A5021248743- Diabetes, Cardiovascular Risks, and Lipoproteins
- Prostate Cancer Treatment and Research
- Ovarian cancer diagnosis and treatment
- Hormonal Regulation and Hypertension
- Lipoproteins and Cardiovascular Health
- Cancer, Lipids, and Metabolism
- Prostate Cancer Diagnosis and Treatment
- Parathyroid Disorders and Treatments
- Bone health and osteoporosis research
- Vitamin D Research Studies
- Renal function and acid-base balance
- Cancer-related molecular mechanisms research
- Sexual Differentiation and Disorders
- Cardiovascular Health and Disease Prevention
- Adrenal and Paraganglionic Tumors
- Lung Cancer Research Studies
- Poisoning and overdose treatments
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Organ Transplantation Techniques and Outcomes
- Bone health and treatments
- Lipid metabolism and disorders
- Head and Neck Cancer Studies
- Hepatitis B Virus Studies
- Statistical Methods in Clinical Trials
- BRCA gene mutations in cancer
Université Laval
2012-2024
Centre hospitalier universitaire de Québec
1998-2024
Centre hospitalier de l'Université Laval
2024
Hôtel-Dieu de Québec
2002-2022
Institut Universitaire de Cardiologie et de Pneumologie de Québec
2018
Montreal Heart Institute
2018
Ontario Institute for Cancer Research
2010
Princess Margaret Cancer Centre
2010
Park Nicollet Clinic
1989
Hôpital Saint-François d'Assise
1987
Abstract Randomized trials have shown, unexpectedly, that supplementation with selenium or vitamin E is associated a reduction of prostate cancer risk. We assess whether low doses antioxidant vitamins and minerals could reduce the occurrence influence biochemical markers. The SU.VI.MAX trial comprised 5,141 men randomized to take either placebo nutritional C, E, β‐carotene, zinc daily for 8 years. Biochemical markers risk such as prostate‐specific antigen (PSA) insulin‐like growth factors...
Abstract —This prospective study was designed to compare the captopril suppression test with salt-loading approach confirm diagnosis of primary aldosteronism. A total 49 patients were referred a presumed The performed in morning seated position after overnight fasting. Blood samples for plasma aldosterone obtained before administration (25 mg PO) and again 2 hours later. Patients then subjected high salt diet (300 mmol sodium per day 3 days). On third day, urinary (24 hours) measured, levels...
Glomerular filtration decreases progressively with age in adults. Predictive equation should have proper modelling to adequately account for normal senescence.Corrected 24-h creatinine clearances (CCLs) were measured a cohort of 773 outpatients from 18 90 years old. Multiple linear regression was used model the effect on glomerular filtration. Comparisons made simplified MDRD and MAYO equations. Impact derived tested second 7551 patients serum creatinine.While all equations show declining...
The prognostic relevance of inherited variations in hormone-related genes the context prostate cancer (PCa) progression has not been well studied. Of these, UDP-glucuronosyltransferase (UGT) gene products lead to inactivation steroids.Our objective was determine whether polymorphisms five UGT genes, involved steroid metabolism, are associated with risk biochemical recurrence after radical prostatectomy (RP) and examine their relationship hormonal exposure.The study included 526 Caucasian 320...
Accelerated progression of aortic stiffness in patients with advanced chronic kidney disease is not well explained by the traditional cardiovascular risk factors. We hypothesized that vitamin K deficiency may result an accelerated pro-calcifying uremic milieu. Eighteen hemodialysis (HD) on warfarin were matched to 54 HD without (control). Aortic was determined carotid-femoral pulse wave velocity (cf-PWV) at baseline and after a mean follow-up 1.2 years. In control group, spontaneous defined...
Although most catheter problems in haemodialysis are related to infection or clotting, bleeding associated with the heparin lock is of clinical importance especially during peri-operative conditions. The objective this vitro study estimate volume that may leak into circulation immediately after performing a lock.Different volumes (ml) dextrose solution were used perform on catheters. tip was placed test tube containing water for pre-specified period. final concentrations determine leaked...
Abstract Purpose: Recognized prognostic factors do not adequately predict outcomes of head and neck cancer (HNC) patients after their initial treatment. We identified from the literature nine potential serum markers assessed whether they improve outcome prediction. Experimental Design: A pretreatment sample was obtained 527 540 HNC who participated in a randomized controlled trial. During follow-up, 115 had recurrence, 110 second primary (SPC), 216 died. measured markers: prolactin, soluble...
Background. Abnormal mineral metabolism in chronic kidney disease plays a critical role vascular calcification and arterial stiffness. The impact of presently used dialysis calcium concentration (D Ca ) on stiffness aortic pressure waveform has never been studied. aim the present study is to evaluate, haemodialysis (HD) patients, acute modification D central pulse wave profile (cPWP). Method. A randomized Latin square cross-over was evaluate three different concentrations (1.00, 1.25 1.50...
Low pretreatment vitamin D status has been associated with worsened disease outcomes in patients cancer at various sites. Its prognostic significance head and neck (HNC) not studied. Patients HNC who participated a randomized trial were evaluated for: (i) total intake of from diet supplements using validated food frequency questionnaire (all participants, n = 540) (ii) serum 25-hydroxyvitamin through radioimmunoassay (n 522). The association dietary/serum measures recurrence, second primary...
Background. Higher dialysate calcium (DCa) can result in an acute and transient increase arterial stiffness. The aim of the present study is to evaluate impact DCa on progression stiffness, balance bone metabolism haemodialysis (HD) patients over a 6-month period.
Clinical utility of new biomarkers often requires the identification their optimal threshold. This external validation study was conducted to assess performance preoperative plasma tumor markers HE4 and CA125 cut-offs predict cancer mortality in women with epithelial ovarian (EOC). Participating had upfront debulking surgery University Hospital Quebec City (Canada) between 1998 2013. A total 136 participated training cohort (cohort 1) 177 2). Preoperative levels were measured by Elecsys....
Abstract Cancer cells need constant supplies of lipids to survive and grow. Lipid dependence has been observed in various types cancer, including high-grade serous ovarian carcinomas (HGSOC), which is a lethal form gynecological malignancy. ANGPTL3, PCSK9, Apo CIII are pivotal lipid-modulating factors, therapeutic antibodies have developed against each one (Evinacumab, Evolocumab Volanesorsen, respectively). The roles -if any- HGSOC unclear. Moreover, levels these factors never reported...