A5066886576- Cardiovascular Health and Disease Prevention
- Blood Pressure and Hypertension Studies
- Dialysis and Renal Disease Management
- Parathyroid Disorders and Treatments
- Renal function and acid-base balance
- Chronic Kidney Disease and Diabetes
- Cerebrovascular and Carotid Artery Diseases
- Cardiovascular Function and Risk Factors
- Heart Rate Variability and Autonomic Control
- Renal and Vascular Pathologies
- Hemodynamic Monitoring and Therapy
- Hormonal Regulation and Hypertension
- Cardiovascular Disease and Adiposity
- Non-Invasive Vital Sign Monitoring
- Adrenal and Paraganglionic Tumors
- Cardiac Imaging and Diagnostics
- Vitamin D Research Studies
- Peripheral Artery Disease Management
- Bone health and osteoporosis research
- Renal Transplantation Outcomes and Treatments
- Organ Transplantation Techniques and Outcomes
- Renin-Angiotensin System Studies
- MRI in cancer diagnosis
- Advanced MRI Techniques and Applications
- Lipoproteins and Cardiovascular Health
Université Laval
2016-2025
Hôtel-Dieu de Québec
2015-2024
Centre hospitalier universitaire de Québec
2008-2024
Université de Montréal
2000-2023
Hôpital du Sacré-Cœur de Montréal
2018-2023
University of Oxford
2023
Quebec Research and Development Centre
2016-2021
Centre hospitalier de l'Université Laval
2016-2021
Université du Québec à Montréal
2018
Hôpital Maisonneuve-Rosemont
2000-2018
Sodium-glucose co-transporter-2 (SGLT2) inhibitors reduce progression of chronic kidney disease and the risk cardiovascular morbidity mortality in a wide range patients. However, their effects on some patients with are unclear because few clinical outcomes occurred among such completed trials. In particular, guidelines stratify level recommendation about who should be treated SGLT2 based diabetes status albuminuria. We aimed to assess empagliflozin both overall specific types participants...
BACKGROUND Vascular calcification, a regulated process in chronic kidney disease (CKD), requires vascular smooth muscle cell (VSMC) differentiation into osteoblast-like cells. This phenomenon can be enhanced by inflammatory cytokines and production of reactive oxygen species (ROS). In CKD rats with we investigated whether cytokines, ROS generation, downstream signaling events are associated CKD-related calcification. METHODS was induced male Wistar renal mass ablation calcification high...
We hypothesized that increased aortic stiffness (central elastic artery) combined with a decrease in brachial (peripheral muscular leads to the reversal of physiological gradient (ie, mismatch), promoting end-organ damages through forward pressure wave transmission into microcirculation. We, therefore, examined effect aortic-brachial mismatch on mortality patients need dialysis. In prospective observational study, arterial (pulse velocity ratio) was assessed using carotid-femoral pulse...
The EMPA-KIDNEY trial showed that empagliflozin reduced the risk of primary composite outcome kidney disease progression or cardiovascular death in patients with chronic mainly through slowing progression. We aimed to assess how effects might differ by across its broad population.
We investigate the role of transforming growth factor-beta (TGF-beta) in hypertension and renal failure progression uremic rats, whether it modulates endothelin (ET) system.Following mass reduction, rats (Nx) received pan-specific TGF-beta neutralizing antibody 1D11 (0.5 mg/kg, three times/week), isotype control 13C4 or AT1 antagonist losartan (10 mg/kg per day) for 6 weeks.Before treatment, blood pressure was higher Nx increased further over time Nx+13C4 rats. At end study, exhibited serum...
Aortic stiffness is associated with increased cardiovascular mortality in patients chronic kidney disease. However, the rate of progression arterial and role risk factors has never been established a longitudinal study. In prospective, longitudinal, observational study, carotid-femoral pulse wave velocity carotid-radial were assessed 109 hemodialysis at baseline after mean follow-up 1.2 years. We examined impact age, atherosclerotic disease, diabetes mellitus, dialysis vintage, pentosidine...
Primary aldosteronism is a common, yet highly underdiagnosed, cause of hypertension that leads to disproportionately high rates cardiovascular disease. Hypertension plus hypokalemia guideline-recommended indication screen for primary aldosteronism, the uptake this recommendation at population level remains unknown. We performed population-based retrospective cohort study adults ≥18 years old in Ontario, Canada, with (potassium <3.5 mEq/L) from 2009 2015 follow-up through 2017. measured...
Primary aldosteronism, characterized by overt renin-independent aldosterone production, is a common but underrecognized form of hypertension and cardiovascular disease. Growing evidence suggests that milder subclinical forms primary aldosteronism are highly prevalent, yet their contribution to disease not well characterized.
Abstract —This prospective study was designed to compare the captopril suppression test with salt-loading approach confirm diagnosis of primary aldosteronism. A total 49 patients were referred a presumed The performed in morning seated position after overnight fasting. Blood samples for plasma aldosterone obtained before administration (25 mg PO) and again 2 hours later. Patients then subjected high salt diet (300 mmol sodium per day 3 days). On third day, urinary (24 hours) measured, levels...
Exposure to urban air pollution, ultrafine particles or gases, is associated with acute cardiovascular mortality and morbidity. We investigated the effect of ambient pollution on endothelial function in 40 healthy white male nonsmokers spontaneously breathing Paris, France. Air pollutant levels (nitrogen, sulfur carbon oxides, particulate matter) were averaged during 5 days preceding arterial measurements. Brachial artery endothelium-dependent flow-mediated dilatation reactive hyperemia...
<b><i>Background:</i></b> Increased production of tumor necrosis factor-α (TNF-α) in chronic kidney disease may be involved the progression renal failure and injury, cardiovascular disease. We investigated effect TNF-α neutralization on failure, inflammation fibrosis, blood pressure rats with failure. <b><i>Methods Results:</i></b> Renal was induced by mass reduction animals were treated PEG-sTNFR1, a pegylated form soluble TNF type 1 receptor...
Vascular remodeling diseases (VRD) are mainly characterized by inflammation and a vascular smooth muscle cells (VSMCs) proproliferative anti-apoptotic phenotype. Recently, the activation of advanced glycation endproducts receptor (RAGE) has been shown to promote VSMC proliferation resistance apoptosis in VRD signal transducer activator transcription (STAT)3-dependant manner. Interestingly, we previously described both cancer that sustainability this antiapoptotic phenotype requires factor...
Background: Cardiovascular disease is the most common cause of death in patients with chronic kidney (CKD). Arterial stiffness and calcification are non-traditional risk factors cardiovascular CKD. In CKD rats, we investigated involvement smooth muscle cells differentiation to osteoblast-like blood vessel wall remodeling, associated media calcification, arterial stiffness.Method: vascular was induced by subtotal nephrectomy followed treatment a high calcium phosphate diet, vitamin D...
Aortic stiffness, a cardiovascular risk factor, depends on the operating mean arterial pressure (MAP). The impact of aortic stiffness outcomes is proposed to be mediated by attenuation or reversal gradient. We hypothesized that gradient less influenced changes in MAP. aimed study relationship between MAP and brachial In cross-sectional dialysis cohort (group A, n=304) hypertensive kidney transplant recipient with an estimated glomerular filtration rate >45 mL/min/1.73 m 2 B, n=114), we...
<h3>Importance</h3> Glomerular hyperfiltration is associated with increased risk of cardiovascular disease in high-risk conditions, but its significance low-risk individuals uncertain. <h3>Objective</h3> To determine whether glomerular healthy individuals. <h3>Design, Setting, and Participants</h3> This was a prospective population-based cohort study, for which enrollment took place from August 2009 to October 2010, follow-up available through March 31, 2016. Analysis the data 2019. The...
Compared with brachial blood pressure (BP), central systolic BP (SBP) can provide a better indication of the hemodynamic strain inflicted on target organs, but it is unclear whether this translates into improved cardiovascular risk stratification. We aimed to assess which or best predicts and identify SBP threshold associated increased future events. This study included 13 461 participants CARTaGENE available follow-up data from administrative databases without disease antihypertensive...
Aortic stiffness, assessed through carotid-femoral pulse wave velocity (PWV), has been associated with an increased risk of cardiovascular events and mortality. Measurements PWV are based on the proper identification foot waveform by either maximum second-derivative method (as used in Complior) or intersecting tangents algorithms SphygmoCor). These approaches can give different results, especially at higher ranges. However, these devices also differ signal acquisition technology, filtering,...
Glomerular filtration decreases progressively with age in adults. Predictive equation should have proper modelling to adequately account for normal senescence.Corrected 24-h creatinine clearances (CCLs) were measured a cohort of 773 outpatients from 18 90 years old. Multiple linear regression was used model the effect on glomerular filtration. Comparisons made simplified MDRD and MAYO equations. Impact derived tested second 7551 patients serum creatinine.While all equations show declining...
Newer biomarkers, reflective of biological processes, such as inflammation and fibrosis, cardiac stretch or damage vascular health may be useful in understanding clinical events chronic kidney disease (CKD). We assessed whether these newer alone a panel, improve risk prediction for renal replacement therapy death, over above conventional clinical, demographic laboratory variables. conducted prospective observational Canadian cohort study 2544 CKD patients with estimated glomerular filtration...
Accelerated progression of aortic stiffness in patients with advanced chronic kidney disease is not well explained by the traditional cardiovascular risk factors. We hypothesized that vitamin K deficiency may result an accelerated pro-calcifying uremic milieu. Eighteen hemodialysis (HD) on warfarin were matched to 54 HD without (control). Aortic was determined carotid-femoral pulse wave velocity (cf-PWV) at baseline and after a mean follow-up 1.2 years. In control group, spontaneous defined...
Central (aortic) systolic blood pressure (cSBP) is the seen by heart, brain, and kidneys. If properly measured, cSBP closer associated with hypertension-mediated organ damage prognosis, as compared brachial SBP (bSBP). We investigated 24-hour profiles of bSBP cSBP, measured simultaneously using Mobilograph devices, in 2423 untreated adults (1275 women; age, 18–94 years), free from overt cardiovascular disease, aiming to develop reference values analyze daytime-nighttime variability. was...