A5102779289- Cardiac Arrhythmias and Treatments
- Congenital Heart Disease Studies
- Gout, Hyperuricemia, Uric Acid
- Cardiac Imaging and Diagnostics
- Cardiovascular Function and Risk Factors
- Cardiac Valve Diseases and Treatments
- Atrial Fibrillation Management and Outcomes
- Peripheral Artery Disease Management
- Cardiac electrophysiology and arrhythmias
- Aortic Disease and Treatment Approaches
- Neuropeptides and Animal Physiology
- Metabolism and Genetic Disorders
- Cardiac Fibrosis and Remodeling
- Cardiac Structural Anomalies and Repair
- Cerebrovascular and Carotid Artery Diseases
- Pulmonary Hypertension Research and Treatments
- Inflammasome and immune disorders
- Transplantation: Methods and Outcomes
- Cardiac Ischemia and Reperfusion
- Cardiac pacing and defibrillation studies
- Hormonal Regulation and Hypertension
- Cardiovascular Disease and Adiposity
- MicroRNA in disease regulation
- Nutrition and Health in Aging
- Circular RNAs in diseases
Yamagata Prefectural Central Hospital
2025
Kitano Hospital
2009-2024
Jikei University School of Medicine
2024
Yamagata University
2017-2023
University of Colorado Anschutz Medical Campus
2018
University of Colorado Denver
2017-2018
Sumitomo Dainippon Pharma (Japan)
2015
Niigata University
2012
National Cerebral and Cardiovascular Center
1999-2007
Fukushima Medical University
2006
Peripheral artery disease (PAD) is an athero-occlusive and a known risk factor for cardiovascular events. The controlling nutritional status (CONUT) score geriatric index (GNRI) are objective tools evaluating malnutrition reportedly associated with poor clinical outcomes in patients fatal diseases. However, the effect of on PAD remains unclear.Methods Results:We enrolled 357 who underwent endovascular therapy. Malnutrition was diagnosed by CONUT GNRI as previous reports. During median...
Calcific aortic valve stenosis (CAVS) is the most common valvular heart disease and increased with elderly population. However, effective drug therapy has not been established yet. This study aimed to investigate role of microRNAs (miRs) in development CAVS.We measured expression 10 miRs, which were reportedly involved calcification by using human tissue from patients who underwent replacement CAVS or regurgitation (AR) porcine interstitial cells (AVICs) after treatment osteogenic induction...
Hypertension is a major public health problem among the aging population worldwide. It causes cardiac remodeling, including hypertrophy and interstitial fibrosis, which leads to development of hypertensive heart disease (HHD). Although microRNA-21 (miR-21) associated with fibrogenesis in multiple organs, its contribution remodeling hypertension poorly understood. Circulating miR-21 level was higher patients HHD than that control subjects. also positively correlated serum myocardial fibrotic...
Post-infarction scar-related ventricular tachycardia (VT) originating from the right (RV) free wall in patients with RV infarction is rare. A 75-year-old Asian male, a history of after surgery for giant coronary artery aneurysm, presented sustained VT left bundle branch block and inferior axis morphology. The activation mapping during revealed focal origin initially propagated anterior attachment wall, mid-diastolic potentials (MDPs) were detected within close to attachment. At MDPs...
Background— Impaired cardiac autonomic nervous activities and increased neurohumoral (CANA, NHA) characterize Fontan patients. However, the clinical significance of these changes is not clearly understood. Our purpose was to clarify CANA NHA in stable Methods Results— We divided 22 atriopulmonary connection (APC) 75 total cavopulmonary (TCPC) patients into 4 subgroups according New York Heart Association (NYHA) class (1.8±0.6) measured various indices. All indices were elevated symptomatic (...
The prognosis of peripheral artery disease (PAD) and comorbid sarcopenia is poor. Some reports indicate that the computed tomography (CT) value skeletal muscle, which reflects intramuscular fat deposition as well muscle mass, considered a marker sarcopenia. However, it remains unclear if area CT are associated with poor outcomes in patients PAD. Methods Results: Psoas were measured by manual trace at level third lumbar vertebral body 327 consecutive PAD undergoing endovascular therapy (EVT)....
High-mobility group box 1 (HMGB1) is a deoxyribonucleic acid (DNA)–binding protein associated with DNA repair. Decreased nuclear HMGB1 expression and increased damage response (DDR) were observed in human failing hearts. DDR as well cardiac remodeling suppressed cardiac-specific overexpression transgenic mice after angiotensin II stimulation compared wild-type mice. In vitro, inhibition of phosphorylation extracellular signal-related kinase 1/2 factor kappa B, which was rescued by inhibitor...
Few investigators have examined the outcome of patients with isolated congenital complete atrioventricular block (CCAVB) paced from neonatal period. The present study follows clinical course and describes who been CCAVB since they were neonates.The medical records 20 as neonates between 1981 2006 retrospectively studied reviewed; 18 diagnosed in utero 2 at birth. SS-A antibodies detected 9 14 (64%) mothers tested. median age follow-up was 5.6 years (range, days to 21.9 years). Three (15%)...
Abstract Aims Reactive oxygen species are reportedly involved in the mechanism underlying heart failure with preserved ejection fraction (HFpEF); however, disease pathophysiology remains poorly understood. Xanthine oxidoreductase (XOR), rate‐limiting enzyme of purine metabolism, plays an important role uric acid production and generates reactive species. However, impact plasma XOR activity on clinical outcomes patients HFpEF unclear. The aim this study was to investigate whether is...
The HECT (homologous to the E6-AP carboxyl terminus)-type ubiquitin E3 ligase ITCH is an enzyme that plays important role in ubiquitin-proteasomal protein degradation. Disheveled proteins (Dvl1 [disheveled 1], Dvl2, and Dvl3) are main components of Wnt/β-catenin signaling pathway, which involved cardiac hypertrophy. aim this study was examine during development Thoracic transverse aortic constriction (TAC) performed transgenic mice with cardiac-specific overexpression (ITCH-Tg) wild-type...
Pulmonary arterial hypertension (PAH) is a progressive fatal disease caused by pulmonary remodeling. Midkine regulates cell proliferation and migration, it induced hypoxia, but its roles in remodeling remain unclear. Serum midkine levels were significantly increased PAH patients compared with control patients. expression was lungs sera of hypoxia-induced mice. Hypoxia-induced right ventricular hypertrophy attenuated midkine-knockout Midkine-induced migration smooth muscle cells (PASMC)...
Peroxisome proliferator-activated receptors (PPARs) play a key regulating role in homeostasis. In this study, we investigated the effects of DSP-8658, novel selective PPARa/γ modulator, on adipogenesis and glucose metabolism diabetic obese mice compared these to those pioglitazone, PPARγ full agonist.DSP-8658 functional activity was assessed by PPARγ-target genes expression adipose 3T3-L1 cells its anti-diabetic efficacy evaluated db/db mice. The DSP-8658 were diet induced (DIO) KK-A(y)...
Xanthine oxidoreductase (XOR) is the rate-limiting enzyme in uric acid (UA) production that plays a pivotal role generating oxidative stress. Gender differences impact of plasma XOR activity on coronary artery spasm (CAS) remain unclear. We investigated 132 patients suspected having CAS (male, n = 78; female, 54) and who underwent an intracoronary acetylcholine provocation test. Plasma was significantly lower female compared with male patients. provoked 36 17 patients, both had higher than...
Infarct size (IS) reduction by ischemic preconditioning (IPC) has been assessed in the heart which coronary stenosis (CS)-induced chronic ischemia was not present. The aim of this study is to assess whether and how IS IPC modified CS occurred, further therapeutics, if any, modify it.We produced a 30-minute acute occlusion 24-hour reperfusion (COR) rat hearts had developed for 1-12 weeks. Modifications mitochondrial KATP channel (mitoKATP) opener blocker, effects daily beta-blocker treatment...