A5077718373- Pulmonary Hypertension Research and Treatments
- Neuroscience and Neuropharmacology Research
- Memory and Neural Mechanisms
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Sleep and Wakefulness Research
- Sarcoidosis and Beryllium Toxicity Research
- Neurogenesis and neuroplasticity mechanisms
- Photoreceptor and optogenetics research
- Cardiovascular Function and Risk Factors
- Receptor Mechanisms and Signaling
- Occupational exposure and asthma
- Diet and metabolism studies
- Tryptophan and brain disorders
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Diabetes and associated disorders
- Biochemical Analysis and Sensing Techniques
- Venous Thromboembolism Diagnosis and Management
- Hearing, Cochlea, Tinnitus, Genetics
- Neuroendocrine regulation and behavior
- Circadian rhythm and melatonin
- Neonatal and fetal brain pathology
- Advanced Glycation End Products research
- Transplantation: Methods and Outcomes
- Congenital heart defects research
- Biochemical effects in animals
Seirei Hamamatsu General Hospital
2021-2025
Chiba University
2016-2024
National Institute of Mental Health
2020-2024
National Center of Neurology and Psychiatry
2019-2024
Gunma University
2009-2024
Seirei Mikatabara General Hospital
2024
Tokyo Metropolitan Institute of Medical Science
2020-2023
NTL Institute for Applied Behavioral Science
2021
Terumo (Japan)
2019
Harvard University
2017-2018
Cortical interneurons are classified into several subtypes that contribute to cortical oscillatory activity. Parvalbumin (PV)-expressing cells, a type of inhibitory interneuron, involved in the gamma oscillations local field potentials (LFPs). Under ketamine-xylazine anesthesia or sleep, mammalian circuits exhibit slow which active-up state and silent-down alternate at ~1 Hz. The up is composed various high-frequency oscillations, including oscillations. However, it unclear how PV cells...
Ca 2 + -dependent activator protein for secretion (CAPS2 or CADPS2) potently promotes the release of brain-derived neurotrophic factor (BDNF). A rare splicing form CAPS2 with deletion exon3 (dex3) was identified to be overrepresented in some patients autism. Here, we generated Caps2 -dex3 mice and verified a severe impairment axonal Caps2-dex3 localization, contributing reduction BDNF from axons. In addition, circuit connectivity, measured by spine interneuron density, diminished globally....
The pathogenesis of pulmonary arterial hypertension is closely associated with dysregulated inflammation. Recently, abnormal alterations in gut microbiome composition and function were reported a experimental animal model. However, it remains unclear whether these are result or the cause hypertension. purpose this study was to investigate affected hemodynamics SU5416/hypoxia rats. We used rat model our study. rats treated single SU5416 injection (30 mg/kg) three-week hypoxia exposure (10% O
Background: Mycobacterium avium complex lung disease (MAC-LD) is a chronic, progressive, potentially life-threatening infection. Some cases are refractory to standard guideline-based therapy (GBT), and sputum cultures persistently positive for acid-fast bacilli. Although an early identification of treatment-refractory MAC-LD crucial, its risk factors remain unknown. Objectives: We aimed identify the in response initial GBT. Design: A retrospective single-center study was conducted involving...
The NMDA-type glutamate receptor is a heteromeric complex composed of the NR1 and at least one NR2 subunits. Switching from NR2B to NR2A subunit thought underlie functional alteration NMDA during synaptic maturation, it generally believed that results in preferential localization subunits on site extracellular mature brain. It has also been proposed activation long-term potentiation (LTP) depression (LTD), respectively. Furthermore, recent reports suggest extrasynaptic receptors may have...
High-sugar diet in adolescence induces neural angiopathy and multiple psychiatric endophenotypes with impaired glucose logistics.
The neurogenic gene Drosophila big brain (bib) has a high sequence homology to aquaporin-4. However, its cellular functions in neurogenesis have remained elusive. Here we investigated cell adhesion, and the ion water permeability of Bib. adhesive function was examined by aggregation assay using L cells. Bib-transfected cells formed aggregated clusters, while control-L as single suspension. Ion permeation not confirmed stably expressing When expressed COS7 cells, Bib exhibited limited...
Several new treatments for chronic thromboembolic pulmonary hypertension (CTEPH) have appeared in recent years, which led to changes the treatment algorithm. Changes survival rates and prognostic factors, however, not been estimated so far.Methods Results:Two hundred eighty patients were diagnosed with CTEPH at Chiba University Hospital between June 1986 2016. Survival rate was investigated by date of initiation (group 1, 1986-1998; group 2, 1999-2008; 3, 2009-2016). also evaluated strategy:...
In chorioamnionitis, intra-amniotic infections render the amniotic fluid an adverse environment for fetus and increase risk of fetal mortality morbidity. It remains unclear how infection crosses barrier, which is made up tight junctions (TJs). this study, we investigated whether TJs are disrupted in inflammatory conditions such as chorioamnionitis. Amniotic were by single applications interleukin (IL)-1β, IL-6, tumour necrosis factor-α (TNF-α), prostaglandin E2. organ-cultured membranes,...
It is generally considered that there an increase in glycolysis the hypertrophied right ventricle (RV) during pulmonary hypertension (PH), which leads to a decrease glucose oxidation through tricarboxylic acid (TCA) cycle. Although recent studies have demonstrated fatty (FA) and accumulated RV of patients with PH, details this remain be elucidated. The purpose current study was assess metabolic remodeling rats PH using analysis. Male were treated vascular endothelial growth factor receptor...
Idiopathic pleuroparenchymal fibroelastosis (IPPFE) is a rare form of idiopathic interstitial pneumonias; its physical characteristics include slender build with platythorax and progressive weight loss. However, the clinical significance body mass index (BMI) loss remains unclear in patients IPPFE. Therefore, we aimed to clarify association between baseline BMI, after diagnosis, prognosis
Patients with chronic thromboembolic pulmonary hypertension (CTEPH) require lifelong anticoagulation therapy. However, the bleeding risk and recurrence of venous thromboembolism (VTE) in CTEPH patients who are administered warfarin have not been adequately evaluated. The purpose this study was to evaluate clinically relevant bleeding, recurrent VTE, clinical worsening were warfarin. records 72 regularly visited our institution retrospectively reviewed between 1 January 2011 31 December 2015....
The Slitrk family consists of six synaptic adhesion molecules, some which are associated with neuropsychiatric disorders. In this study, we aimed to investigate the physiological role Slitrk4 by analyzing knockout (KO) mice. protein was widely detected in brain and abundant olfactory bulb amygdala. a systematic behavioral analysis, male KO mice exhibited an enhanced fear memory acquisition cued test for classical conditioning, social behavior deficits reciprocal interaction tests....
Background:Mean pulmonary arterial pressure (MPAP) is an important hemodynamic parameter used in the management of patients with chronic thromboembolic hypertension (CTEPH). We compared echocardiography-derived estimates MPAP right heart catheterization (RHC) to identify reliable noninvasive methods estimating MPAP-derived RHC (MPAPRHC) these patients.Methods and Results:Echocardiography were performed 56 CTEPH (60.5±12.0 years; 44 females). measured tricuspid regurgitation (TR) gradient...
Abstract The neuropeptide oxytocin (Oxt) plays important roles in modulating social behaviors. Oxt receptor (Oxtr) is abundantly expressed the brain and its relationship to socio-behavioral controls has been extensively studied using mouse brains. Several genetic tools visualize and/or manipulate Oxtr-expressing cells, such as fluorescent reporters Cre recombinase drivers, have generated by ES-cell based gene targeting or bacterial artificial chromosome (BAC) transgenesis. However, these...
Chronic thromboembolic pulmonary hypertension (CTEPH) can cause right heart failure. A concomitant psychiatric disorder (PD) is thought to increase the risk of acute thromboembolism; however, whether PDs are associated with deterioration in CTEPH pathophysiology unclear. In this study, we evaluated clinical characteristics and prognoses patients a co‐existing PD. We retrospectively identified 229 consecutive (mean age = 58.7 ± 12.5 years; 160 women) categorized them according they had PD (PD...