A5100887214- Cardiovascular Function and Risk Factors
- Atrial Fibrillation Management and Outcomes
- Cardiac Fibrosis and Remodeling
- Cardiac Ischemia and Reperfusion
- Peripheral Artery Disease Management
- Cerebrovascular and Carotid Artery Diseases
- Nitric Oxide and Endothelin Effects
- Cardiac Imaging and Diagnostics
- Heart Failure Treatment and Management
- Cardiac Arrhythmias and Treatments
- Cardiac electrophysiology and arrhythmias
- Nutrition and Health in Aging
- Aortic Disease and Treatment Approaches
- Cardiac Valve Diseases and Treatments
- Advanced Glycation End Products research
- Pulmonary Hypertension Research and Treatments
- MicroRNA in disease regulation
- Cardiovascular Health and Disease Prevention
- Protein Kinase Regulation and GTPase Signaling
- Proteoglycans and glycosaminoglycans research
- Receptor Mechanisms and Signaling
- Dialysis and Renal Disease Management
- Macrophage Migration Inhibitory Factor
- Potassium and Related Disorders
- Cardiovascular Health and Risk Factors
Sapporo Medical University
2025
Yamagata University
2015-2024
Tohoku University
2024
Yamagata University Hospital
2006-2022
Fukushima Medical University
2016
Nagoya University
2016
University of Rochester
2005
Case Western Reserve University
2005
University of Göttingen
2005
Osaka University
2003
Toll-like receptors (TLRs) are members of the interleukin-1 receptor family and transduce similar signals as in response to exogenous pathogens. Recent studies have demonstrated that TLRs activated by endogenous signals, such heat shock proteins oxidative stress, may contribute ventricular remodeling after myocardial infarction. In this study, we determined whether TLR-2 was involved cardiac infarction.Myocardial infarction induced surgical left anterior descending coronary artery ligation...
High mobility group box 1 (HMGB1) is an abundant and ubiquitous nuclear DNA-binding protein that has multiple functions dependent on its cellular location. HMGB1 binds to DNA, facilitating numerous including maintenance of genome stability, transcription, repair. However, little known about the effects cardiac hypertrophy heart failure. The aim this study was examine whether plays a role in development induced by pressure overload. Analysis human biopsy samples immunohistochemistry showed...
The response-to-tissue-injury theory is currently the favorite paradigm to investigate valve pathology. To best of our knowledge, there are no in vivo injury models. There few calcific aortic stenosis (AVS) models that develop hemodynamically significant stenosis. Here, we investigated effect direct mechanical on valves and developed a novel mouse model AVS.Aortic was created by inserting moving spring guidewire under echocardiographic guidance into left ventricle male C57/BL6 mice via right...
Peripheral artery disease (PAD) is an athero-occlusive and a known risk factor for cardiovascular events. The controlling nutritional status (CONUT) score geriatric index (GNRI) are objective tools evaluating malnutrition reportedly associated with poor clinical outcomes in patients fatal diseases. However, the effect of on PAD remains unclear.Methods Results:We enrolled 357 who underwent endovascular therapy. Malnutrition was diagnosed by CONUT GNRI as previous reports. During median...
Calcific aortic valve stenosis (CAVS) is the most common valvular heart disease and increased with elderly population. However, effective drug therapy has not been established yet. This study aimed to investigate role of microRNAs (miRs) in development CAVS.We measured expression 10 miRs, which were reportedly involved calcification by using human tissue from patients who underwent replacement CAVS or regurgitation (AR) porcine interstitial cells (AVICs) after treatment osteogenic induction...
Background The homologous to the E6‐AP carboxyl terminus (HECT) –type ubiquitin E3 ligase ITCH is an enzyme that plays a pivotal role in posttranslational modification by proteasomal protein degradation. Thioredoxin‐interacting ( TXNIP ) negative regulator of thioredoxin system and endogenous reactive oxygen species scavenger. In present study, we focused on functional its interaction with elucidate mechanism cardiotoxicity induced , such as doxorubicin hydrogen peroxide. Methods Results...
Hypertension is a major public health problem among the aging population worldwide. It causes cardiac remodeling, including hypertrophy and interstitial fibrosis, which leads to development of hypertensive heart disease (HHD). Although microRNA-21 (miR-21) associated with fibrogenesis in multiple organs, its contribution remodeling hypertension poorly understood. Circulating miR-21 level was higher patients HHD than that control subjects. also positively correlated serum myocardial fibrotic...
Diacylglycerol is a lipid second messenger that accumulates in cardiomyocytes when stimulated by Gqalpha protein-coupled receptor (GPCR) agonists such as angiotensin II, phenylephrine, and others. functions potent activator of protein kinase C (PKC) catalyzed diacylglycerol (DGK) to form phosphatidic acid inactivated. However, the functional roles DGK have not been previously examined heart. We hypothesized might prevent GPCR agonist-induced activation downstream signaling cascades...
Apoptosis of cardiomyocytes is thought to account for doxorubicin cardiotoxicity as it contributes loss myocardial tissue and contractile dysfunction. Given that high-mobility group box 1 (HMGB1) a nuclear DNA-binding protein capable inhibiting apoptosis, we aimed clarify the role HMGB1 in heat shock beta (HSPB1) expression during doxorubicin-induced cardiomyopathy.Mitochondrial damage, cardiomyocyte cardiac dysfunction after administration were significantly attenuated mice with...
Diacylglycerol (DAG) is a lipid second messenger that transiently accumulates in cells stimulated by endothelin-1 (ET-1) and other Galphaq protein-coupled receptor agonists. kinase (DGK) thought to be an enzyme controls the cellular levels of DAG converting it phosphatidic acid; however, functional role DGK has not been examined cardiomyocytes. Because inactivates DAG, strong activator protein C (PKC), we hypothesized inhibited ET-1-induced activation DAG-PKC signaling cascade subsequent...
Midkine is a multifunctional growth factor, and its serum levels are increased with the functional severity of heart failure. This study aimed to examine role midkine in failure pathogenesis. expression were kidney lung after transverse aortic constriction (TAC) surgery, but not sufficiently heart. After TAC, phosphorylation extracellular signal-regulated kinase1/2 AKT, foetal genes considerably transgenic mice cardiac-specific overexpression (MK-Tg) compared wild-type (WT) mice. MK-Tg...
High-mobility group box 1 (HMGB1) is a deoxyribonucleic acid (DNA)–binding protein associated with DNA repair. Decreased nuclear HMGB1 expression and increased damage response (DDR) were observed in human failing hearts. DDR as well cardiac remodeling suppressed cardiac-specific overexpression transgenic mice after angiotensin II stimulation compared wild-type mice. In vitro, inhibition of phosphorylation extracellular signal-related kinase 1/2 factor kappa B, which was rescued by inhibitor...
Abstract Aims Despite advances in heart failure (HF) treatment, HF with preserved ejection fraction (HFpEF) remains a health problem high mortality rate. HFpEF is composed of diverse phenogroups, which patients concomitant renal impairment have worse outcomes. Renal tubular damage (RTD) associated the development and chronic kidney disease (CKD). However, impact RTD on progression CKD unclear. The aim present study was to examine whether could predict HF‐related events CKD. Methods results...
Aim: Recently, there has been an increase in the prevalence of coronary risk factors, such as diabetes and dyslipidemia, Japan; however, it is unclear whether this resulted increased incidence acute myocardial infarction (AMI). We investigated relationship between factors changes AMI a Japanese population.Methods: Trends (per 100,000 person-years) were examined using data from Yamagata Registry 1993 to 2007. included 6,222 patients with first-ever (4175 men). The was three age groups (<65,...
The HECT (homologous to the E6-AP carboxyl terminus)-type ubiquitin E3 ligase ITCH is an enzyme that plays important role in ubiquitin-proteasomal protein degradation. Disheveled proteins (Dvl1 [disheveled 1], Dvl2, and Dvl3) are main components of Wnt/β-catenin signaling pathway, which involved cardiac hypertrophy. aim this study was examine during development Thoracic transverse aortic constriction (TAC) performed transgenic mice with cardiac-specific overexpression (ITCH-Tg) wild-type...