A5101990878- Cardiovascular Function and Risk Factors
- Cardiomyopathy and Myosin Studies
- Cardiovascular Effects of Exercise
- Cardiac Structural Anomalies and Repair
- Congenital Heart Disease Studies
- Gastrointestinal motility and disorders
- Cardiovascular and Diving-Related Complications
- Parkinson's Disease Mechanisms and Treatments
- Cardiac Health and Mental Health
- Neuropeptides and Animal Physiology
- Cardiac, Anesthesia and Surgical Outcomes
- Blood Pressure and Hypertension Studies
- Signaling Pathways in Disease
- Nuclear Receptors and Signaling
- Dysphagia Assessment and Management
- Transportation Planning and Optimization
- Stress Responses and Cortisol
- Eicosanoids and Hypertension Pharmacology
- Eosinophilic Disorders and Syndromes
- Hearing, Cochlea, Tinnitus, Genetics
- Cardiac pacing and defibrillation studies
- Biochemical Analysis and Sensing Techniques
- Pulmonary Hypertension Research and Treatments
- Metabolomics and Mass Spectrometry Studies
- Cardiac Arrhythmias and Treatments
Beijing Anzhen Hospital
2017-2024
Capital Medical University
2010-2024
Beijing Children’s Hospital
2024
Beijing Chaoyang Emergency Medical Center
2021
Accurate prediction of death is an unmet need in patients with acute decompensated heart failure (HF). Arachidonic acid (AA) metabolites play important role the multiple pathophysiological processes. We aimed to develop AA score accurately predict mortality HF and explore causal relationship between predictors HF.The serum was measured (discovery cohort n=419; validation n=386) by mass spectroscopy. assessed prognostic importance for 1-year using Cox regression machine learning approaches. A...
The aim of this study was to evaluate the effect 3-dimensional (3D) printing in treatment hypertrophic obstructive cardiomyopathy (HOCM) and its roles doctor-patient communication.3D-printed models were constructed preoperatively postoperatively seven HOCM patients received surgical treatment. Based on multi-slice computed tomography (CT) images, regions disorder segmented using Mimics 19.0 software (Materialise, Leuven, Belgium). After generating an STL-file (StereoLithography file) with...
Non-motorised travel and public transportation are recognised as low-carbon modes, in contrast to car travel, which is considered a non-low-carbon option. Based on this, the paper proposes stratified assessment method for urban potential. The proportion of motorised population that could potentially shift non-motorised within entire defined Tier 1 Meanwhile, 2 This holistically presents potential improvement traffic carbon emission control. considers distance primary negative factor...
Emodin (1,3,8-trihydroxy-6-methylanthraquinone) is an active component of many herb-based laxatives. However, its mechanism action unclear. The aim the present study was to investigate role mast cells and enteric neurons in emodin-induced ion secretion rat colon.
Background The functions of the distal colon are regulated by local and extrinsic neural pathways. In previous studies, we have found that dopamine (DA) norepinephrine (NE) could evoke colonic ion transport activating β-adrenoceptors. present study aims to investigate segmental differences in expression activation β-adrenoceptors physiological pathophysiological conditions. Methods Real-time PCR, immunofluorescence, Western blotting were used detect rat human colon. Short-circuit current...
Abstract In response to pathological stimuli, the heart develops ventricular hypertrophy that progressively decompensates and leads failure. miRNAs are increasingly recognized as pathogenic factors, clinically relevant biomarkers, potential therapeutic targets. We identified mir15a/mir16‐1 cluster was negatively correlated with hypertrophic severity in patients cardiomyopathy. The expression enriched cardiomyocytes (CMs), decreased human hearts, mouse hearts after transverse aortic...
Background Entacapone is a promising drug used widely for the treatment of Parkinson's disease (PD) as catechol-O-methyl transferase (COMT) inhibitor. However, entacapone has gastrointestinal side effects. The aim this study was to investigate effects on epithelial ion transport in rat distal colon, and explore underlying mechanism. Methods performed freshly isolated colonic mucosa-only, submucosa-only mucosa–submucosa preparations rat. short circuit current (ISC) measured determine...
The study was conducted to evaluate the surgical results in patients with hypertrophic obstructive cardiomyopathy (HOCM) who underwent either classic Morrow septal myectomy or modified procedure. has gained interest as a new treatment for drug-refractory symptoms of HOCM; however, its benefits comparison procedure are unknown. In all, 236 symptomatic HOCM from January 2006 2015. Among them, 86 were treated by and 150 via Septal thickness, maximal left ventricular outflow tract (LVOT)...
Background: Percutaneous transluminal septal myocardial ablation (PTSMA) and modified Morrow myectomy (MMSM) are two invasive strategies used to relieve obstruction in patients with hypertrophic cardiomyopathy (HCM). This study aimed determine the clinical outcome of these strategies. Methods: From January 2011 2015, 226 HCM were treated, 68 by PTSMA 158 MMSM. Both ultrasonic cardiograms heart functional class recorded before, after operations follow-up. Categorical variables compared using...
Advanced cardiovascular surgery in structural heart disease require accurate pre-operative evaluation. Most of non-invasive imaging technologies remain limited two-dimensional and show insufficiency visualization for procedural planning. The aim this study was to discuss the value patient-specific 3-dimensional (3D) printing treatment hypertrophic cardiomyopathy (HCM).Patient-specific 3D-printed models were constructed preoperatively 12 consecutive HOCM patients which come Beijing Anzhen...
Abstract Background Type 2 diabetes mellitus is common in cardiovascular disease. It associated with adverse clinical outcomes for patients who had undergone coronary artery bypass and valve operations. The aim of this study was to evaluate the impact type on midterm hypertrophic cardiomyopathy underwent septal myectomy. Methods We retrospectively analyzed data 67 myectomy from two medical centers China 2011 2018. A propensity score–matched cohort 134 without also analyzed. Results During a...
Abstract Background Obstructive sleep apnea (OSA) is a common disease associated with worse structural and functional impairment of the heart in patients hypertrophic obstructive cardiomyopathy (HOCM). Hypothesis The presence severity OSA can decrease right ventricular ejection fraction (RVEF) HOCM. Methods In total, 151 consecutive confirmed diagnosis HOCM at Fuwai Hospital between September 2017 2018 were included. Polysomnography cardiac magnetic resonance imaging performed all patients....
To investigate the therapeutic effectiveness of endoscopic retrograde cholangiopancreatography (ERCP) and stent implantation in treatment pancreaticobiliary injuries children.
Background: The incidence of obstructive sleep apnea (OSA) is significantly higher in patients who undergo coronary artery bypass grafting (CABG). OSA correlated with a postoperative complications undergoing CABG. However, whether associated decrease renal function and dialysis after CABG remains unclear.
Hypertrophic cardiomyopathy (HCM) with extreme interventricular septal thickness (IVST) is associated a higher incidence of adverse cardiovascular events. However, the results these patients who underwent myectomy are unclear.We studied 47 HCM IVST ≥30 mm between 2011 and 2018 in Anzhen Hospital. After 2:1 propensity score matching, study cohort included 141 94 <30 mm.Patients had longer clinical course disease, high syncope, palpitation, moderate or severe mitral regurgitation. mean...
Obstructive sleep apnea (OSA) is associated with a higher prevalence of postoperative atrial fibrillation in patients who underwent cardiac surgery. However, whether OSA risk factor for after septal myectomy remains unclear. We hypothesized that was myectomy.A total 99 hypertrophic obstructive cardiomyopathy were included our manuscript. Polysomnography performed all patients, and the heart rhythm continuously monitored during perioperative period.In present study, 25 (25.3%) developed...
Patients with patent ductus arteriosus (PDA) are usually detected and treated during childhood, however, some not until adulthood. In addition, heart failure, severe pulmonary hypertension, calcification of the may also exist. Transcatheter occlusion has become a widely used technique for closure small to moderate sized PDAs since Cambier first reported use Gianturco coils transcatheter PDA in 1992 [Cambier 1992]. case studies here, one-stage hybrid procedure combined other cardiac anomalies...