A5036439213- Amyloidosis: Diagnosis, Treatment, Outcomes
- Heart Failure Treatment and Management
- Cardiac Health and Mental Health
- Peptidase Inhibition and Analysis
- Eosinophilic Disorders and Syndromes
- Parathyroid Disorders and Treatments
- Cardiovascular Function and Risk Factors
- Pulmonary Hypertension Research and Treatments
- Palliative Care and End-of-Life Issues
- Cardiac Fibrosis and Remodeling
- Cardiac Imaging and Diagnostics
- Patient-Provider Communication in Healthcare
- Long-Term Effects of COVID-19
- Cardiac Valve Diseases and Treatments
- Ferroptosis and cancer prognosis
- Congenital Heart Disease Studies
- Macrophage Migration Inhibitory Factor
- Antiplatelet Therapy and Cardiovascular Diseases
- Galectins and Cancer Biology
- COVID-19 Clinical Research Studies
- Mechanical Circulatory Support Devices
- Family and Patient Care in Intensive Care Units
- Medication Adherence and Compliance
- Eicosanoids and Hypertension Pharmacology
- Metabolomics and Mass Spectrometry Studies
Keio University
2017-2025
Stanford University
2025
Cardiovascular Institute of the South
2025
Keio University Hospital
2020-2023
Nanjing Medical University
2018
Jiangsu Province Hospital
2018
Mita Hospital
2014-2015
Both osteopontin (OPN) and galectin-3 have been implicated in phagocytic clearance of dead cells reparative fibrosis during wound healing. CD206+ macrophages are involved tissue repair through phagocytosis after myocardial infarction (MI). However, the relationship among OPN, galectin-3, macrophage polarization context MI remains unclear.The time course Spp1 (encoding OPN) expression heart showed a strong activation on day 3 MI. To identify where body which transcriptional activity increased...
The pathogenesis of heart failure with preserved ejection fraction (HFpEF) in obese diabetic patients has been implicated metainflammation. Increased expression inducible nitric oxide synthase (iNOS) and dysfunction the unfolded protein response (UPR), especially inositol-requiring enzyme 1α-X-box binding 1 (IRE1α-Xbp1s) signaling heart, have associated HFpEF. We investigated effect imeglimin, a potential new treatment for type 2 diabetes, on induced obesity, impaired glucose tolerance,...
Neutrophil extracellular traps (NETs) contribute to inflammatory pathogenesis in numerous conditions, including infectious and cardiovascular diseases, have attracted attention as potential therapeutic targets. H2 acts an antioxidant has been clinically experimentally proven ameliorate inflammation. This study was performed investigate whether could inhibit NET formation excessive neutrophil activation. Neutrophils isolated from the blood of healthy volunteers were stimulated with...
The membrane components of cardiomyocytes are rich in polyunsaturated fatty acids, which easily oxidized. Thus, an efficient glutathione-based lipid redox system is essential for maintaining cellular functions. However, the relationship between disruption during ischemia-reperfusion (IR), oxidized production, and consequent cell death (ferroptosis) remains unclear. We investigated mechanisms underlying glutathione-mediated reduction related to ferroptosis IR developed intervention strategies...
Importance The integration of patient-reported outcome (PRO) assessments in cardiovascular care has encountered considerable obstacles despite their established clinical relevance. Objective To assess the impact a physician- and patient-friendly electronic PRO (ePRO) monitoring system on quality practice. Design, Setting, Participants This open-label, multicenter, pilot randomized trial was phase 2 multiphase study that conducted from October 2022 to 2023 focused implementation evaluation an...
Background Although 30-day readmission is thought to be an important quality indicator in patients with hospitalized heart failure, its prognostic impact and comparison of who were readmitted beyond 30 days has not been investigated. We assessed early (0-30 days) versus midrange (31-90 terms incidence distribution, elucidated whether the timing could have a different significance. Methods Results examined failure registered WET-HF (West Tokyo Heart Failure) registry. The primary outcomes...
Background We previously reported that osteopontin plays an essential role in accelerating both reparative fibrosis and clearance of dead cells (efferocytosis) during tissue repair after myocardial infarction (MI) galectin-3hiCD206+ macrophages is the main source post-MI heart. Interleukin-10- STAT3 (signal transducer activator transcription 3)-galectin-3 axis for Spp1 (encoding osteopontin) transcriptional activation cardiac MI. Here, we investigated more detailed mechanism responsible...
Background: This prospective multicenter study assessed the prevalence of myocardial injury in patients with COVID-19 using cardiac magnetic resonance imaging (CMR).
Abstract To extend life expectancy and ensure healthy aging, it is crucial to prevent minimize age‐induced skeletal muscle atrophy, also known as sarcopenia. However, the disease's molecular mechanism remains unclear. The age‐related Wnt/β‐catenin signaling pathway has been recently shown be activated by (pro)renin receptor ((P)RR). We report here that (P)RR expression was increased in atrophied muscles of aged mice humans. Therefore, we developed a gain‐of‐function model sarcopenia via...
Drinking hydrogen (H2)-rich water is a common way to consume H2. Although many studies have shown efficacy of drinking H2-rich in neuropsychiatric and endocrine metabolic disorders, their authenticity has been questioned because none examined the associated pharmacokinetics Therefore, we performed first study investigate H2 pigs given an glucose solution with aim extrapolate findings humans. We inserted blood collection catheters into jejunal portal veins, suprahepatic inferior vena cava,...
Abstract Pulmonary hypertension is a fatal rare disease that causes right heart failure by elevated pulmonary arterial resistance. There an unmet medical need for the development of therapeutics focusing on vascular remodeling. Bioactive lipids produced perivascular inflammatory cells might modulate Here, we show ω-3 fatty acid-derived epoxides (ω-3 epoxides) released from mast PAF-AH2, oxidized phospholipid-selective phospholipase A2, negatively regulate hypertension. Genetic deletion...
Abstract Aims Early engagement in advance care planning (ACP) is recommended heart failure (HF) management. We investigated the preferences of patients with HF regarding ACP and end‐of‐life (EOL) care, including their desired timing initiation. Methods results Data were collected using a 92‐item questionnaire survey, which was directly distributed to hospitalized by dedicated physicians nurses university hospital setting. One‐hundred eighty‐seven agreed participate (response rate: 92.6%),...
Plasma aldosterone concentration increases in proportion to the severity of heart failure, even during treatment with renin-angiotensin system inhibitors. This study investigated alternative regulatory mechanisms production that are significant failure. Dahl salt-sensitive rats on a high-salt diet, rat model failure cardio-renal syndrome, had high plasma levels and elevated β3-adrenergic receptor expression hypoxic zona glomerulosa cells. In H295R cells (a human adrenocortical cell line),...
Abstract Aims Transcatheter aortic valvular replacement (TAVR) is increasingly being performed for elderly patients with stenosis (AS), and current guidelines acknowledge the importance of shared decision‐making in their management. This study aimed to evaluate symptomatic severe AS patients' perspectives on treatment goals identify factors that influence choice. Methods Results We a pre‐procedural cross‐sectional survey using questionnaire at single university hospital. The included three...
Objective To assess patient perspectives on secondary lifestyle modification and knowledge of ‘heart attack’ after percutaneous coronary intervention (PCI) for artery disease (CAD). Design Observational cross-sectional study. Setting A single university-based hospital centre in Japan. Participants In total, 236 consecutive patients with CAD who underwent PCI completed a questionnaire (age, 67.4±10.1 years; women, 14.8%; elective PCI, 75.4%). The survey included questions related to...