A5101489132- Crystallization and Solubility Studies
- Oxidative Organic Chemistry Reactions
- X-ray Diffraction in Crystallography
- Synthetic Organic Chemistry Methods
- Natural product bioactivities and synthesis
- Marine Sponges and Natural Products
- Asymmetric Synthesis and Catalysis
- Chemical synthesis and alkaloids
- Phytochemical compounds biological activities
- Traditional and Medicinal Uses of Annonaceae
- Pharmacological Effects of Natural Compounds
- Metabolomics and Mass Spectrometry Studies
- Ginseng Biological Effects and Applications
- Organic Chemistry Cycloaddition Reactions
- Synthesis of Organic Compounds
- Gut microbiota and health
- Advanced Synthetic Organic Chemistry
- Oral Health Pathology and Treatment
- Traditional Chinese Medicine Analysis
- Plant-based Medicinal Research
- Carbohydrate Chemistry and Synthesis
- Tea Polyphenols and Effects
- Chromatography in Natural Products
- Bioactive natural compounds
- Lipid metabolism and disorders
Guangdong Academy of Sciences
2021-2025
Institute of Zoology
2021-2025
Northeastern University
2022
Sun Yat-sen University
2017-2020
Hong Kong University of Science and Technology
2012-2017
University of Hong Kong
2012-2017
Fujian Agriculture and Forestry University
2016
Zhejiang University
2013
Sir Run Run Shaw Hospital
2013
Inner Mongolia University of Technology
2010
Aging is an inevitable biological process characterized by the loss of functional capacity and associated with changes in all phases pharmacokinetic processes. Naringin, a dietary flavanone glycoside, has been proved to be beneficial for treatment multiple age-associated chronic diseases. To date, processes naringin aged individuals are still unknown. Thus, rapid resolution liquid chromatography tandem triple quadrupole mass spectrometry (RRLC-QQQ-MS/MS) method was established determination...
Exocarpium Citri grandis (ECG) is an important Traditional Chinese Medicine (TCM) for the treatment of cough and phlegm, flavonoids contained were considered main effective components. To date, systematic chemical profiling these derived in vivo metabolites human have not been well investigated. ECG was extracted using boiling water then provided to volunteers oral administration. Following ingestion, urine samples collected from over 48 h. The extract analyzed ultra-fast liquid...
The polysaccharides from Stemona tuberosa Lour, a kind of plant used in Chinese herbal medicine, have various pharmacological activities, such as anti-inflammatory and antioxidant properties. However, the effects extraction methods activity different parts are still unknown. Therefore, this study aimed to evaluate on yields, chemical compositions, bioactivity extracted Lour. Six were leaves, roots, stems Lour through use hot water (i.e., SPS-L1, SPS-R1, SPS-S1) an ultrasound-assisted method...
Nitrile imines are highly reactive and versatile dipoles conventionally generated in situ from unstable hydrazonyl halides under basic conditions. Herein, we report the first green user-friendly protocol for generation of nitrile Oxone–KBr oxidation hydrazones base-promoted dehydrobromination. The were demonstrated 1,3-dipolar cycloaddition with various dipolarophiles, including alkene alkyne groups. With its nature, ease operation, air moisture tolerance, expect our method will find wide...
Acute lung injury (ALI) is an inflammation-mediated respiratory disease with a high mortality rate. Medications anti-inflammatory small molecules have been demonstrated in phase I and II clinical trials to considerably reduce the ALI mortality. In this study, two series of lansiumamide analogues were designed, synthesized, evaluated for activity treatment. We found that compound 8n exhibited best through inhibiting LPS-induced expression proinflammatory cytokines interleukin-6 (IL-6)...
The first total syntheses of (−)-penicipyrone and (−)-tenuipyrone were accomplished enantioselectively in 12 steps with an 11% yield 6 a 28% from the known 4-((tert-butyldimethylsilyl)oxy)-cyclopent-2-enone, respectively, by developing biomimetic bimolecular cascade cyclization featuring intermolecular Michael addition/cyclo-(spiro-)ketalization sequence. relative, absolute stereochemistry carbon connectivity penicipyrone was further confirmed X-ray crystallographic analysis comparison...
Although Aurantii Fructus (AF) and Immaturus (AFI) are both the fruits of same rutaceae plant at different stages growth, they exert similar yet distinct clinical effects. The chemical composition is crucial for quality control as well therapeutic application. To address this concern, it significant to evaluate similarities differences constituents in AF AFI. extract AFI were comprehensively analyzed by ultra fast liquid chromatography-photodiode array detector-triple-time flight-tandem mass...
Abstract The novel tricyclic spiroketal alotane‐type sesterterpenoids showed strikingly different biological activities and potency with subtle structural alterations. Asymmetric total syntheses of the (−)‐alotaketals A–D (−)‐phorbaketal A were accomplished [29–31 steps from (−)‐malic acid] in a collective way for first time. key features strategy included 1) new cascade cyclization vinyl epoxy δ‐keto‐alcohols to forge common intermediate, 2) late‐stage allylic C−H oxidation, 3) olefin...
Naoxintong capsule (NXT), a Chinese medicine, has performed excellent effects on the prevention and treatment against cardiovascular diseases. NXT is fine powder mixture without any herb extraction, there must be lots of ingredients hard to absorbed. However, little known about correlation between NXT's cardioprotective gut microbiota. Herein, we report effect development diseases clarify In current study, minipigs were selected fed with high-fat diet daily for successive 8 months. During...
Abstract Naoxintong Capsule (NXT) is a Traditional Chinese Medicine formulation which has been widely applied in treating cardiovascular and cerebrovascular diseases. Previous studies also reported the potential effects of NXT against diabetes certain complications, yet its mechanisms remain largely obscured. Herein, this study, we investigated anti-diabetic as well mechanisms. Type 2 (T2D) was induced rats by 10-week high-fat diet companion with low-dose streptozotocin injection....
A new cascade approach has been developed for the one-pot four-step divergent synthesis of polysubstituted benzofurans and 2H-chromenes, featuring a novel aromatic Claisen rearrangement/Meinwald rearrangement/dehydrative or oxidative cyclization. This method was demonstrated with 39 examples tolerating different substitutions at an epoxide, allylic ether, ring, we showcased its utility first total natural product liparacid in seven steps.
The oxone–halide green oxidation system is extended to the of primary amides and aromatic aldehydes (with sodium azide) generate N -haloamide acyl azides, respectively, for subsequent Hofmann Curtius rearrangements.
Biomimetic total syntheses of potent antiviral spirooliganones A and B were achieved with 3% 2% yield, respectively, in 12 steps from commercially available materials. The synthetic strategy was inspired primarily by the biogenetic hypothesis enabled two independent cascade events: (i) an unprecedented reaction involving aromatic Claisen rearrangement/o-quinone methide formation/hetero-Diels–Alder cycloaddition to construct tetracyclic framework (ii) phenol oxidative...
Abstract Ansellane‐type sesterterpenoids including, ansellones A‐G and (+)‐phorbadione are structurally novel marine secondary metabolites which exhibit anticancer anti‐HIV activity. The first, asymmetric total syntheses of three representative members, (−)‐ansellones A B (+)‐phorbadione, were accomplished in 16–23 steps from (+)‐sclareolide. route features the first regioselective cyclization vinyl epoxides with internal alcohol nucleophiles a 1,4‐addition manner (S N 2′). Additionally,...
Widespread in citrus fruits, naringin, a natural 2,3-dihydroflavonoid, is of particular interest to scientists and has broad range beneficial bioactivities health. Orally administered naringin remains the gut tract for relatively long time because its low bioavailability. Under metabolism mediated by human microbiota, could be an active precursor derived metabolites play important physiological roles. However, are hard accurately quantify due severe endogenic interference. In this study,...
A new synthetic strategy was developed for a concise total synthesis of aculeatin as single spiroisomer in both racemic and enantioselective fashions 8-10 steps with ∼10% overall yield from the known alkyne 11, featuring phenol oxidative dearomatization, double intramolecular oxa-Michael addition secondary/tertiary alcohols, chemo- stereoselective reduction ketone. The greatly expedites access to potent antiprotozoal A, 6-epi-aculeatin D, their analogues.