Tea catechins, (-)-epicatechin (EC), (-)-epigallocatechin (EGC), gallate (ECG), and (EGCG), have been shown to be epimerized (-)-catechin (C), (-)-gallocatechin (GC), (CG), (GCG), respectively, during heat treatment. In this study, we examined the effect of tea catechins rich in ECG EGCG heat-treated CG GCG on postprandial hypertriacylglycerolemia rats. Both suppressed hypertriacylglycerolemia. Lymphatic recovery (14)C-trioleoylglycerol rats cannulated thoracic duct was delayed by...

The role of long noncoding RNAs (lncRNAs) in the epithelial-mesenchymal transition (EMT) pancreatic ductal adenocarcinoma (PDAC) is unclear. Some lncRNAs can be transferred by extracellular vesicles (EVs) and have potential as biomarkers. Here, we identify an lncRNA that could serve a biomarker for PDAC show functional roles lncRNA. Expression profiling revealed highly upregulated liver cancer (HULC) was expressed, induced, transforming growth factor-β cells their EVs. Knockdown HULC...

Macrophages are known to be phagocytes in the olfactory epithelium of adult rats. The participation other cell types phagocytosis association with death process was examined after unilateral bulbectomy neonatal mice. terminal deoxynucleotidyl transferase (TdT)-mediated biotinylated dUTP nick end-labeling (TUNEL) method revealed that consists acute and chronic periods. number apoptotic profiles on operated side peaked at 1 day, percentage labeled 13.6%. dying cells rapidly decreased 3 days...

The metabolism of theanine, one the major amino acid components in tea (Camellia sinensis), was studied rats. High-performance liquid chromatography (HPLC) with fluorometric detection used to evaluate nature theanine's metabolites plasma, urine, and tissues. In urine samples collected after administration 100, 200, 400 mg each intact L-glutamic acid, ethylamine, these compounds were detected a dose-dependent manner. When 200 theanine orally administered rats, plasma concentrations ethylamine...

Epidemiological surveys suggest that a higher intake of tea may be associated with lower risk CHD. There is accumulating evidence postprandial lipaemia makes substantial contribution to the incidence Our aim was, therefore, evaluate effect catechins (major ingredients in green tea) on lipid responses human subjects after consumption test meals. In randomized triple-crossover design, nine male mild or borderline hypertriacylglycerolaemia consumed 10 (control), 224 (moderate dose) and 674 mg...

Tea catechins, rich in (−)-epigallocatechin gallate and (−)-epicatechin gallate, or heat-treated tea catechins which about 50% of the was epimerized to (−)-gallocatechin (−)-catechin were fed rats at 1% level for 23 d. Visceral fat deposition concentration hepatic triacylglycerol significantly lower catechin groups than control group. The activities fatty acid synthase malic enzyme liver cytosol two In contrast, carnitine palmitoyltransferase acyl-CoA oxidase homogenate not different among...

We investigated the effect of consumption a catechin-containing drink on body fat level and its safety in healthy adults. The beverage (250 ml/bottle) contained 215.3 mg tea catechins mostly possessing galloyl moiety, which included (-)-epigallocatechin gallate 74.6 mg, (-)-epicatechin 34.1 (-)-gallocatechin 77.8 (-)-catechin 24.5 mg. conducted double-blind study with three parallel groups. Healthy subjects (98 men 97 women) aged from 20 to 65 years old 22.5 < mass index (BMI) ≤ 30 kg/m2...

Di-(2-ethylhexyl)phthalate (DEHP) is a plasticizer and ubiquitous environmental contaminant that may have adverse effects on human reproductive health. We examined the long-term exposure of DEHP female rats observed strong effect estrous cyclicity produced continuous diestrous stage. found serum estradiol, follicle-stimulating hormone (FSH), pituitary FSH luteinizing levels were significantly reduced in treated rats. To examine endocrine disrupting effects, we performed proteome-based...

The rodent olfactory epithelium (OE) is a good model system for studying the principles of stem and progenitor cell biology, because its capacity continuous neurogenesis throughout life relatively well-characterized neuronal lineage. development mouse OE divided into two stages, early established neurogenesis. In neurogenesis, which starts at embryonic day (E) 12.5, sustentacular cells receptor neurons (ORNs) are produced from apical basal progenitors, respectively. We previously reported...

Administration of black-tea polyphenols (BTP) at 100 and 200 mg/kg body weight in rats suppressed postprandial hypertriacylglycerolemia a dose-dependent manner. BTP also lymphatic recovery (14)C-trioleoylglycerol that were cannulated the thoracic duct. dose-dependently inhibited activity pancreatic lipase vitro with an IC50 0.254 mg/mL. When purified theaflavins, which are components BTP, used, theaflavins galloyl moieties, but not those without moiety, lipase. Theaflavin-3,3'-digallate...

Abstract Among the variety of isolable compounds with multiple bonds involving silicon, examples that contain silicon–boron double (borasilenes) still remain relatively rare. Herein, we report synthesis potassium salt a chloride adduct borasilene 1 ([ 2 ] − ), which was obtained as an orange crystalline solid. Single‐crystal X‐ray diffraction analysis and reactivity studies on [ confirmed double‐bond character Si=B bond well reduced Lewis acidity, is due to coordination Cl boron center. A...

Background Fibrinolysis is spatiotemporally well-regulated and greatly influenced by activated platelets coagulation activity. Our previous real-time imaging analyses revealed that clotting commences on platelet surfaces, resulting in uneven-density fibrin structures, fibrinolysis initiates dense regions extends to the periphery. Despite widespread clinical use of direct oral anticoagulants (DOACs), their impact thrombin-dependent activation thrombin-activatable inhibitor (TAFI) remains...

Background To evaluate residual fibrinolysis resistance activity (FRA) in plasma, a detergent-modified plasma clot lysis assay time (dPCLT) was established which α2-antiplasmin (A2AP) and plasminogen activator inhibitor type 1 (PAI-1) are inactivated without impacting protease activity. We applied this novel to severely injured trauma patients’ plasma. Material Methods Tissue-type (tPA)-induced assays were conducted after detergents- or vehicle- (sPCLT) treatment, 50% measured (“transition...

Banaba in the Tagalog name, Lagerstroemia speciosa L., has been used as a folk medicine for long time among diabetics Philippines. Extracts from banaba leaves have reported to reduce diabetic symptoms genetically mice (Type II, KK-Ay). In present study, female of same strain showing remarkable body weight gain were examine antiobesity effect dietary extract. Five-week-old KK-Ay fed control diet or test containing 5% hot-water extract instead cellulose 12 wk. Neither group showed any changes...

We have previously reported that the administration of a large amount di(n-butyl)phthalate (DBP) increased conversion ratio tryptophan to niacin in rats. In present experiment, effect di(2-ethylhexyl)phthalate (DEHP) on and how altering depended concentration DEHP were investigated elucidate toxic mechanism phthalic acid esters (PhE). Rats fed with diet containing 0%, 0.01%, 0.05%, 0.1%, 0.5%, 1.0%, or 3.0% for 21 days. To assess niacin, urine samples collected at last day experiment...

The distribution of the neural cell adhesion molecule (N-CAM) in taste buds adult and developing mice was studied by use an immunocytochemical technique. In mice, nerve fibers some elongated bud cells reacted with anti-N-CAM antibody. Immunoelectron microscopic observation showed that only type-III (gustatory) cells, which have afferent synaptic contacts nerves, were N-CAM positive buds. At day 0 after birth, first appeared circumvallate papillae, corresponded to having synapses, found. This...

Although the stimulatory effect of glucagon-like peptide 1 (GLP-1), a cAMP-generating agonist, on Ca2+ signal and insulin secretion is well established, underlying mechanisms remain to be fully elucidated. We recently discovered that influx alone can activate conventional protein kinase C (PKC) as novel PKC in insulin-secreting (INS-1) cells. Building this earlier finding, here we examined whether GLP-1-evoked signaling PKCα PKCϵ at substimulatory concentration glucose (3 mm) INS-1 first...

Bis(ferrocenyl)germylene Fc*2 Ge: [2; Fc*=2,5-bis(3,5-di-tert-butylphenyl)-1-ferrocenyl] was isolated in the form of red crystals from reaction sterically demanding ferrocenyl lithium dimer (Fc*Li)2 and GeI2 . 2 exhibits extraordinary thermal stability hydrocarbon solution solid state, as well stable redox behavior. Moreover, it undergoes a ligand-redistribution with GeCl2 ⋅(dioxane) to afford corresponding chlorogermylene, which upon coordination PBu3