A5029441483- Heart Failure Treatment and Management
- Cardiovascular Function and Risk Factors
- Cardiac Imaging and Diagnostics
- Nutrition and Health in Aging
- Peripheral Artery Disease Management
- Acute Myocardial Infarction Research
- Gout, Hyperuricemia, Uric Acid
- GDF15 and Related Biomarkers
- Atherosclerosis and Cardiovascular Diseases
- Cerebrovascular and Carotid Artery Diseases
- Atrial Fibrillation Management and Outcomes
- Cardiac Fibrosis and Remodeling
- Potassium and Related Disorders
- Macrophage Migration Inhibitory Factor
- Cardiac Health and Mental Health
- MicroRNA in disease regulation
- Cardiac Valve Diseases and Treatments
- Cardiovascular Health and Disease Prevention
- Circular RNAs in diseases
- Pericarditis and Cardiac Tamponade
- Renal and Vascular Pathologies
- Cardiac Arrhythmias and Treatments
- Peptidase Inhibition and Analysis
- Aortic aneurysm repair treatments
- Cardiomyopathy and Myosin Studies
Yamagata University
2008-2025
Yamagata University Hospital
2022
Yamagata Prefectural Central Hospital
2016
Medical University of South Carolina
1995-1996
Tottori University
1987
The fibrillar collagen network is postulated to be a primary determinant of left ventricular diastolic stiffness. This hypothesis was tested by examining the structural and physiological effects reduction in content cross-linking intact ventricle. Collagen inhibited treating five normal adult pigs with beta-aminopropionitrile (BAPN; 10 g/day po) for 6 wk; untreated served as controls. Left volume, mass, function were determined simultaneous echocardiography catheterization. Chamber...
Calcific aortic valve stenosis (CAVS) is the most common valvular heart disease and increased with elderly population. However, effective drug therapy has not been established yet. This study aimed to investigate role of microRNAs (miRs) in development CAVS.We measured expression 10 miRs, which were reportedly involved calcification by using human tissue from patients who underwent replacement CAVS or regurgitation (AR) porcine interstitial cells (AVICs) after treatment osteogenic induction...
Hypertension is a major public health problem among the aging population worldwide. It causes cardiac remodeling, including hypertrophy and interstitial fibrosis, which leads to development of hypertensive heart disease (HHD). Although microRNA-21 (miR-21) associated with fibrogenesis in multiple organs, its contribution remodeling hypertension poorly understood. Circulating miR-21 level was higher patients HHD than that control subjects. also positively correlated serum myocardial fibrotic...
Left ventricular reverse remodeling (LVRR) is associated with a good prognosis in patients dilated cardiomyopathy (DCM), so this study we examined the achievement rates of LVRR, time taken to LVRR and factors recent cases DCM. We enrolled 121 was defined as left ejection fraction ≥40% at follow-up ≥10% improvement. observed 82 (68%). The median 208 days. Multivariate analysis revealed that B-type natriuretic peptide (BNP) levels discharge (per 1-SD increase, odds ratio: 0.483, 95% confidence...
Abstract Aims Heart failure with preserved ejection fraction (HFpEF) continues to be an increasingly common health problem associated a high mortality rate. Elevated levels of Growth differentiation factor‐15 (GDF15) and N‐terminal pro‐brain natriuretic peptide (NT‐proBNP) are reportedly poor clinical outcomes in broad range cardiovascular diseases. The aim the present study was examine effect combined assessment these markers on patients HFpEF. Methods This is prospective observational...
Abstract Aims Despite advances in heart failure (HF) treatment, HF with preserved ejection fraction (HFpEF) remains a health problem high mortality rate. HFpEF is composed of diverse phenogroups, which patients concomitant renal impairment have worse outcomes. Renal tubular damage (RTD) associated the development and chronic kidney disease (CKD). However, impact RTD on progression CKD unclear. The aim present study was to examine whether could predict HF‐related events CKD. Methods results...
Background Peripheral pulmonary artery stenosis (PPS) refers to of the from trunk peripheral arteries. Although paediatric PPS is well described, clinical characteristics adult-onset idiopathic have not been established. Our objectives in this study were characterise disease profile PPS. Methods We collected data Japanese centres. This cohort included patients who underwent angiography (PAG) and excluded with chronic thromboembolic hypertension or Takayasu arteritis. Patient backgrounds,...
Abstract Aims Reactive oxygen species are reportedly involved in the mechanism underlying heart failure with preserved ejection fraction (HFpEF); however, disease pathophysiology remains poorly understood. Xanthine oxidoreductase (XOR), rate‐limiting enzyme of purine metabolism, plays an important role uric acid production and generates reactive species. However, impact plasma XOR activity on clinical outcomes patients HFpEF unclear. The aim this study was to investigate whether is...
The HECT (homologous to the E6-AP carboxyl terminus)-type ubiquitin E3 ligase ITCH is an enzyme that plays important role in ubiquitin-proteasomal protein degradation. Disheveled proteins (Dvl1 [disheveled 1], Dvl2, and Dvl3) are main components of Wnt/β-catenin signaling pathway, which involved cardiac hypertrophy. aim this study was examine during development Thoracic transverse aortic constriction (TAC) performed transgenic mice with cardiac-specific overexpression (ITCH-Tg) wild-type...
Heart failure (HF) is an increasing health problem associated with a high mortality rate. Growth differentiation factor (GDF) 15, stress response cytokine belonging to the transforming growth factor-β superfamily, poor clinical outcomes in broad spectrum of cardiovascular diseases. However, prognostic usefulness GDF15 Japanese patients HF remains unclear.
Chronic supraventricular pacing tachycardia (SVT) causes abnormalities in both ventricular and cellular relaxation. The mechanisms causing these have not been fully determined. To examine two of the possible mechanisms, a decrease restoring force or an impairment intrinsic myocardial relaxation process, cardiocytes were enzymatically isolated from left ventricle pigs subjected to atrial at 240 beats/min for 3 wk normal control pigs. SVT caused extent cardiocyte shortening velocity...
Xanthine oxidoreductase (XOR) is the rate-limiting enzyme in uric acid (UA) production that plays a pivotal role generating oxidative stress. Gender differences impact of plasma XOR activity on coronary artery spasm (CAS) remain unclear. We investigated 132 patients suspected having CAS (male, n = 78; female, 54) and who underwent an intracoronary acetylcholine provocation test. Plasma was significantly lower female compared with male patients. provoked 36 17 patients, both had higher than...
Malnutrition, glomerular damage (GD), and renal tubular (RTD) are common morbidities associated with poor clinical outcomes in heart failure (HF) patients. However, the association between malnutrition dysfunction its impact on HF patients have not yet been fully elucidated. We assessed nutritional status function of 1061 consecutive GD, RTD were defined as a controlling (CONUT) score ≥ 5, reduced eGFR or microalbuminuria, levels N-acetyl-beta-D-glucosamidase > 14.2 U/gCr according to...
It has been hypothesized that the changes in myocardial stiffness induced by chronic hemodynamic overloading are dependent on passive of cardiac muscle cell (cardiocyte). However, no previous studies have examined constitutive properties cardiocytes isolated from animals with hypertrophy. Accordingly, relative pressure- or volume-overload hypertrophy were determined examining effects anisosmotic stress cardiocyte size. Anisosmotic was produced altering superfusate osmolarity. Hypertrophied...
Despite a reduction in the rate of thrombotic events, ischemic heart disease (IHD) remains key medical problem associated with high major bleeding and mortality Asian patients IHD. Growth differentiation factor (GDF)-15, stress-response cytokine belonging to transforming growth beta superfamily, is reportedly poor clinical outcomes Western However, significance GDF-15 IHD has not yet been fully elucidated.
metabolism and renal excretion.The clearance of BNP depends on neutral endopeptidase-dependent degradation receptor-mediated degradation. 8BNP acts as an active hormone with vasodilatory diuretic effects that reduce left ventricular (LV) overload. 9In contrast, NT-proBNP is excreted from the kidney without any has a longer half-life than BNP. 10 Despite these differences, both are useful biomarkers for identification HF patients high risk cardiac events. 5,11Natriuretic peptide level...
Lower extremity artery disease (LEAD) is an increasingly common health problem that associated with high mortality due to thrombotic and bleeding events. Growth differentiation factor-15 (GDF15), a stress-response cytokine belonging the transforming growth factor-beta superfamily, cardiovascular its outcomes. The aim of present study was examine effect serum GDF15 levels on clinical outcomes in patients LEAD.