A5087723386- Parasites and Host Interactions
- IL-33, ST2, and ILC Pathways
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Asthma and respiratory diseases
- Child Nutrition and Water Access
- Single-cell and spatial transcriptomics
- Parasite Biology and Host Interactions
- Inhalation and Respiratory Drug Delivery
- Global Maternal and Child Health
- Immune Cell Function and Interaction
- Neonatal Respiratory Health Research
- Immune Response and Inflammation
- Immune cells in cancer
- T-cell and B-cell Immunology
- Dermatology and Skin Diseases
- Heat shock proteins research
- Trace Elements in Health
- Research on Leishmaniasis Studies
- Pediatric health and respiratory diseases
- Lipoproteins and Cardiovascular Health
- Amoebic Infections and Treatments
- Pancreatitis Pathology and Treatment
- Virus-based gene therapy research
- Cardiac Fibrosis and Remodeling
- Eosinophilic Esophagitis
University of Cincinnati Medical Center
2019-2024
University of North Dakota
2021-2024
Cincinnati Children's Hospital Medical Center
2019-2024
University of Cincinnati
2023-2024
Nagasaki University
2014-2020
Children's Medical Center
2020
The University of Tokyo
2015
Osaka University
2015
The dual role of CD8
Background An increasing risk of Schistosoma mansoni infection has been observed around Lake Victoria, western Kenya since the 1970s. Understanding local transmission dynamics schistosomiasis is crucial in curtailing increased infection. Methodology/Principal Findings We carried out a cross sectional study on population 310 children from eight primary schools. Overall, total 238 (76.8%) were infected with S. mansoni, while seven (2.3%) had haematobium. The prevalence hookworm, Trichuris...
Large-scale schistosomiasis control programs are implemented in regions with diverse social and economic environments. A key epidemiological feature of is its small-scale heterogeneity. Locally profiling disease dynamics including risk factors associated transmission essential for designing appropriate programs. To determine spatial distribution drivers, we examined schoolchildren Kwale, Kenya.We conducted a cross-sectional study 368 from six primary schools. Soil-transmitted helminths...
Idiopathic pulmonary fibrosis (IPF) is marked by the activation of fibroblasts, leading to excessive production and deposition extracellular matrix (ECM) within lung parenchyma. Despite pivotal role ECM overexpression in IPF, potential negative regulators fibroblasts have yet be identified. Semaphorin class 3B (SEMA3B), a secreted protein highly expressed tissues, has established roles axonal guidance tumor suppression. However, SEMA3B pathogenesis IPF remains unexplored. Here, we show downregulation
Asthma is a chronic inflammatory airway disease characterized by hyperresponsiveness (AHR), inflammation, and goblet cell hyperplasia. Multiple cytokines, including IFNγ, IL-4, IL-13 are associated with asthma; however, the mechanisms underlying effects of these cytokines remain unclear. Here, we report significant increase in expression IL-31RA, but not its cognate ligand IL-31, mouse models allergic asthma. In support this, upregulated IL-31RA IL-31 both human mice primary smooth muscle...
Idiopathic Pulmonary Fibrosis (IPF) is a severe fibrotic lung disease characterized by excessive collagen deposition and progressive decline in function. Th2 T cell-derived cytokines including IL-4 IL-13 have been shown to contribute inflammation remodeling multiple tissues. Interleukin-31 (IL-31) newly identified cytokine that predominantly produced CD4 cells, but its signaling receptor IL-31RA primarily expressed non-hematopoietic cells. However, the potential role of IL-31-IL31RA axis...
Lupus nephritis is one of the most serious complications systemic lupus erythematosus and manifests with considerable phenotypic histological heterogeneity. In particular, diffuse proliferative (DPLN) membranous (MLN) represent morphologic forms that are polar opposites. DPLN associated autoimmune responses dominated by Th1 immune response high levels interferon (IFN)-γ. contrast, a Th2 cytokine pathogenesis MLN. MRL/lpr mice develop human LN-like complex-associated provide suitable model...
Pulmonary macrophage transplantation (PMT) is a gene and cell approach in development as therapy for hereditary pulmonary alveolar proteinosis (hPAP), surfactant accumulation disorder caused by mutations
To eliminate schistosomiasis, appropriate diagnostic tests are required to monitor its prevalence and transmission, especially in the settings with low endemicity resulting from consecutive mass drug administration. Antibodies that react either crude soluble schistosome egg antigens or worm antigen preparations have been used infection low-prevalence regions. However, these detection methods cannot discriminate current past infections cross-reactive other parasites because both contain...
Abstract The host immune response to Schistosoma infection is characterized by two main phases, Th1 and Th2 consecutively, the later one being related excretion of mature eggs adult female worm. Interleukin-33 (IL-33), a inducing cytokine, has been reported be associated with schistosomiasis. Here we assessed role this epithelial cytokine on time course experimental S. mansoni in mouse. IL-33 knockout (KO) wild type (WT) 6-week-old BALB/c mice were infected 50 cercariae sacrificed at 0, 6, 8...
Asthma is a chronic inflammatory airway disease characterized by hyperresponsiveness (AHR), inflammation, and goblet cell hyperplasia. Both Th1 Th2 cytokines, including IFN-γ, IL-4, IL-13 have been shown to induce asthma; however, the underlying mechanisms remain unclear. We observed significant increase in expression of IL-31RA, but not its cognate ligand IL-31 during allergic asthma. In support this, IFN-γ IL-4 IL-13, upregulated IL-31RA smooth muscle cells (ASMC). Importantly, loss...
ABSTRACT While the role of CD8 + T cells in influenza clearance is established, their contribution to pathological lung injury increasingly appreciated. To explore if protective versus functions can be linked cell subpopulations, we dissected responses influenza-infected murine lungs. Our single-cell RNASeq (scRNAseq) analysis revealed significant diversity subpopulations during peak viral load vs. infection-resolved state. enrichment Cxcr3 hi effector (T eff ) subset was associated with a...
An exuberant host response contributes to influenza A virus (IAV) (or influenza)-mediated lung injury. However, despite significant information on the IAV, cellular framework and molecular interactions that dictate development of acute injury in IAV-infected lungs remain incompletely understood. We performed an unbiased single-cell RNA sequencing (scRNAseq) analysis examine heterogeneity regulation responses IAV model At level, infection promoted overwhelming recruitment monocytes exhibited...
Context and objective: Proprotein Convertase Subtilisin Kexin type 9 (PCSK9) plays an important role in lipid homeostasis. The present study aimed to determine whether PCSK9 is a potential cardiovascular risk (CVR) factor among apparently healthy people.
 Methods: A cross-sectional was conducted between August 2016 July 2020 the City of Kinshasa, Democratic Republic Congo. Volunteer regular blood donors from Catholic medical network (Bureau Diocésain des OEuvres Médicales...
Abstract Acute lung injury (ALI) caused by influenza A virus (IAV or influenza) manifests from dysregulated cellular interactions between hematopoietic and non-hematopoietic cells that develop into a pathologic host response. However, the lung’s diverse framework dictates response acute remains incompletely understood. We performed single-cell RNA-seq (scRNA-seq) analysis of total in mice severe to examine heterogeneity cell-specific regulation observed IAV infection resulted significant...