A5047832933- Epigenetics and DNA Methylation
- Cancer Cells and Metastasis
- Cancer Genomics and Diagnostics
- Asthma and respiratory diseases
- Lung Cancer Treatments and Mutations
- Head and Neck Cancer Studies
- Cancer-related gene regulation
- Cancer Diagnosis and Treatment
- Sinusitis and nasal conditions
- Tracheal and airway disorders
- Cancer Immunotherapy and Biomarkers
- Salivary Gland Tumors Diagnosis and Treatment
- Allergic Rhinitis and Sensitization
- MicroRNA in disease regulation
- Immune cells in cancer
- RNA Interference and Gene Delivery
- Mass Spectrometry Techniques and Applications
- Drug-Induced Adverse Reactions
- Neuroendocrine Tumor Research Advances
- Oral and Maxillofacial Pathology
- Immune Cell Function and Interaction
- Histone Deacetylase Inhibitors Research
- Ear Surgery and Otitis Media
- PI3K/AKT/mTOR signaling in cancer
- Cervical Cancer and HPV Research
University of Yamanashi
2013-2024
Showa University Hospital
2024
Showa University East Hospital
2024
Showa University
2024
National Institutes of Health
2017-2023
Cancer Genetics (United States)
2023
Center for Cancer Research
2017-2023
GTx (United States)
2022
National Cancer Institute
2017-2020
National Institute of Neurological Disorders and Stroke
2017
ESRP1 (epithelial splicing regulatory protein 1) and ESRP2 regulate alternative events associated with epithelial phenotypes of cells, both are down-regulated during the epithelial-mesenchymal transition. However, little is known about their expression functions carcinogenesis. In this study, we found that plastic: oral squamous cell carcinogenesis, these proteins up-regulated relative to levels in normal epithelium but invasive fronts. Importantly, re-expressed lymph nodes, where carcinoma...
Abstract Abnormal DNA methylation at the C‐5 position of cytosine (5mC) CpG dinucleotides is a well‐known epigenetic feature cancer. Levels E‐cadherin, which regularly expressed in epithelial tissues, are frequently reduced tumors due to transcriptional repression, sometimes accompanied by hypermethylation promoter region. δ EF1 family proteins ( / ZEB1 and SIP1 ZEB2 ), key regulators epithelial‐mesenchymal transition EMT suppress E‐cadherin expression level. We recently showed that levels...
Snail, also called Snai1, is a key regulator of EMT. Snail plays crucial roles in cancer progression, including resistance to anti-tumor drugs and invasion by various cells. Slug, known as Snai2, involved the aggravation certain tumors. In this study, we examined Slug human oral squamous cell carcinoma (OSCC) highly expressed these cells, siRNA effectively represses drug invasive properties. addition, transforming growth factor (TGF)-β upregulates expression promotes OSCC Surprisingly,...
CD44 was identified previously as a surface marker in cancer stem cells (CSCs) of head and neck squamous cell carcinoma (HNSCC). Most treatments have been linked to the activation apoptosis-signaling pathway; however, resistance mechanisms apoptosis CSCs not yet fully elucidated.The sensitivity CD44+ diverse apoptosis-inducing stimuli compared with that CD44- cells. Furthermore, cycle changes expression anti-apoptosis-related genes were examined using flow cytometry real-time quantitative...
Recent progression in the understanding of stem cell biology has greatly facilitated identification and characterization cancer cells ( CSC s). Moreover, evidence accumulated indicating that conventional treatments are potentially ineffective against CSCs . Histone deacetylase inhibitors HDAC i) have multiple biologic effects consequent to alterations patterns acetylation histones a promising new group anticancer agents. In this study, we investigated two i, suberoylanilide hydroxamic acid...
Current cancer treatments are largely based on the genetic characterization of primary tumors and ineffective for metastatic disease. Here we report that DNA methyltransferase 3B (DNMT3B) is induced at distant sites mediates epigenetic reprogramming tumor cells. Multiomics analysis spontaneous mouse models revealed DNMT3B alters multiple pathways including STAT3, NFκB, PI3K/Akt, β-catenin, Notch signaling, which critical cell survival, apoptosis, proliferation, invasion, colonization. PGE2...
Abstract ETS homologous factor (EHF) belongs to the epithelium-specific subfamily of E26 transformation-specific (ETS) transcription family. Currently, little is known about EHF’s function in cancer. We previously reported that ETS1 induces expression ZEB family proteins ZEB1/δEF1 and ZEB2/SIP1, which are key regulators epithelial–mesenchymal transition (EMT), by activating ZEB1 promoters. have found EHF gene produces two transcript variants, namely a long form variant includes exon 1...
Tumor-derived soluble factors promote the production of Gr-1+CD11b+ immature myeloid cells, and TGFβ signaling is critical in their immune suppressive function. Here, we report that miR-130a miR-145 directly target receptor II (TβRII) are down-regulated these leading to increased TβRII. Ectopic expression cells decreased tumor metastasis. This mediated through a downregulation type 2 cytokines an increase IFNγ-producing cytotoxic CD8 T lymphocytes. miR-130a- miR-145-targeted molecular...
Chronic rhinosinusitis (CRS), which is clinically classified into CRS without nasal polyps (CRSsNP) and with (CRSwNP), shows considerable geographic differences heterogeneity. Eosinophilic (E) (ECRSwNP) has a higher degree of disease severity frequency comorbid asthma. Epidemiologic studies in different ethnic populations have improved understanding the pathophysiology disease. Here we report clinical characteristics Japanese patients medically refractory undergoing endoscopic sinus surgery...
Cryptogenic strokes, those of unknown cause, have been estimated as high 30% to 40% strokes. Inflammation has suggested a critical etiologic factor. However, there is lack experimental evidence.In this study, we investigated inflammation-associated stroke using mouse model that developed spontaneous because myeloid deficiency TGF-β (transforming growth factor-β) signaling.We report mice with deletion Tgfbr2 in cells (Tgfbr2Myeko) cerebrovascular inflammation the absence significant pathology...
Constipation is a prevalent gastrointestinal disorder that affects people globally, decreasing their quality of life and expectancy. Individuals with schizophrenia often suffer from constipation, which could be result the illness itself or side effects psychotropic medications. However, little research has been conducted on factors contributing to constipation in individuals schizophrenia. To address this issue, we survey using self-administered questionnaires medical records identify...
A randomized Phase II selection design trial comparing gemcitabine plus S-1 combination therapy with monotherapy for chemo-naïve unresectable or recurrent biliary tract cancer patients was started in Japan. The aim of this is to evaluate the efficacy and safety two regimens determine which more promising as a test arm regimen be compared current standard regimen, cisplatin, subsequent III trial. Patients are either arm. total 100 will accrued study from 18 institutions over 1 year. primary...
Abstract Background Several pro-oncogenic signals, including transforming growth factor beta (TGF-β) signalling from tumour microenvironment, generate intratumoural phenotypic heterogeneity and result in progression treatment failure. However, the precise diagnosis for areas containing subclones with cytokine-induced malignant properties remains clinically challenging. Methods We established a rapid diagnostic system based on combination of probe electrospray ionisation-mass spectrometry...
The mechanisms of how cancer cells are selected and evolve to establish distant metastatic colonies remain unclear. Tumor heterogeneity lack biomarkers some the most difficult challenges in biology treatment. Here using mouse models for triple-negative breast (TNBC) metastasis, we report heterogeneous expression DNA methyltransferase 3B (DNMT3B) both human primary tumors. High levels DNMT3B were correlated with poor clinical outcomes multiple datasets. Mechanistically, clonal high (DNMT3BH)...
The lack of available tumor antigens with strong immunogenicity, human leukocyte antigen restriction, and immunosuppression via regulatory T-cells (Tregs) myeloid-derived suppressor cells are limitations for dendritic cell (DC)–based immunotherapy in patients advanced head neck cancer (HNC). We sought to overcome these induce effective antitumor immunity the host. effect low-dose docetaxel (DTX) treatment on DC maturation was examined an ex vivo study, a phase I clinical trial combination...
Cancer immunotherapy is one of the new prospective treatments for head and neck squamous cell carcinoma (HNSCC). This strategy can effectively induce anti-tumor effects. However, despite surveillance by host immune system, tumor cells develop acquire malignant phenotypes, example, invasion into stromal tissue, metastasis to lymph nodes distant organs. Tumors with oncogenic mutations cellular heterogeneity actively suppress system assistance from microenvironment, including regulatory T...
Abstract Background The purpose of this study was to evaluate the association between immunohistochemistry (IHC) protein tyrosine kinase 7 (PTK7) expression and clinicopathological factors oral squamous cell carcinoma (OSCC). Methods Tissue specimens were obtained from 80 patients with primary OSCC. IHC scoring conducted according rate positive staining intensity. We used score classify degree PTK7 prognosis. Results number high group (IHC Score 2 or 3) 45 cases that low 0 1) 35 cases. A...
Metastatic intrathyroid thymic carcinoma (ITTC) is a rare cancer with no effective drugs for controlling. This case report has shown genomic and immune microenvironment profiles in metastatic ITTC emphasized an immunosuppression via PD-1/PD-L1 pathway, possibly strengthening the rationale checkpoint blockade as novel treatment.
Abstract Hypersensitivity reaction to cisplatin can result in discontinuation of chemoradiotherapy patients with head and neck squamous cell carcinoma. We describe a patient nasopharyngeal carcinoma who developed hypersensitivity was successfully treated desensitization. Furthermore, it had little impact on the therapeutic performance cisplatin‐combined chemoradiotherapy.