A5051075982- Zebrafish Biomedical Research Applications
- Congenital heart defects research
- Angiogenesis and VEGF in Cancer
- Axon Guidance and Neuronal Signaling
- Cellular transport and secretion
- Muscle Physiology and Disorders
- Cardiomyopathy and Myosin Studies
- Retinal Development and Disorders
- Planarian Biology and Electrostimulation
- Cancer, Hypoxia, and Metabolism
- Comparative Animal Anatomy Studies
- Protist diversity and phylogeny
- Fish biology, ecology, and behavior
- PI3K/AKT/mTOR signaling in cancer
- Fish Ecology and Management Studies
- Cardiovascular Effects of Exercise
- Plant Molecular Biology Research
- Marine Ecology and Invasive Species
- Microbial Community Ecology and Physiology
- Lymphatic System and Diseases
- Cephalopods and Marine Biology
- Developmental Biology and Gene Regulation
- Aquaculture disease management and microbiota
- Glycosylation and Glycoproteins Research
- Pregnancy and preeclampsia studies
Kanagawa University
2019-2024
National Institutes of Health
2009-2024
Organogenesis (United States)
2024
Toyo University
2021
Tokyo Institute of Technology
2006-2011
Eunice Kennedy Shriver National Institute of Child Health and Human Development
2011
The cranial vasculature is essential for the survival and development of central nervous system important in stroke other brain pathologies. Cranial vessels form a reproducible evolutionarily conserved manner, but process by which these assemble acquire their stereotypic patterning remains unclear. Here, we examine stepwise assembly vascular network zebrafish hindbrain. major artery supplying hindbrain, basilar artery, runs along ventral keel hindbrain all vertebrates. We show that this...
Versican is an evolutionary conserved extracellular matrix proteoglycan, and versican expression loss in mice results embryonic lethality owing to cardiovascular defects. However, the utero development of mammals limits our understanding precise role during development. Therefore, use evolutionarily distant species that develop ex more suitable for studying mechanistic basis activity. We performed ENU mutagenesis screening identify medaka mutants with defects In this study, we described a...
Abstract The zebrafish has become a very useful vertebrate model for cardiovascular research, but detailed morphogenetic studies have revealed that it differs from mammals in certain aspects of the primary circulatory system, particular, early vitelline circulation. We searched another teleost species might serve as complementary formation these vessels. Here (and online at http://www.shigen.nig.ac.jp/medaka/atlas/ ), we present characterization vascular anatomy developing medaka embryo...
Urodeles and fish have higher regeneration ability in a variety of tissues organs than do other vertebrate species including mammals. Though many studies aimed at identifying the cellular molecular basis for regeneration, relatively little is known about detailed behaviors involved basis. In present study, small molecule inhibitor was used to analyzed role phosphoinositide 3‐kinase (PI3K) signaling during regeneration. We showed that disrupted formation blastema expression characteristic...
Abstract Angiogenesis is essential for the normal development of an embryo. Silver nanocolloid (SNC) known to induce vascular malformation in medaka We focused on central arteries (CtAs) hindbrain Japanese medaka. The CtAs and basilar artery from which they branch are transporting blood nutrients necessary support parenchyma pons cerebellum hindbrain. exposed embryos at developmental stage 21 (6 somite stage), 0, 0.5, 5, or 10 mg/L SNC evaluated hatching rate, number thrombi per embryo, head...
ABSTRACT Dynein cytoplasmic 1 light intermediate chain (LIC1, DYNC1LI1 ) is a core subunit of the dynein motor complex. The LIC1 also interacts with various cargo adaptors to regulate Rab-mediated endosomal recycling and lysosomal degradation. Defects in this gene are predicted alter function, Rab binding capabilities, trafficking. Here, we have identified dync1li1 zebrafish mutant, harboring premature stop codon at exon 12/13 splice acceptor site, that displays increased angiogenesis. In...
Progress in protein labeling by gene fusion with fluorescent protein-encoding genes and microscopic apparatuses, such as a confocal laser-scanning microscope, has enabled time-lapse analysis of meiotic chromosome movement living plant cells. Here, we constructed the pAtDMC1:H2B:GFP introduced it into Arabidopsis thaliana. Whole-genome sequencing confirmed insertion locus between AT3G14830 AT3G14840. The expression was not specific to meiocytes but significant pollen mother cells (PMCs)...