A5065821595- Cancer-related molecular mechanisms research
- Extracellular vesicles in disease
- Monoclonal and Polyclonal Antibodies Research
- RNA modifications and cancer
- Biosimilars and Bioanalytical Methods
- SARS-CoV-2 and COVID-19 Research
- Cancer, Hypoxia, and Metabolism
- Cancer Immunotherapy and Biomarkers
- Circular RNAs in diseases
- Phytochemistry and Biological Activities
- Bioactive Natural Diterpenoids Research
- Immunotherapy and Immune Responses
- Bladder and Urothelial Cancer Treatments
- Statistical Methods in Clinical Trials
- RNA and protein synthesis mechanisms
- T-cell and B-cell Immunology
- Cell Adhesion Molecules Research
- RNA Interference and Gene Delivery
- PARP inhibition in cancer therapy
- Esophageal Cancer Research and Treatment
- Neuroblastoma Research and Treatments
- MicroRNA in disease regulation
- RNA Research and Splicing
- Liver physiology and pathology
- Ginkgo biloba and Cashew Applications
Shanghai Jiao Tong University
2009-2025
Tongji Hospital
2018-2025
Huazhong University of Science and Technology
2025
Fudan University
2018-2024
Stomatological Hospital of Chongqing Medical University
2006-2024
Chongqing Medical University
2006-2024
Center for Drug Evaluation and Research
2013-2024
Tongji University
2018-2023
Norwegian University of Science and Technology
2019-2022
Shanghai Public Health Clinical Center
2016-2022
Abstract Background Colorectal cancer (CRC) is the leading cause of cancer-related death worldwide. Exosome shave emerged as crucial regulators intercellular communication and that abundant Circular RNAs (circRNAs) are enriched within exosomes. CircRNAs novel members noncoding regulating proliferation progression. However, function regulatory mechanism cancer-derived exosomal circRNAs in CRC remains unclear. Methods cells-derived exosomes were characterized using transmission electron...
Abstract Background Long non-coding RNA (lncRNA) HOXA transcript at the distal tip (HOTTIP), has been demonstrated to be a vital biomarker when evaluating prognosis of multiple cancers. Nevertheless, potential function HOTTIP in ovarian cancer (OC), prevalent among women worldwide, remains elusive. Hence, current study aimed elucidate functional relevance development OC. Methods Positive expression PD-L1 and IL-6 was determined using immunohistochemical staining collected OC normal tissues....
The main objective of this paper is to propose a quantitative model describe the absorption process for monoclonal antibody (mAb) following subcutaneous (SC) or intramuscular (IM) administration. A hybrid was established by coupling physiologically based with conventional pharmacokinetic-pharmacodynamic (PK-PD) PK associated intravenous infusion. Key physiological parameters evaluated include volume distribution before systemic absorption, mAb drug clearance during lymphatic transport,...
Exosomes play important roles in proliferation and microenvironment modulation of many types cancers, including colorectal cancer (CRC).However, the inhibitory effect CRC cells-derived exosomes angiogenesis has not been fully discussed.In this study, microRNA-183-5p (miR-183-5p) abundant secreted from cells were investigated.Initially, microarray analysis was employed to determine differentially expressed miRNAs.Exosomes isolated co-cultured with HMEC-1 explore role angiogenesis.Further,...
It has been demonstrated that through the formation of embryoid bodies (EBs) germ cells can be derived from embryonic stem (ES) cells. Here, we describe a transgene expression approach to derive directly ES in vitro without EB formation. Through ectopic Deleted Azoospermia-Like (Dazl), cell-specific RNA-binding protein, both motile tailed-sperm and oocytes were induced mouse (mES) culture. Furthermore, transient overexpression Dazl led suppression Nanog but cell nuclear antigen mES knockdown...
Long noncoding RNAs (lncRNAs) have been reported to be involved in the occurrence and tumorigenesis of numerous malignant cancers. Microarray expression profiles were used screen colorectal cancer (CRC)-related differentially expressed genes lncRNAs, which revealed that insulin receptor substrate 1 (IRS1) lncRNA plasmacytoma variant translocation (PVT1) highly CRC. This study aimed investigate regulatory role PVT1 Subcellular localization detected by fluorescence situ hybridization...
Abstract Antibody-dependent enhancement (ADE) has been reported in several virus infections including dengue fever virus, severe acute respiratory syndrome (SARS) and Middle East (MERS) coronavirus infection. To study whether ADE is involved COVID-19 infections, vitro pseudotyped SARS-CoV-2 entry into Raji cells, K562 primary B cells mediated by plasma from recovered patients were employed as models. The of was more commonly detected severely-affected elderly with high titers spike...
We aimed to establish a Medical-Insurance-System-based Cancer Surveillance System (MIS-CASS) in China and evaluate the completeness timeliness of this system through reporting cancer incidence rates using claims data two regions northern southern China.We extracted from medical insurance systems Hua County Henan Province, Shantou City Guangdong Province Jan 1, 2012 Jun 30, 2019. These have been considered be high risk for oesophageal cancer. developed rigorous procedure MIS-CASS, which...
Purpose. Bladder cancer is one of the most common urological malignancies worldwide, and approximately 90% bladder cases are histologically typed as urothelial carcinoma (BLCA). Exosomes 30 to 200 nm extracellular vesicles that transport microRNAs, long noncoding RNAs (lncRNAs), mRNAs, circular RNAs, proteins across tissues through circulation. Urinary exosomes may contain genetic information from tumor cells. Herein, we explored clinical significance urinary exosomal lncRNA telomerase RNA...
Abstract The highly mutated and transmissible Omicron (BA.1) its more contagious lineage BA.2 have provoked serious concerns over their decreased sensitivity to the current COVID-19 vaccines evasion from most anti-SARS-CoV-2 neutralizing antibodies (NAbs). In this study, we explored possibility of combating by constructing bispecific based on non-Omicron NAbs. We engineered 10 IgG-like with NAbs named GW01, 16L9, 4L12, REGN10987 fusing single-chain variable fragments (scFvs) two through a...
Rationale: Antimicrobial peptides, such as cathelicidin LL-37/hCAP-18, are important effectors of the innate immune system with direct antibacterial activity.In addition, LL-37 is involved in regulation tumor cell growth.However, molecular mechanisms underlying functions promoting lung cancer not fully understood.Methods: The expression tissues and sera patients non-small was determined through immunohistological, immunofluorescence analysis, enzyme-linked immunosorbent assay.The animal...
To investigate the value of weight growth velocity, calculated using Patel exponential model and Z-score change method, in predicting neurological physical development outcomes preterm infants with a gestational age <30 weeks long term. A retrospective study was conducted involving who were hospitalized treated Department Neonatology at Tongji Hospital, Huazhong University Science Technology, from January 2017 to June 2022, followed up outpatient service more than 18 months age. The divided...
Multiple studies demonstrate the existence of attenuated neutralizing activity to Omicron variants in original SARS-CoV-2 strain vaccinated population undergoing breakthrough infection, which reflects a phenomenon immune imprinting humoral immunity. Herein, through designing spike protein peptide pools from four subvariants and wild type (WT) counterpart, we intended determine antiviral T cell immunoreactivity Omicron-infected COVID-19 patients with or without previous vaccination. We have...
Human DCTPP1 (dCTP pyrophosphatase 1), also known as XTP3-transactivated protein A, belongs to MazG-like nucleoside triphosphate (NTP-PPase) superfamily. Being a newly identified pyrophosphatase, its relevance tumorigenesis and the mechanisms are not well investigated. In present study, we have confirmed our previous study that was significantly hyperexpressed in breast cancer further demonstrated strong association with tumor progression poor prognosis cancer. Knockdown of cell line MCF-7...
Early diagnosis and treatment of colorectal cancer (CRC) significantly improves the survival rate quality life. Here we screened for differences in glycoproteins associated with tumor-derived exosomes validated their clinical value to serve as liquid biopsy biomarkers diagnosed early CRC. Exosomes were extracted from paracancerous tissues, plasma. LC-MS/MS proteomic glycoproteomics analyses performed using an LTQ-Orbitrap Elite mass spectrometer. The tissues tissue determined, levels plasma...
Abstract The Omicron subvariants BQ.1.1, XBB.1.5, and XBB.1.16 of SARS-CoV-2 are known for their adeptness at evading immune responses. Here, we isolate a neutralizing antibody, 7F3, with the capacity to neutralize all tested variants, including XBB.1.16. 7F3 targets receptor-binding motif (RBM) region exhibits broad binding panel 37 RBD mutant proteins. We develop IgG-like bispecific antibody G7-Fc using cross-neutralizing GW01. demonstrates robust activity against 28 variants...
Abstract Six tigliane-type diterpenoids (1–6) were isolated from the roots of Euphorbia fischeriana. Their structures elucidated by various spectral analyses. Among them, compounds 1 and 3 new, 2, 4, 5 naturally obtained for first time. All tested against two human cancer cell lines, MDA-MB-231 HepG2, one immortalized line, only compound 6 showed cytotoxicity cells with an IC50 value 6.694 μM. Keywords: Euphorbiaceae fischeriana tigliane diterpenoidscytotoxic Acknowledgement Financial...
// Li-liang Xia 1, 4, * , Ya-bin Tang 2, Fei-fei Song 2 Ling Xu Ping Ji Shu-jun Wang Ji-min Zhu 3 Yong Zhang Guo-ping Zhao 5 Ying Tao-tao Liu 1 State Key Laboratory of Genetic Engineering, Department Microbiology, School Life Sciences and Institute Biomedical Sciences, Fudan University, Shanghai, China Shanghai Immunology, Immunology Pharmacology Chemical Biology, Jiaotong University Medicine, Gastroenterology, Zhongshan Hospital, 4 Shanghai-MOST Health Disease Genomics, Chinese National...