A5037292686- COVID-19 Clinical Research Studies
- Dialysis and Renal Disease Management
- Blood Pressure and Hypertension Studies
- SARS-CoV-2 and COVID-19 Research
- Lipoproteins and Cardiovascular Health
- Obstructive Sleep Apnea Research
- Sleep and related disorders
- Healthcare Systems and Practices
- Iron Metabolism and Disorders
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Neurological and metabolic disorders
- Long-Term Effects of COVID-19
- Chronic Kidney Disease and Diabetes
- Neuroscience of respiration and sleep
- Hemoglobinopathies and Related Disorders
- Liver Disease Diagnosis and Treatment
- COVID-19 diagnosis using AI
- Health, Medicine and Society
- Blood donation and transfusion practices
- Cardiovascular Function and Risk Factors
- Diabetes Management and Research
- Respiratory Support and Mechanisms
- Menopause: Health Impacts and Treatments
- COVID-19 and healthcare impacts
- SARS-CoV-2 detection and testing
University of Kinshasa
2015-2024
Kōchi University
2017
Ministry of Public Health
2016
Despite the growing incidence of acute kidney injury (AKI) worldwide, there is little data on burden and outcomes AKI in intensive care unit (ICU) low resource settings. The present study assessed its impact mortality ICU Kinshasa (Democratic Republic Congo). In a prospective cohort study, 476 consecutive critically ill patients (mean age 52 years, 57 % male) were screened for presence seven from January 1st to March 30th, 2015. Serum creatinine was measured by enzymatic method (Cobas C111...
Uncontrolled hypertension remains an important issue in daily clinical practice worldwide. Although the majority of patients are treated primary care, most data on blood pressure control originate from population-based studies or secondary healthcare.The aim this study was to evaluate frequency uncontrolled and associated risk factors among hypertensive followed at care facilities Kinshasa, capital city Democratic Republic Congo.A sample 298 seen healthcare facilities, 90 men 208 women, aged...
Objectives To study the prevalence and risk markers of diabetes mellitus intermediate hyperglycaemia (IH) in Kisantu, a semirural town Bas-Congo province, The Democratic Republic Congo. Design A cross-sectional population-based survey. Settings modified WHO STEPwise strategy was used. Capillary glycaemia measured for fasting plasma glucose 2-h-postload glucose. Both WHO/IDF (International Diabetes Federation) 2006 American Association (ADA) 2003 diagnostic criteria IH were Participants 1898...
Although the lungs remain main target of SARS-CoV-2, other organs, such as kidneys, can be affected, which has a negative impact on outcomes COVID-19 patients. previous studies kidney disease in reported mainly SARS-CoV-2-induced tubular and interstitial injury, there is growing evidence coming out Africa glomerular involvement, especially collapsing glomerulopathy seen particularly people African descent. We report case revealed by acute injury new onset full blown nephrotic syndrome black...
This study aimed to determine the prevalence and predictors of metabolic syndrome (MetS) among Congolese pre- postmenopausal women.In total, 200 women (100 premenopausal 100 postmenopausal) were interviewed underwent clinical biological investigations searching for lipid non-lipid cardiovascular risk factors. National Cholesterol Education Program-Adult Treatment Panel III (NCEP-ATPIII) criteria used define MetS. Multivariate logistic regression analysis was evaluate MetS.There significant...
Pulmonary embolism (PE) is common but difficult to diagnose.To describe the epidemiological, clinical and paraclinical characteristics of PE in Kinshasa hospitals.This was a retrospective study 158 cases with suspected PE.The prevalence 37% among suspicion disease. Male sex predominant (55%). The mean age 55 ± 15 years. main risk factors were obesity (53%), immobilisation (43%) surgery (14%). symptoms dyspnoea (98%), cough (59%), chest pain unilateral limb (36%). Tachypnoea (88%),...
Rheumatoid arthritis (RA) is associated with a 5 to 10 years reduction in life expectancy due premature atherosclerosis. This the consequence of traditional cardiovascular risk factors (TCRF) as well systemic inflammation. The aim present study was describe prevalence and subclinical atherosclerosis RA at University Hospital Kinshasa (UHK).Patients diagnosis based on 2010 ACR/EULAR criteria were included this cross-sectional from 1 June 2014 31 May 2015 UHK. disease activity measured using...
Chronic kidney disease (CKD) is a major worldwide health problem. However, its burden among adolescents and young adults unknown, especially in sub-Saharan Africa. The aim of this study was to investigate prevalence the school environment. concordance usual formulas used estimate renal function also assessed.In an epidemiological cross sectional study, random sample 524 pupils (263 boys, mean age 18.7 ± 1.4 years) from environment Kinshasa were studied. Recorded parameters interest...
The serum ferritin assay is recommended in Sickle Cell Anemia (SCA) patients receiving regular transfusions. According to several authors, elevated iron stores indicating chelation corresponds hyperferritinemia ≥500 ng/ml, and becomes detectable after twenty blood objectives of the study were determine prevalence identify associated risk factors a case series Steady state SCA Congolese children.Serum was assayed children followed 2 specialized hospitals Kinshasa. Elevated defined as level ≥...
Introduction Acute kidney injury (AKI) is a complication of severe coronavirus disease 2019 (COVID-19). Kidney damage associated with COVID-19 could take specific features due to environmental and socio-cultural factors. This study evaluates the incidence AKI, factors, mortality in patients Sub-Saharan African intensive care unit.
BACKGROUND QTc interval prolongation with an increased risk of torsade de pointes (Tsd) has been described in coronavirus disease 2019 (COVID-19) patients treated hydroxychloroquine (HCQ) and azithromycin (AZI) Western countries. In the DR Congo, few studies have evaluated safety this association or proposed new molecules. AIM To determine incidence Tsd COVID-19 HCQ-AZIs vs doubase C (new molecule). METHODS present randomized clinical trial, we included mild moderate either HCQ-AZI C....
Stroke is the third leading cause of cardiovascular mortality in dialysis patients. The objective this study was to assess extent stroke chronic hemodialysis Historical cohort patients enrolled two (HD) centers from January 1, 2010 December 31, 2011, including 191 (mean age 52 years, 68% men). Incidence curves and survival time analysis between first day HD end were described by Kaplan-Meier method. Independent predictors identified multiple logistic regression analysis. P < 0.05 defined...
Objective:The aim of this study was to evaluate the determinants chronic kidney disease (CKD) with special emphasis on sickle cell trait (SCT).Methods: Three hundred and fifty-nine patients (171 men 188 women), aged 18 years or older, reduced function (eGFR < 90 ml/min/1.73m 2 ) seen at secondary tertiary healthcare in Kinshasa were consecutively recruited cross-sectional study.Serum creatinine haemoglobin electrophoresis performed each patient.CKD defined as 60 .Logistic regression analysis...
In symptomatic patients, the diagnostic approach of COVID-19 should be holistic. We aimed to evaluate concordance between RT-PCR and serological tests (IgM/IgG), identify factors that best predict mortality (clinical stages or viral load).The study included 242 patients referred University hospital Kinshasa for suspected COVID-19, dyspnea ARDS June 1st, 2020 August 02, 2020. Both antibody-SARS-CoV2 IgM/IgG method were performed on day admission hospital. The clinical established according...
We aimed to assess the prevalence of prehypertension and its associated factors in a population Congolese pre postmenopausal women.We had consecutively recruited 200 women (100 premenopausal 100 postmenopausal) aged 40 - 60 years at department Gynecology Obstetrics, University Kinshasa Hospital, AKRAM Medical Center Kinshasa, DRC. An interview was carried out using questionnaire that comprised questions related lifestyle, menses characteristics, medical history diabetes, CVD, hypertension,...
Summary Background One year after the coronavirus disease 2019 (COVID-19) pandemic, focus of attention has shifted to emergence and spread severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) variants concern (VOCs). The aim study was assess frequency VOCs in patients followed for COVID-19 at Kinshasa university hospital (KUH) during 3rd 4th waves pandemic Kinshasa. Hospital mortality compared that first two waves. Method present included all whom diagnosis SARS-CoV-2 infection...
Objective: To determine the prevalence of circadian BP patterns and to assess factors associated with non-dipping pattern in untreated treated hypertensive patients, studied separately. Methods: Clinical data ABPM were obtained from 52 168 patients referred for Monkole Hospital Kinshasa. Twenty-four was performed using an oscillometric device. Non-dipping encompasses (nocturnal systolic dip less than 10% daytime BP) reverse dipping (mean night SBP higher day SBP). Results: 75% (63.5% 11.5%...
Cardiovascular (CV) disease is the leading cause of mortality in patients with end-stage kidney (ESKD). The aim present study was to determine whether Proprotein Convertase Subtilisin/Kexin type 9 (PCSK9) could be an independent predictor CV events and all-cause black African haemodialysis patients.We carried out a prospective cohort all consecutive hemodialysis (HD) between August 2016 July 2020, admitted six centers Kinshasa, Democratic Republic Congo. Independent determinants plasma...
Cardiovascular disease (CVD) risk in type 2 diabetes mellitus (T2DM) increases with the development of albuminuria and is related part to dyslipidemia. The present analysis assessed lipid profile patterns dyslipidemia T2DM patients according status. This was a post hoc data from 181 seen at tertiary health-care hospital enrolled cross-sectional study Abnormal defined as microalbuminuria [albumin creatinine ratio (ACR) 30-299.9 mg/g] or macro-albuminuria (ACR ≥300 mg/g). Atherogenic...
Objective: To assess the LV mass, geometry and systolic function in hypertensive patients with reduced kidney function. Methods: According to ASE guidelines, we estimated ventricular 155 consecutive [51% women, mean age 51 ± 12 years, median duration of hypertension 7 years] (eGFR 2 or dipstick proteinuria ≥ 1+). LVH was defined as LVMI >125 g/m2 men, >110 non obese women >51 g/m2.7 for men women. Where appropriate, used Student t, Mann Whitney, one way ANOVA Chi square tests. A P value 0.05...
Although cardiovascular diseases in particular Pulmonary Arterial Hypertension (PAH) is associated with, high morbid-mortality chronic hemodialysis, but its magnitude remains paradoxically unknown sub-Saharan Africa. The aim of this study was to evaluate the prevalence PAH and factors hemodialysis Sub-Saharan African population.In a cross-sectional study, patients treated with HD for at least 6 months 4 centers were examined. defined as estimated systolic pulmonary arterial pressure (sPAP) ≥...
We included all patients with respiratory symptoms (dyspnea, fever, and cough) and/or failure admitted to the SOS Médecins de nuit SARL hospital, DR Congo, during 2nd 3rd waves of COVID-19 pandemic. The diagnosis was established based on RT-PCR anti-SARS-CoV-2 tests (G1 (RT-PCR positive) vs. G2 negative)), had a chest CT day admission. retrieved digital files patients, precisely clinical, biological, parameters admission as well vital outcome (survival or death). Chest were read by very...
Objective: We assessed the frequency of erectile dysfunction and associated risk factors among diabetic patients attending Kinshasa hospitals. Methods: enrolled 205 male (mean age: 53 ± 11 years) from three public hospitals at to assess defined by a score 6 20 on International Index Erectile Function (IIEF-5). Logistic regression model was applied identify determinants dysfunction. A p-value ≤ 0.05 considered significant. Results: observed in 59% (95% CI: 52.2 - 66%) patients; it mild,...