therapy and Cardiovascular Diseases
- Chemotherapy-induced cardiotoxicity and mitigation
- Liver Disease Diagnosis and Treatment
- Pain Management and Treatment
- Natural Products and Biological Research
- Vitamin C and Antioxidants Research
- Health and Well-being Studies
- Algal biology and biofuel production
- Electrolyte and hormonal disorders
Tsukuba International University
2016-2024
University of Tsukuba
2016-2024
Showa University Fujigaoka Hospital
2000-2011
Chiba Institute of Technology
2007
Mammals exhibit circadian cycles of sleep and wakefulness under the control suprachiasmatic nucleus (SCN), such as strong arousal phase-locked to beginning dark phase in laboratory mice. Here, we demonstrate that salt-inducible kinase 3 (SIK3) deficiency gamma-aminobutyric acid (GABA)-ergic neurons or neuromedin S (NMS)-producing delayed peak lengthened behavioral cycle both 12-h light:12-h condition (LD) constant (DD) without changing daily amounts. In contrast, induction a gain-of-function...
Abstract Although sleep is one of the most conserved behaviors, intracellular mechanism regulating sleep/wakefulness remains unknown. We recently identified a protein kinase, SIK3, as sleep-regulating molecule. Mice that lack well-conserved kinase A (PKA) phosphorylation site, S551, showed longer non-rapid eye movement (NREM) and increased NREMS delta density. S551 SIK3 in other members SIK family, such SIK1 (S577) SIK2 (S587). Here, we examined whether PKA sites are involved regulation by...
We investigated the risk of upper gastrointestinal (UGI) bleeding and protective effect concomitant anti-secretory drugs during dual antiplatelet therapy administered following implantation drug-eluting stents (DES) for coronary heart disease. Because proton pump inhibitors (PPIs) are reported to decrease platelet inhibitory effects clopidogrel, we also assessed cardiovascular outcomes in patients taking thienopyridine derivatives with or without drug.We retrospectively analyzed 243...
Sleep/wakefulness is regulated by intracellular signaling pathways composed of protein kinases such as salt-inducible kinase 3 (Sik3). Sik3-deficiency in neurons decreases NREM sleep time and electroencephalogram (EEG) delta power during sleep, while Sik3Slp mice lacking a A (PKA)-phosphorylation site, S551, show hypersomnia phenotype. In this study, we examined how phosphomimetic mutation the 221st threonine residue (T221E), which provides partial (weak) constitutive activity kinase,...
The discovery of leptin substantiated the usefulness a forward genetic approach in elucidating molecular network regulating energy metabolism. However, no successful dominant screening for obesity has been reported, which may be due to influence quantitative trait loci between and counter strains low fertility obese mice. Here, we performed using C57BL/6 substrains, C57BL/6J C57BL/6N, with routine use vitro fertilization. more than 5000 mutagenized mice established two pedigrees single...
Abstract Background There are limited reports on mineralocorticoid-responsive hyponatraemia of the elderly (MRHE), a condition that can cause severe hyponatraemia. Case summary An 85-year-old woman presented with transient loss consciousness and nausea likely due to untreated (114 mEq/L). Thirty-nine hours after initial admission, she developed sudden cardiac dysfunction entered circulatory collapse state. The patient was diagnosed Takotsubo syndrome. Her an essential feature syndrome...
Background: Pulmonary vein isolation (PVI) is expected to cure atrial fibrillation (AF) and improve remodeling. However, the effects of PVI on right (RA) size have not been fully examined. We studied RA in comparison that with LA size. Method: 17 patients drug-refractory AF (11 paroxysmal, 6 persistent). Two-dimensional echocardiography was performed at baseline follow-up measure compare size.Results: Despite a short duration 7 after PVI, all cases were maintained sinus rhythm during...
In addition to the well-known motor control, cerebellum has recently been implicated in memory, cognition, addiction, and social behavior. Given that contains more neurons than cerebral cortex tight connections thalamus brainstem nuclei, it is possible also regulates sleep/wakefulness. However, role of sleep was unclear, since cerebellar lesion studies inevitably involved massive inflammation adjacent brainstem, changes were not consistent with each other. Here, we examine wakefulness using...