A5027407781- Heart Rate Variability and Autonomic Control
- Adipose Tissue and Metabolism
- Diet and metabolism studies
- Blood Pressure and Hypertension Studies
- Neonatal Respiratory Health Research
- Cardiovascular Disease and Adiposity
- Muscle metabolism and nutrition
- Neuroscience of respiration and sleep
- Cardiac Arrest and Resuscitation
- Exercise and Physiological Responses
- Nutritional Studies and Diet
- Gut microbiota and health
- Cardiovascular Syncope and Autonomic Disorders
- Innovations in Medical Education
- Neuropeptides and Animal Physiology
- Vagus Nerve Stimulation Research
- Cardiovascular Health and Disease Prevention
- Cardiovascular and exercise physiology
- Airway Management and Intubation Techniques
- Liver Disease Diagnosis and Treatment
- Preterm Birth and Chorioamnionitis
- Regulation of Appetite and Obesity
- Regional Socio-Economic Development Trends
- Cancer, Stress, Anesthesia, and Immune Response
- Interprofessional Education and Collaboration
Swinburne University of Technology
2017-2023
Baker Heart and Diabetes Institute
2015-2023
Centre for Nursing Innovation
2019
University College London
2016-2018
University College London Hospitals NHS Foundation Trust
2018
Queen Victoria Hospital
2017
University College Hospital
2016
University of Mississippi
2016
Royal Liverpool University Hospital
2015
University of Liverpool
2015
High blood pressure (BP) continues to be a major, poorly controlled but modifiable risk factor for cardiovascular death. Among key Western lifestyle factors, diet poor in fiber is associated with prevalence of high BP. The impact lack prebiotic and the mechanisms that lead higher BP are unknown. Here we show dietary leads development hypertensinogenic gut microbiota, hypertension its complications, demonstrate role G-protein coupled-receptors (GPCRs) sense metabolites.One hundred...
Beta-adrenergic blockade has been associated with improved cancer survival in patients triple-negative breast (TNBC), but the mechanisms of these effects remain unclear. In clinical epidemiological analyses, we identified a relationship between beta-blocker use and anthracycline chemotherapy protecting against TNBC progression, disease recurrence, mortality. We recapitulated effect beta-blockade on efficacy xenograft mouse models TNBC. metastatic 4T1.2 MDA-MB-231 TNBC, doxorubicin by...
Summary Objective Polycystic ovary syndrome ( PCOS ) is associated with increased obesity a greater propensity to weight gain and lack of sustainable lifestyle interventions. Altered brown adipose tissue BAT thermogenesis potential contributor in . activity modulation have not been studied This observational study explored its associations women without Participants methods Cutaneous temperature was recorded from supraclavicular (indicator activity) upper arm regions using dataloggers...
Both exercise and breaks in prolonged sitting can reduce blood pressure (BP) older overweight/obese adults. We investigated whether there is an additive hypotensive effect when combined with subsequent sitting. Sex differences changes plasma catecholamines as a potential candidate mechanism underlying BP responses were also examined. Sedentary adults (n=67; 67±7 years; 31.2±4.1 kg/m 2 ) completed 3 conditions random order—sitting (SIT): uninterrupted (8 hours, control); exercise+sitting...
Background and Purpose: Elevated sympathetic nervous system (SNS) activity is a characteristic of obesity type 2 diabetes (T2D) that contributes to target organ damage cardiovascular risk. In this study we examined whether baseline metabolic status influences the degree sympathoinhibition attained following equivalent dietary weight loss. Methods: Un-medicated obese individuals categorized as normal glucose tolerant (NGT, n=15), impaired (IGT, n=24) newly-diagnosed T2D (n=15) consumed...
The present study assessed the effects of a diet and exercise intervention in jockeys on body composition, metabolism, bone mental health. 10 followed an individually prescribed 6-wk (Carbohydrate=2.5–3.5 g/kg, Protein=2.5 Fat=1.0 g/kg). Body mass (59.2±4.6 vs. 57.6±4.5 kg), fat (7.5±3.5 6.2±2.6) (13.1±5.9 11.5±4.9%) all decreased (P<0.05) from pre to post-intervention whilst lean (47.1±5.3 47.0±5.5 kg) was maintained (P=0.80). RMR (1703±329 1975±313 kcal.d<sup>-1</sup>), VO<sub>2max</sub>...
Objective Because sympathetic nervous system activity plays a detrimental role in metabolic and cardiovascular health, this study compared the effects of centrally acting sympatholytic agent, weight loss (WL) program using low‐calorie diet, combination both. Methods Young (18‐30 years) male subjects with overweight (BMI > 25 kg/m 2 ) were allocated to WL ( n = 10), moxonidine treatment course (M; 10, 0.4 mg/d), both (WL + M; 11), or control (C) group 6) for 6 months. Muscle nerve (MSNA),...
Background: A diet rich in fat, particular saturated fat (SF), may be linked to cardiovascular disease development, possibly due a detrimental effect of on endothelial function (EF). Objective: We aimed determine whether the habitual SF intake [as ratio total (the sum saturated, polyunsaturated and monounsaturated fat)] might influence young, overweight but otherwise healthy adults. Design: Sixty-nine young adults (49 males, mean age: 23±1 years, BMI: 29.1±0.8 kg/m2) were classified into...
Impaired insulin clearance contributes to the hyperinsulinemia of obesity, yet relatively little is known concerning pathophysiological determinants in obese populations.To examine cross-sectional relationship between and resting sympathetic nervous system activity a cohort subjects with metabolic syndrome.Unmedicated, nonsmoking (31 male, 27 female; aged 56 ± 1 year; body mass index 33.7 0.6 kg/m(2)) underwent euglycemic hyperinsulinemic clamp determine sensitivity (M) clearance, assessment...
This study tested the hypothesis that varying degrees of hemodynamic fluctuations seen after birth following immediate cord clamping were related to development asphyxia with longer clamp-to-ventilation intervals, resulting in higher perinatal circulating levels catecholamines norepinephrine (NE) and epinephrine (Epi), thus increased heart rate, blood pressures, cardiac contractility birth. Anesthetized preterm fetal lambs instrumented 1) aortic (AoT) pulmonary trunk (PT) micromanometers...
The hyperinsulinemia of obesity is a function both increased pancreatic insulin secretion and decreased clearance, contributes to cardiovascular risk. Whilst weight loss known enhance there paucity data concerning the underlying mechanisms. This study was conducted examine inter-relationships between changes in sympathetic nervous system (SNS) activity, vascular clearance during program. Seventeen non-smoking, un-medicated individuals aged 55 ± 1 years (mean SEM), body mass index (BMI) 33.9...
Controversy exists about the physiological mechanism(s) underlying decreases in cardiac output after immediate clamping of umbilical cord at birth. To define these mechanisms, four major determinants ventricular (afterload, preload, heart rate and contractility) were measured concurrently fetal lambs 15 s intervals over a 2 min period before ventilation following delivery. After clamping, right (but not left) fell by 20% initial 30 s, due to increased afterload associated with higher...
Background: Neck circumference (NC) is a predictor of cardiometabolic risk. The objective this study was to explore the relationship NC muscle sympathetic nerve activity (MSNA) within an overweight and obese population. Methods: design retrospective cross-sectional analysis. Un-medicated persons (72 men, 53 postmenopausal women) aged 56 ± 1 years (mean SEM) with body mass index (BMI) 32.8 0.4 kg/m2, were studied. measured together traditional anthropometric measures, supine blood pressure,...
Asian subjects are at increased cardio-metabolic risk comparatively lower body mass index (BMI) compared with white subjects. Sympathetic nervous system activation and dyslipidemia, both characteristics of adiposity, appear to be related. We therefore analyzed the association muscle sympathetic nerve activity (MSNA) plasma lipidomic profile in young adult Blood samples were collected from 101 participants either or background (age, 18 30 years; BMI, 28.1 ± 5.9 kg/m2). Lipids extracted using...
Pure autonomic failure (PAF) is a rare sporadic disorder characterized by in the absence of movement or dementia and associated with very low plasma norepinephrine (NE) levels-suggesting widespread sympathetic denervation, however due to its rarity pathology remains poorly elucidated. We sought correlate clinical neurochemical findings nerve protein abundances, accessed way forearm vein biopsy, patients PAF healthy controls multiple systems atrophy (MSA) whom nerves are considered intact....